Results 81 to 90 of about 23,819 (265)

Suppression of steady-state, but not stimulus-induced NF-kappaB activity inhibits alphavirus-induced apoptosis. [PDF]

, 1998
Recent studies have established cell type- specific, proapoptotic, or antiapoptotic functions for the transcription factor NF-kappaB. In each of these studies, inhibitors of NF-kappaB activity have been present before the apoptotic stimulus, and so the ...
DiDonato, JA, Hardwick, JM, Hoffmann, A, Lin, KI, Ratan, RR   +4 more
core  

Semliki Forest virus induced, immune mediated demyelination: the effect of irradiation [PDF]

, 1987
International audienceThe Dark Energy Camera has captured a large set of images as part of Science Verification (SV) for the Dark Energy Survey (DES). The SV footprint covers a large portion of the outer Large Magellanic Cloud (LMC), providing photometry
Abbott, T. M. C., Allam, S. S., Annis, J., Balbinot, Eduardo, Benoit-Levy, A., Bernstein, J. P., Bernstein, R. A., Bertin, E., Brooks, D., Buckley-Geer, E., Cunha, C. E., Da Costa, L. N., DePoy, D. L., Desai, S., Diehl, H. T., Doel, P., Drlica-Wagner, A., Estrada, J., Evrard, A. E., Finley, D. A., Flaugher, B., Frieman, J. A., Girardi, L., Gruen, D., Gruendl, R. A., Honscheid, K., James, D., Kuehn, K., Kuropatkin, N., Lahav, O., Maia, M. A. G., March, M., Marshall, J. L., Miller, C., Miquel, R., Neto, A. Fausti, Ogando, R., Peoples, J., Pieres, A., Plazas, A., Rosell, A. Carnero, Santiago, B. X., Scarpine, V., Schubnell, M., Sevilla-Noarbe, I., Smith, R. C., Soares-Santos, M., Suchyta, E., Swanson, M. E. C., Tarle, G., Tucker, D. L., Walker, A. R., Wechsler, R., Yanny, B., Zuntz, J.   +54 more
core   +4 more sources

Triple Burden in the Democratic Republic of Congo: Climate Change, Armed Conflict, and the Silent Spread of Arboviruses. A Narrative Review

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background The Democratic Republic of Congo (DRC) faces a “triple burden” of public health threats which includes climate change, protracted armed conflict, and the under‐recognized spread of arboviral diseases. Arboviruses, such as dengue, chikungunya, Zika, and yellow fever, are transmitted by Aedes aegypti and Aedes albopictus mosquitoes ...
Stanis Donnang, Hermann Yokolo, Dujardin Makeda, Joshua Ekouo, Zubayer Shams, Johan Armel Domga Kaptso, Josias Silatchom Kamgang, Yann Valerin Waffo, Christian Tague   +8 more
wiley   +1 more source

Adaptive changes in alphavirus mRNA translation allowed colonization of vertebrate hosts [PDF]

, 2012
Members of the Alphavirus genus are arboviruses that alternate replication in mosquitoes and vertebrate hosts. In vertebrate cells, the alphavirus resists the activation of antiviral RNA-activated protein kinase (PKR) by the presence of a prominent RNA
Ventoso, Iván
core   +2 more sources

Arthritogenic Alphavirus-Induced Immunopathology and Targeting Host Inflammation as A Therapeutic Strategy for Alphaviral Disease

Viruses, 2019
Arthritogenic alphaviruses are a group of medically important arboviruses that cause inflammatory musculoskeletal disease in humans with debilitating symptoms, such as arthralgia, arthritis, and myalgia.
Helen Mostafavi, Eranga Abeyratne, Ali Zaid, Adam Taylor   +3 more
doaj   +1 more source

Oncolytic Therapy: Delivery System and New Therapeutic Strategies for Cancer

MedComm, Volume 7, Issue 4, April 2026.
This review summarizes recent advances in nanoparticle‐ and cell‐mediated OVs delivery strategies that improve biodistribution and tumor targeting while limiting immune clearance. It also examines combination approaches that enhance therapeutic efficacy through tumor microenvironment modulation or immune activation, thereby overcoming immunosuppression
Sikan Jin, Yi Zhang, Ziling Zhou, Yaqi Zhang, Ting Yu, Rui Xu, Lin Xu, Jidong Zhang, Longze Zhang, Shan Yang, Xianyao Wang   +10 more
wiley   +1 more source

Alphavirus vectors for cancer therapy

Virus Research, 2010
Alphaviruses contain a single strand RNA genome that can be easily modified to express heterologous genes at very high levels in a broad variety of cells, including tumor cells. Alphavirus vectors can be used as viral particles containing a packaged vector RNA, or directly as nucleic acids in the form of RNA or DNA. In the latter case alphavirus RNA is
Jose I, Quetglas, Marta, Ruiz-Guillen, Alejandro, Aranda, Erkuden, Casales, Jaione, Bezunartea, Cristian, Smerdou   +5 more
openaire   +2 more sources

Phylogenetic and Timescale Analysis of Barmah Forest Virus as Inferred from Genome Sequence Analysis

Viruses, 2020
Barmah Forest virus (BFV) is a medically important mosquito-borne alphavirus endemic to Australia. Symptomatic disease can be a major cause of morbidity, associated with fever, rash, and debilitating arthralgia.
Alice Michie, Timo Ernst, I-Ly Joanna Chua, Michael D. A. Lindsay, Peter J. Neville, Jay Nicholson, Andrew Jardine, John S. Mackenzie, David W. Smith, Allison Imrie   +9 more
doaj   +1 more source

Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection [PDF]

, 2012
Dynamic, mRNA-containing stress granules (SGs) form in the cytoplasm of cells under environmental stresses, including viral infection. Many viruses appear to employ mechanisms to disrupt the formation of SGs on their mRNAs, suggesting that they represent
Eng, Kai Er, Karlsson Hedestam, Gunilla B., Lulla, Aleksei, McInerney, Gerald M., Merits, Andres, Panas, Marc D., Varjak, Margus   +6 more
core   +1 more source

Antivirals Targeting Coronavirus RNA‐Dependent RNA Polymerase and Main Protease: From Mechanisms of Action to Outcomes in COVID‐19 Clinical Trials

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
The target sites of COVID‐19 antivirals discussed in the present opinion paper, namely the RNA dependent RNA polymerase Nsp12 and of the main viral protease Nsp5, are indicated by a red star in the overview of the replication cycle of coronavirus SARS‐CoV‐2.
Harald Brüssow
wiley   +1 more source