Results 81 to 90 of about 16,582 (211)
Advanced Science, Volume 13, Issue 38, 9 July 2026.By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang +13 more
wiley +1 more source
Alphavirus Infection: Host Cell Shut-Off and Inhibition of Antiviral Responses
Viruses, 2016 Alphaviruses cause debilitating disease in humans and animals and are transmitted by blood-feeding arthropods, typically mosquitoes. With a traditional focus on two models, Sindbis virus and Semliki Forest virus, alphavirus research has significantly ...
Jelke J. Fros, Gorben P. Pijlman
doaj +1 more source
Schematic diagram of Alphavirus detection using defective XJ-160 replicons.
, 2013 Due to the deletion in the non-structural protein coding region, the defective XJ-160 replicons (pVaXJ-EGFPΔ nsp4 and pVaXJ-GLucΔ nsp4) failed to express the reporter genes efficiently. When cells were infected with alphavirus, the alphavirus synthesized
Wuyang Zhu (329855) +9 more
core +1 more source
Frontiers in ImmunologyIntroductionArthritogenic alphaviruses, including chikungunya (CHIKV) and Mayaro virus (MAYV), cause disease characterized by fever, rash, and incapacitating joint pain.
Muddassar Hameed +10 more
doaj +1 more source
VCP/p97 Is a Proviral Host Factor for Replication of Chikungunya Virus and Other Alphaviruses
Frontiers in Microbiology, 2019 The evolutionarily conserved AAA+ ATPase valosin-containing protein (VCP) was previously shown to be a proviral host factor for several viruses from different viral families such as Flaviviridae, Picornaviridae, and Herpesviridae. VCP was shown to affect
Guillaume Carissimo +10 more
doaj +1 more source
Alphavirus vectors for cancer therapy
Virus Research, 2010 Alphaviruses contain a single strand RNA genome that can be easily modified to express heterologous genes at very high levels in a broad variety of cells, including tumor cells. Alphavirus vectors can be used as viral particles containing a packaged vector RNA, or directly as nucleic acids in the form of RNA or DNA. In the latter case alphavirus RNA is
Jose I, Quetglas +5 more
openaire +2 more sources
Mosquito Saliva Reshapes Alphavirus Infection and Immunopathogenesis
, 2018 Alphaviruses are transmitted to humans via bites of infected mosquitoes. Although alphaviruses have caused a wide range of outbreaks and crippling disease, the availability of licensed vaccines or antiviral therapies remains limited.
Lisa F. P. Ng +2 more
core +1 more source
Insect response to Alphavirus infection
, 2007 Invertebrate cells survive Alphavirus infections to establish viral persistence, in contrast to cell death seen soon after infection in mammalian cells.
Mudiganti, Usharani
core
Corrigendum: Death and gastrointestinal bleeding complicate encephalomyelitis in mice with delayed appearance of CNS IgM after intranasal alphavirus infection [PDF]
, 2018 Corrigendum to: Death and gastrointestinal bleeding complicate encephalomyelitis in mice with delayed appearance of CNS IgM after intranasal alphavirus ...
Griffin, Diane E +4 more
core +1 more source
Cell ReportsSummary: Alphaviruses are mosquito-borne RNA viruses that pose a significant threat to humans, with risks worsened by global warming. Non-structural protein 3 (nsP3) is critical for alphavirus infection, yet its precise roles remain poorly defined. Using
Yifan Xie +13 more
doaj +1 more source