Mapping of RNA- temperature-sensitive mutants of Sindbis virus: assignment of complementation groups A, B, and G to nonstructural proteins [PDF]
, 1989 Four complementation groups of temperature-sensitive (ts) mutants of Sindbis virus that fail to make RNA at the nonpermissive temperature are known, and we have previously shown that group F mutants have defects in nsP4.
Hahn, Young S. +2 more
core +1 more source
VCP/p97 Is a Proviral Host Factor for Replication of Chikungunya Virus and Other Alphaviruses
Frontiers in Microbiology, 2019 The evolutionarily conserved AAA+ ATPase valosin-containing protein (VCP) was previously shown to be a proviral host factor for several viruses from different viral families such as Flaviviridae, Picornaviridae, and Herpesviridae. VCP was shown to affect
Guillaume Carissimo +10 more
doaj +1 more source
Sindbis virus ts103 has a mutation in glycoprotein E2 that leads to defective assembly of virions [PDF]
, 1989 Sindbis virus mutant ts103 is aberrant in the assembly of virus particles. During virus budding, proper nucleocapsid-glycoprotein interactions fail to occur such that particles containing many nucleocapsids are formed, and the final yield of virus is low.
Hahn, Chang S. +4 more
core
Diversity in viral anti-PKR mechanisms: A remarkable case of evolutionary convergence [PDF]
, 2015 Most viruses express during infection products that prevent or neutralize the effect of the host dsRNA activated protein kinase (PKR). Translation of Sindbis virus (SINV) mRNA escapes to PKR activation and eIF2 phosphorylation in infected cells by a ...
Domingo-Gil, Elena +4 more
core +1 more source
Journal of Medical Virology, Volume 97, Issue 9, September 2025.ABSTRACT In the wake of the COVID‐19 pandemic, awareness of emerging pathogens has significantly increased, prompting greater investment in research and preparedness. In this context, arboviral diseases are recognized as unmet medical challenges due to their rapid spread. Notably, the geographical range of several flaviviral diseases is expanding: Zika
Erika Plicanti +11 more
wiley +1 more source
Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses [PDF]
, 2017 The recent outbreak of infection with Zika virus (ZIKV; Flaviviridae) has attracted attention to this previously neglected mosquito-borne pathogen and the need for efficient therapies.
Donald, Claire L. +4 more
core +1 more source
The growth of arthralgic Ross River virus is restricted in human monocytic cells [PDF]
, 2016 International audienceAlphaviruses such as Chikungunya and Ross River (RRV) viruses are associated with persistent arthritisand arthralgia in humans. Monocytes and macrophages are believed to play an important role in alphaviralarthritides. In this study,
Belarbi, Essia +7 more
core +2 more sources
Increasing Occurrence of Marburg Virus Outbreaks in Africa: Risk Assessment for Public Health
Microbial Biotechnology, Volume 18, Issue 9, September 2025.Bat and Marburg virus (Filovirus). Left: A Rousettus aegyptiacus bat; Center: a distribution map of R. aegyptiacus; Right: EM of Marburg virus. (figure credits: Left Wikipedia Nilflughund Lithuanian Zoological Gardens, Center; Center: Wikipedia Nilflughund IUCN Red List of Threatened Species, right Wikipedia Marburg virus CDC Fred Murphy; J.
Harald Brüssow
wiley +1 more source
Sindbis Virus Infection in Resident Birds, Migratory Birds, and Humans, Finland
Emerging Infectious Diseases, 2008 Sindbis virus (SINV), a mosquito-borne virus that causes rash and arthritis, has been causing outbreaks in humans every seventh year in northern Europe.
Satu Kurkela +9 more
doaj +1 more source
Disruption of the Opal Stop Codon Attenuates Chikungunya Virus-Induced Arthritis and Pathology
mBio, 2017 Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for several significant outbreaks of debilitating acute and chronic arthritis and arthralgia over the past decade.
Jennifer E. Jones +12 more
doaj +1 more source