Results 11 to 20 of about 67,038 (301)

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

Neurobiology of Disease, 2011
Alpha-synuclein aggregation plays a central role in Parkinson's disease pathology. Direct transmission of alpha-synuclein from pathologically affected to healthy unaffected neurons may be important in the anatomical spread of the disease through the ...
Lydia Alvarez-Erviti, Yiqi Seow, Anthony H. Schapira, Chris Gardiner, Ian L. Sargent, Matthew J.A. Wood, J. Mark Cooper   +6 more
doaj   +3 more sources

Alpha synuclein and inflammaging

Heliyon
The α-synuclein protein is an established molecule in Lewy body pathology, especially Parkinson's disease (PD). While the pathological role of α-synuclein (α-syn) in PD has been well described, novel evidence may suggest that α-syn interacts with ...
Geneviève L. Putnam, Robert W. Maitta
doaj   +2 more sources

Microtubule depolymerization potentiates alpha-synuclein oligomerization [PDF]

Frontiers in Aging Neuroscience, 2010
Parkinson’s disease (PD) is associated with perturbed mitochondria function and alpha-synuclein fibrillization. We evaluated potential mechanistic links between mitochondrial dysfunction and alpha-synuclein aggregation.
Russell H Swerdlow, Catarina Oliveira
doaj   +3 more sources

Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein

Scientific Reports, 2022
AbstractParkinson′s disease (PD) pathology progresses throughout the nervous system affecting numerous neuronal structures. It has been postulated that the progression of the pathology is based on a prion-like disease mechanism partly due to the seeding effect of endocytosed alpha-synuclein (ASYN) on the endogenous ASYN. The appearance of the pathology
Yanina Dening, Theresa Straßl, Viktoria Ruf, Petra Dirscherl, Alexandra Chovsepian, Alicia Stievenard, Amit Khairnar, Felix Schmidt, Florian Giesert, Jochen Herms, Johannes Levin, Marianne Dieterich, Peter Falkai, Daniela Vogt Weisenhorn, Wolfgang Wurst, Armin Giese, Francisco Pan-Montojo   +16 more
openaire   +6 more sources

Nitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats. [PDF]

PLoS ONE, 2010
BACKGROUND: The pathology of Parkinson's disease (PD) is characterized by the degeneration of the nigrostriatal dopaminergic pathway, as well as the formation of intraneuronal inclusions known as Lewy bodies and Lewy neurites in the substantia nigra ...
Zhongwang Yu, Xiaohui Xu, Zhenghua Xiang, Jianfeng Zhou, Zhaohuan Zhang, Chun Hu, Cheng He   +6 more
doaj   +1 more source

Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. [PDF]

PLoS ONE, 2009
In synucleinopathies, including Parkinson's disease, partially ubiquitylated alpha-synuclein species phosphorylated on serine 129 (P(S129)-alpha-synuclein) accumulate abnormally.
Margot Fournier, Jérémie Vitte, Jérôme Garrigue, Dominique Langui, Jean-Philippe Dullin, Françoise Saurini, Naïma Hanoun, Fernando Perez-Diaz, Fabien Cornilleau, Chantal Joubert, Héctor Ardila-Osorio, Sabine Traver, René Duchateau, Cécile Goujet-Zalc, Katerina Paleologou, Hilal A Lashuel, Christian Haass, Charles Duyckaerts, Charles Cohen-Salmon, Philipp J Kahle, Michel Hamon, Alexis Brice, Olga Corti   +22 more
doaj   +1 more source

Anti-α-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease

Neurobiology of Disease, 2023
Parkinson's disease (PD), a neurodegenerative disease affecting dopaminergic (DA) neurons, is characterized by decline of motor function and cognition. Dopaminergic cell loss is associated with accumulation of toxic alpha synuclein aggregates.
Robert Brendza, Xiaoying Gao, Kimberly L. Stark, Han Lin, Seung-Hye Lee, Changyun Hu, Hao Cai, Danielle DiCara, Yi-Chun Hsiao, Hai Ngu, Oded Foreman, Miriam Baca, Monika Dohse, Jean-Phillipe Fortin, Racquel Corpuz, Dhaya Seshasayee, Amy Easton, Gai Ayalon, Isidro Hötzel, Ben Chih   +19 more
doaj   +1 more source

Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells [PDF]

Neuroscience Letters, 2008
Alpha-synuclein (alpha-syn) is implicated in the pathogenesis of Parkinson's disease (PD). Mutations in alpha-syn gene or alpha-syn locus (SNCA) triplication are associated with mitochondrial abnormalities and early onset of familial PD. The goals of the present study were to examine whether alpha-syn is localized in the mitochondria of alpha-syn ...
Shaik, Shavali, Holly M, Brown-Borg, Manuchair, Ebadi, James, Porter   +3 more
openaire   +2 more sources

Calcium: Alpha-Synuclein Interactions in Alpha-Synucleinopathies [PDF]

Frontiers in Neuroscience, 2016
Aggregation of the pre-synaptic protein, α-synuclein (α-syn), is the key etiological factor in Parkinson's disease (PD) and other alpha-synucleinopathies, such as multiple system atrophy (MSA) and Dementia with Lewy bodies (DLB). Various triggers for pathological α-syn aggregation have been elucidated, including post-translational modifications ...
Rcom-H'cheo-Gauthier, Alexandre N, Osborne, Samantha L, Meedeniya, Adrian CB, Pountney, Dean L   +3 more
openaire   +4 more sources

Synapsin Condensates Recruit alpha-Synuclein

Journal of Molecular Biology, 2021
Neurotransmission relies on the tight spatial and temporal regulation of the synaptic vesicle (SV) cycle. Nerve terminals contain hundreds of SVs that form tight clusters. These clusters represent a distinct liquid phase in which one component of the phase are SVs and the other synapsin 1, a highly abundant synaptic protein.
Hoffmann, Christian, Sansevrino, Roberto, Morabito, Giuseppe, Logan, Chinyere, Vabulas, R Martin, Ulusoy, Ayse, Ganzella, Marcelo, Milovanovic, Dragomir   +7 more
openaire   +4 more sources