Neural connectivity predicts spreading of alpha-synuclein pathology in fibril-injected mouse models: Involvement of retrograde and anterograde axonal propagation [PDF]
Neurobiology of Disease, 2020 In Parkinson's disease, some of the first alpha-synuclein aggregates appear in the olfactory system and the dorsal motor nucleus of the vagus nerve before spreading to connected brain regions.
Christopher Mezias +3 more
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C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. [PDF]
PLoS Genetics, 2008 Inclusions in the brain containing alpha-synuclein are the pathological hallmark of Parkinson's disease, but how these inclusions are formed and how this links to disease is poorly understood. We have developed a C.
Tjakko J van Ham +5 more
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A split biotin ligase approach reveals proteins associated with oligomeric alpha-synuclein during aggregation [PDF]
Scientific ReportsLewy pathology can form over decades in patients with Lewy body diseases, but the causal cellular mechanisms associated with this process remain unclear.
Analiese R. Fernandes +13 more
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In-cell NMR characterization of the secondary structure populations of a disordered conformation of α-Synuclein within E. coli cells [PDF]
, 2013 α-Synuclein is a small protein strongly implicated in the pathogenesis of Parkinson’s disease and related neurodegenerative disorders. We report here the use of in-cell NMR spectroscopy to observe directly the structure and dynamics of this protein ...
A Binolfi +57 more
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Inhibition of calpain prevents manganese-induced cell injury and alpha-synuclein oligomerization in organotypic brain slice cultures. [PDF]
PLoS ONE, 2015 Overexposure to manganese has been known to promote alpha-synuclein oligomerization and enhance cellular toxicity. However, the exact mechanism of Mn-induced alpha-synuclein oligomerization is unclear.
Bin Xu +5 more
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Alpha-synuclein suppression by targeted small interfering RNA in the primate substantia nigra. [PDF]
PLoS ONE, 2010 The protein alpha-synuclein is involved in the pathogenesis of Parkinson's disease and other neurodegenerative disorders. Its toxic potential appears to be enhanced by increased protein expression, providing a compelling rationale for therapeutic ...
Alison L McCormack +5 more
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Preanalytical Stability of CSF Total and Oligomeric Alpha-Synuclein
Frontiers in Aging Neuroscience, 2021 Background: The role of cerebrospinal fluid (CSF) alpha-synuclein as a potential biomarker has been challenged mainly due to variable preanalytical measures between laboratories.
Ilham Y. Abdi +7 more
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Formation of toxic oligomeric alpha-synuclein species in living cells. [PDF]
PLoS ONE, 2008 Misfolding, oligomerization, and fibrillization of alpha-synuclein are thought to be central events in the onset and progression of Parkinson's disease (PD) and related disorders.
Tiago Fleming Outeiro +7 more
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Molecules, 2021 The accumulation of the various products of alpha-synuclein aggregation has been associated with the etiology and pathogenesis of several neurodegenerative conditions, including both familial and sporadic forms of Parkinson’s disease (PD) and dementia ...
Mae Upcott +2 more
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The HSP70 molecular chaperone is not beneficial in a mouse model of alpha-synucleinopathy. [PDF]
PLoS ONE, 2010 BACKGROUND: Aggregation and misfolded alpha-synuclein is thought to be central in the pathogenesis of Parkinson's disease (PD). Heat-shock proteins (HSPs) that are involved in refolding and degradation processes could lower the aggregate load of alpha ...
Derya R Shimshek +4 more
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