Results 101 to 110 of about 28,174 (288)

Alphavirus Particles Can Assemble with an Alternate Triangulation Number

Viruses, 2022
Alphaviruses are spherical, enveloped RNA viruses primarily transmitted by mosquitoes, and cause significant arthritogenic and neurotropic disease in humans and livestock.
Jason T. Kaelber, David Chmielewski, Wah Chiu, Albert J. Auguste   +3 more
doaj   +1 more source

A Viral mRNA Motif at the 3′-Untranslated Region that Confers Translatability in a Cell-Specific Manner. Implications for Virus Evolution [PDF]

, 2016
Sindbis virus (SINV) mRNAs contain several motifs that participate in the regulation of their translation. We have discovered a motif at the 3′ untranslated region (UTR) of viral mRNAs, constituted by three repeated sequences, which is involved in the ...
Carrasco, Luis, Garcia-Moreno, Manuel, Sanz, Miguel Angel   +2 more
core   +2 more sources

Clinical, Serological, and Molecular Profile of Dengue Patients With Warning Signs During the 2024 Outbreak in Belo Horizonte, Brazil

Journal of Medical Virology, Volume 98, Issue 1, January 2026.
ABSTRACT Dengue poses a significant arboviral threat in Brazil, with 2024 recording the largest outbreak to date. This prospective observational study was conducted during the 2024 outbreak with unvaccinated patients at Eduardo de Menezes Hospital, Belo Horizonte.
Samille Henriques Pereira, Ana Paula Moreira Franco‐Luiz, Camila Tita Nogueira, Guilherme Otávio Varino Cornélio, Adelina Machado de Carvalho Nogueira, Vírginia Antunes de Andrade, Silvia Hees de Carvalho, Karen Cecília de Lima Torres, Vanessa Peruhype‐Magalhães, Olindo Assis Martins‐Filho, Jordana Grazziela Alves Coelho‐dos‐Reis, Andréa Teixeira‐Carvalho, Flávio Guimarães da Fonseca, Pedro Augusto Alves   +13 more
wiley   +1 more source

Arthritogenic Alphavirus-Induced Immunopathology and Targeting Host Inflammation as A Therapeutic Strategy for Alphaviral Disease

Viruses, 2019
Arthritogenic alphaviruses are a group of medically important arboviruses that cause inflammatory musculoskeletal disease in humans with debilitating symptoms, such as arthralgia, arthritis, and myalgia.
Helen Mostafavi, Eranga Abeyratne, Ali Zaid, Adam Taylor   +3 more
doaj   +1 more source

Defined mutations in the 5' nontranslated sequence of Sindbis virus RNA [PDF]

, 1990
We have constructed 24 deletion mutants which contain deletions of from 1 to 15 nucleotides in the 5' nontranslated region of Sindbis virus RNA and tested the effect of these mutations on virus replication.
Niesters, Hubert G. M., Strauss, James H.   +1 more
core   +2 more sources

Small RNA analysis in Sindbis virus infected human HEK293 cells [PDF]

, 2013
In contrast to the defence mechanism of RNA interference (RNAi) in plants and invertebrates, its role in the innate response to virus infection of mammals is a matter of debate.
A Chakrabarti, A Mortazavi, A Saumet, Andras Donaszi-Ivanov, BC Ho, BR Cullen, BR tenOever, CL Campbell, CM Cirimotich, CW Burke, E Gottwein, EG Strauss, EM Morazzani, ER Mardis, EY Choy, F Ma, F Weber, G Gatto, G Szittya, I Mohorianu, I Mohorianu, IP Greene, Irina Mohorianu, J Fang, JI Henke, JK Ahluwalia, JR Abend, JY Leung, K Prufer, KJ Ishii, KL McKnight, KM Myles, KW Witwer, L Du, M Hariharan, MB Stocks, MC Saleh, ML Metzker, MP Gantier, N Vodovar, P Parameswaran, Penny P. Powell, PV Maillard, RL Pilcher, RL Skalsky, RP Kincaid, RW Williams, S Griffiths-Jones, S Koyama, S Moxon, SW Ding, T Kawai, Tamas Dalmay, V Stollar, W Hou, WB Klimstra, X Lei, Y Kim, Y Li, YQ Wu, Zach N. Adelman, ZN Adelman   +61 more
core   +3 more sources

ADP-ribosyl–binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Alphaviruses are mosquito-borne RNA viruses that cause encephalitis, rash, and arthritis. Alphavirus nonstructural protein 3 (nsP3) has a highly conserved macrodomain that can bind and remove ADP-ribose (ADPr) residues from ADP-ribosylated ...
Rachy Abraham, D. Hauer, R. McPherson, Age Utt, I. T. Kirby, Michael S. Cohen, A. Merits, A. Leung, D. Griffin   +8 more
semanticscholar   +1 more source

Strategic Preparedness of Broad‐Spectrum Antivirals for Rapid Response Towards Next Pandemics

Small Science, Volume 6, Issue 1, January 2026.
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
Sanoj Rejinold N, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source

Metabarcoding Reveals a Potentially Undescribed Columnaris‐Causing Bacterium in Peracute Skin Disease of Rainbow Trout (Oncorhynchus mykiss, Walbaum)

Journal of Fish Diseases, Volume 49, Issue 1, January 2026.
ABSTRACT Columnaris‐causing bacteria (CCB) represent a group of four Flavobacterium species, previously classified under Flavobacterium columnaris, causing a threatening condition in salmonid farming characterised by cutaneous and gill lesions, commonly referred to as ‘saddleback disease’. A peracute skin disease outbreak with high mortality in rainbow
Samuele Zamparo, Ginevra Brocca, Fabio Marroni, Slobodanka Radovic, Ciro Castellano, Diana Torge, Serena Bianchi, David Groman, Guido Macchiarelli, Luisa Vera Muscatello, Donatella Volpatti, Massimo Orioles   +11 more
wiley   +1 more source

Mutagenesis of the conserved 51-nucleotide region of Sindbis virus [PDF]

, 1990
We have constructed 25 site-specific mutations in a domain of 51 nucleotides in Sindbis virus that is highly conserved among all alphaviruses sequenced to date.
Niesters, Hubert G. M., Strauss, James H.   +1 more
core