Results 101 to 110 of about 27,933 (291)

Small RNA analysis in Sindbis virus infected human HEK293 cells [PDF]

, 2013
In contrast to the defence mechanism of RNA interference (RNAi) in plants and invertebrates, its role in the innate response to virus infection of mammals is a matter of debate.
A Chakrabarti, A Mortazavi, A Saumet, Andras Donaszi-Ivanov, BC Ho, BR Cullen, BR tenOever, CL Campbell, CM Cirimotich, CW Burke, E Gottwein, EG Strauss, EM Morazzani, ER Mardis, EY Choy, F Ma, F Weber, G Gatto, G Szittya, I Mohorianu, I Mohorianu, IP Greene, Irina Mohorianu, J Fang, JI Henke, JK Ahluwalia, JR Abend, JY Leung, K Prufer, KJ Ishii, KL McKnight, KM Myles, KW Witwer, L Du, M Hariharan, MB Stocks, MC Saleh, ML Metzker, MP Gantier, N Vodovar, P Parameswaran, Penny P. Powell, PV Maillard, RL Pilcher, RL Skalsky, RP Kincaid, RW Williams, S Griffiths-Jones, S Koyama, S Moxon, SW Ding, T Kawai, Tamas Dalmay, V Stollar, W Hou, WB Klimstra, X Lei, Y Kim, Y Li, YQ Wu, Zach N. Adelman, ZN Adelman   +61 more
core   +3 more sources

Cross-utilisation of template RNAs by alphavirus replicases

PLoS Pathogens, 2020
Most alphaviruses (family Togaviridae) including Sindbis virus (SINV) and other human pathogens, are transmitted by arthropods. The first open reading frame in their positive strand RNA genome encodes for the non-structural polyprotein, a precursor to ...
L. Lello, Age Utt, K. Bartholomeeusen, Sainan Wang, Kai Rausalu, Catherine Kendall, S. Coppens, R. Fragkoudis, A. Tuplin, L. Alphey, K. Ariën, A. Merits   +11 more
semanticscholar   +1 more source

Betanodavirus Quantification and IFN I‐Antagonism Detection Using Luciferase Reporter Systems Based on Fish mx Promoters

Journal of Fish Diseases, Volume 48, Issue 12, December 2025.
ABSTRACT Mx genes display strong and quick induction in response to viral infections, which varies according to the viral virulence; furthermore, mx transcription is blocked by several viruses as part of their immune evasion strategies. Therefore, the level and time course of mx induction reflect virus–host interplay. This idea prompted the development
Daniel Álvarez‐Torres, Patricia Moreno, Esther García‐Rosado, M. Carmen Alonso, Julia Béjar   +4 more
wiley   +1 more source

Arthritogenic Alphavirus-Induced Immunopathology and Targeting Host Inflammation as A Therapeutic Strategy for Alphaviral Disease

Viruses, 2019
Arthritogenic alphaviruses are a group of medically important arboviruses that cause inflammatory musculoskeletal disease in humans with debilitating symptoms, such as arthralgia, arthritis, and myalgia.
Helen Mostafavi, Eranga Abeyratne, Ali Zaid, Adam Taylor   +3 more
doaj   +1 more source

Defined mutations in the 5' nontranslated sequence of Sindbis virus RNA [PDF]

, 1990
We have constructed 24 deletion mutants which contain deletions of from 1 to 15 nucleotides in the 5' nontranslated region of Sindbis virus RNA and tested the effect of these mutations on virus replication.
Niesters, Hubert G. M., Strauss, James H.   +1 more
core   +2 more sources

New insights into control of arbovirus replication and spread by insect RNA interference pathways [PDF]

, 2012
Arthropod-borne (arbo) viruses are transmitted by vectors, such as mosquitoes, to susceptible vertebrates. Recent research has shown that arbovirus replication and spread in mosquitoes is not passively tolerated but induces host responses to control ...
Andersson, Angelini, Angelini, Arensburger, Arensburger, Attarzadeh-Yazdi, Berry, Blevins, Brackney, Chung, Cirimotich, Cohen, Czech, Ding, Dubrulle, Fagegaltier, Flynt, Franz, Ghildiyal, Henke, Holt, Hussain, Hussain, Iwasaki, Kaminker, Kawamura, Keene, Kwon, Lagos-Quintana, Li, Lim, Lucchetta, Mendes, Morazzani, Mueller, Myles, Nene, Qi, Rezza, Ruby, Saleh, Sanchez-Vargas, Schwarz, Selbach, Sijen, Siu, Skalsky, Tam, Thibault, Vodovar, Watanabe, Waterhouse, Wu, Yan, Zeiner, Zeng   +55 more
core   +3 more sources

Endemic and Epidemic Human Alphavirus Infections in Eastern Panama: An Analysis of Population-Based Cross-Sectional Surveys

bioRxiv, 2020
Background Madariaga virus (MADV), has recently been associated with severe human disease in Panama, where the closely related Venezuelan equine encephalitis virus (VEEV) also circulates. In June, 2017, a fatal MADV infection was confirmed in a community
J. Carrera, Z. Cucunubá, K. Neira, B. Lambert, Y. Pittí, C. Jackman, Jesus Liscano, J. Garzon, Davis Beltrán, Luisa Collado-Mariscal, L. Saenz, N. Sosa, Luis D. Rodriguez-Guzman, P. González, Andrés G. Lezcano, R. Pereyra-Elías, Anayansi Valderrama, S. Weaver, A. Vittor, B. Armién, J. Pascale, C. Donnelly   +21 more
semanticscholar   +1 more source

Controlled Field Trial of Pancreas Disease Vaccines in Farmed Atlantic Salmon: Effects on Growth and Mortality During a SAV2 Outbreak

Journal of Fish Diseases, Volume 48, Issue 12, December 2025.
ABSTRACT Pancreas disease (PD), caused by salmonid alphavirus (SAV), is a concern for salmon aquaculture in Scotland, Ireland and Norway. This article presents results from a controlled field trial monitoring three study groups from vaccination to harvest.
Jostein Mulder Pettersen, Marte Follesø Sønnervik, Marius Karlsen, Hege Jørstad Sekkenes, Geir Schriwer, Petter Gjesdal, Ane Sandtrø, Magnus Vikan Røsæg   +7 more
wiley   +1 more source

Imaging the Alphavirus Exit Pathway [PDF]

Journal of Virology, 2014
ABSTRACT Alphaviruses are small enveloped RNA viruses with highly organized structures that exclude host cell proteins. They contain an internal nucleocapsid and an external lattice of the viral E2 and E1 transmembrane proteins. Alphaviruses bud from the plasma membrane (PM), but the process and dynamics of alphavirus assembly and budding are
Maria Guadalupe, Martinez, Erik-Lee, Snapp, Geoffrey S, Perumal, Frank P, Macaluso, Margaret, Kielian   +4 more
openaire   +3 more sources

Structure‐Based Rational Design of a Selective Hydrolase Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus‐2 Nsp3 Macrodomain

ChemBioChem, Volume 26, Issue 23, November 27, 2025.
Structure‐guided design of a sulfamoyl‐modified analog of GS‐441524 yielded a selective, high‐affinity inhibitor of the SARS‐CoV‐2 macrodomain Nsp3b. The compound occupies the phosphate‐binding pocket, forming a stabilizing hydrogen‐bond network that enhances binding affinity (K_D = 0.86 μM).
Robin Krishnathas, Konstantin S. Mineev, Nikolaos K. Fourkiotis, Franck Touret, Christos Sideras‐Bisdekis, Aikaterini C. Tsika, Santosh Lakshmi Gande, Verena Linhard, Sridhar Sreeramulu, Frank Lennartz, Manfred S. Weiss, Bruno Coutard, Georgios A. Spyroulias, Harald Schwalbe   +13 more
wiley   +1 more source