Results 81 to 90 of about 16,243 (206)

Alphavirus Infection: Host Cell Shut-Off and Inhibition of Antiviral Responses

Viruses, 2016
Alphaviruses cause debilitating disease in humans and animals and are transmitted by blood-feeding arthropods, typically mosquitoes. With a traditional focus on two models, Sindbis virus and Semliki Forest virus, alphavirus research has significantly ...
Jelke J. Fros, Gorben P. Pijlman
doaj   +1 more source

Ultrastructural morphogenesis of salmonid alphavirus 1

, 2012
Studies on the ultrastructural morphogenesis of viruses give an insight into how the host cell mechanisms are utilized for new virion synthesis. A time course examining salmonid alphavirus 1 (SAV 1) assembly was performed by culturing the virus on ...
Adams, Alexandra, Richards, Randolph, Thompson, Kimberly, Herath, Tharangani, Ferguson, Hugh   +4 more
core   +1 more source

VCP/p97 Is a Proviral Host Factor for Replication of Chikungunya Virus and Other Alphaviruses

Frontiers in Microbiology, 2019
The evolutionarily conserved AAA+ ATPase valosin-containing protein (VCP) was previously shown to be a proviral host factor for several viruses from different viral families such as Flaviviridae, Picornaviridae, and Herpesviridae. VCP was shown to affect
Guillaume Carissimo, Yi-Hao Chan, Yi-Hao Chan, Age Utt, Tze-Kwang Chua, Farhana Abu Bakar, Farhana Abu Bakar, Andres Merits, Lisa F. P. Ng, Lisa F. P. Ng, Lisa F. P. Ng   +10 more
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Granulocyte colony-stimulating factor protects against acute systemic alphavirus disease in a type I IFN-dependent manner

Frontiers in Immunology
IntroductionArthritogenic alphaviruses, including chikungunya (CHIKV) and Mayaro virus (MAYV), cause disease characterized by fever, rash, and incapacitating joint pain.
Muddassar Hameed, Muddassar Hameed, Muddassar Hameed, Pallavi Rai, Pallavi Rai, Md Shakhawat Hossain, Md Shakhawat Hossain, Andrea Daamen, Peter E. Lipsky, James Weger-Lucarelli, James Weger-Lucarelli   +10 more
doaj   +1 more source

siRNA Screen Identifies Trafficking Host Factors that Modulate Alphavirus Infection. [PDF]

, 2016
Little is known about the repertoire of cellular factors involved in the replication of pathogenic alphaviruses. To uncover molecular regulators of alphavirus infection, and to identify candidate drug targets, we performed a high-content imaging-based ...
Gianluca Pegoraro, Chih-Yuan Chiang, Sina Bavari (154739), Christopher L Cooper, Jeremiah C. Clester (348526), Lián Dǒng (2584498), Jens H Kuhn, Mei G Sun, Rouzbeh Zamani (2584486), David P Langan, David P. Langan (2584501), Krishna Kota (348527), Jens H. Kuhn (200537), Gianluca Pegoraro (182347), Krishna Kota, Lián D Ng, Lucas Jozwick (2584483), Rouzbeh Zamani, Kathleen A Kuehl, Shu Qìng Yú, Shuǐqìng Yú (2220817), Duane Courier, Yíngyún Caì (2220820), Robin Burk (2220811), Yíngyún Caì, Sheli R Radoshitzky, Knashka Underwood, Robin Burk, Sheli R. Radoshitzky (233641), Sina Bavari, Xiǎolì Chī (2584495), Christopher L. Cooper (2584507), Mei G. Sun (2584510), Kathleen A. Kuehl (2584489), Jeremiah C Clester, Duane Courier (2584504), Knashka Underwood (2584480), Xi Olì Chī, Chih-Yuan Chiang (2584492), Lucas Jozwick   +39 more
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Interactions involved in pH protection of the alphavirus fusion protein [PDF]

, 2015
The alphavirus membrane protein E1 mediates low pH-triggered fusion of the viral and endosome membranes during virus entry. During virus biogenesis E1 associates as a heterodimer with the transmembrane protein p62. Late in the secretory pathway, cellular
Fields, Whitney, Kielian, Margaret
core   +1 more source

ANALISIS MODEL MATEMATIKA PENGUJI EFEKTIVITAS ONCOLYTIC PADA ALPHAVIRUS [PDF]

, 2019
Kanker merupakan salah satu penyakit penyebab kematian dengan jumlah terbesar di seluruh dunia. Oncolotyc virotherapy adalah metode pengobatan yang menggunakan replikasi virus sebagai agen antineoplastik yang selektif, yang masih dalam tahap ...
RAHMAWATI NUR FADZILLAH, 081211233030
core   +1 more source

nsP3-FXR co-condensation enables alphavirus replication and reveals a targetable alphavirus vulnerability

Cell Reports
Summary: Alphaviruses are mosquito-borne RNA viruses that pose a significant threat to humans, with risks worsened by global warming. Non-structural protein 3 (nsP3) is critical for alphavirus infection, yet its precise roles remain poorly defined. Using
Yifan Xie, Jie Cao, Xinya Yang, Ruzhu Hou, Suhong Qian, Guojie Wang, Shiyu Deng, Luo-Na Lin, Yue Liu, Peiguo Yang, Rong Zhang, Qiang Ding, Peng Sun, Wenchun Fan   +13 more
doaj   +1 more source

PLoS One [PDF]

We established a rapid, specific technique for detecting alphaviruses using a replicon-defective reporter gene assay derived from the Sindbis virus XJ-160.

core  

Sindbis Virus Infection in Resident Birds, Migratory Birds, and Humans, Finland

Emerging Infectious Diseases, 2008
Sindbis virus (SINV), a mosquito-borne virus that causes rash and arthritis, has been causing outbreaks in humans every seventh year in northern Europe.
Satu Kurkela, Osmo Rätti, Eili Huhtamo, Nathalie Y. Uzcátegui, J. Pekka Nuorti, Juha Laakkonen, Tytti Manni, Pekka Helle, Antti Vaheri, Olli Vapalahti   +9 more
doaj   +1 more source