Results 81 to 90 of about 15,159 (204)

The Poisson CUSUM Chart for Monitoring Small Counts: Addressing the Estimation Uncertainty

Biometrical Journal, Volume 68, Issue 2, April 2026.
ABSTRACT This study addresses the impact of estimating in‐control parameters on the performance of the Poisson cumulative sum (CUSUM) chart in detecting an increase in the mean when the counts are small. To reduce false signals induced by estimation uncertainty, recommendations prescribe impractically large sample sizes or propose methods that widen ...
Stan Heidema, Ivo V. Stoepker, Ralph Huits, Edwin R. van den Heuvel   +3 more
wiley   +1 more source

The Regulation of Translation in Alphavirus-Infected Cells [PDF]

Viruses, 2018
Sindbis virus (SINV) contains an RNA genome of positive polarity with two open reading frames (ORFs). The first ORF is translated from the genomic RNA (gRNA), rendering the viral non-structural proteins, whereas the second ORF is translated from a subgenomic mRNA (sgRNA), which directs the synthesis of viral structural proteins. SINV infection strongly
Luis Carrasco, Miguel Sanz, Esther González-Almela   +2 more
openaire   +4 more sources

Triple Burden in the Democratic Republic of Congo: Climate Change, Armed Conflict, and the Silent Spread of Arboviruses. A Narrative Review

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background The Democratic Republic of Congo (DRC) faces a “triple burden” of public health threats which includes climate change, protracted armed conflict, and the under‐recognized spread of arboviral diseases. Arboviruses, such as dengue, chikungunya, Zika, and yellow fever, are transmitted by Aedes aegypti and Aedes albopictus mosquitoes ...
Stanis Donnang, Hermann Yokolo, Dujardin Makeda, Joshua Ekouo, Zubayer Shams, Johan Armel Domga Kaptso, Josias Silatchom Kamgang, Yann Valerin Waffo, Christian Tague   +8 more
wiley   +1 more source

Alphavirus Infection: Host Cell Shut-Off and Inhibition of Antiviral Responses

Viruses, 2016
Alphaviruses cause debilitating disease in humans and animals and are transmitted by blood-feeding arthropods, typically mosquitoes. With a traditional focus on two models, Sindbis virus and Semliki Forest virus, alphavirus research has significantly ...
Jelke J. Fros, Gorben P. Pijlman
doaj   +1 more source

Oncolytic Therapy: Delivery System and New Therapeutic Strategies for Cancer

MedComm, Volume 7, Issue 4, April 2026.
This review summarizes recent advances in nanoparticle‐ and cell‐mediated OVs delivery strategies that improve biodistribution and tumor targeting while limiting immune clearance. It also examines combination approaches that enhance therapeutic efficacy through tumor microenvironment modulation or immune activation, thereby overcoming immunosuppression
Sikan Jin, Yi Zhang, Ziling Zhou, Yaqi Zhang, Ting Yu, Rui Xu, Lin Xu, Jidong Zhang, Longze Zhang, Shan Yang, Xianyao Wang   +10 more
wiley   +1 more source

Ultrastructural morphogenesis of salmonid alphavirus 1

, 2012
Studies on the ultrastructural morphogenesis of viruses give an insight into how the host cell mechanisms are utilized for new virion synthesis. A time course examining salmonid alphavirus 1 (SAV 1) assembly was performed by culturing the virus on ...
Adams, Alexandra, Richards, Randolph, Thompson, Kimberly, Herath, Tharangani, Ferguson, Hugh   +4 more
core   +1 more source

Mosquitoes as Vectors of Mycobacterium ulcerans Based on Analysis of Notifications of Alphavirus Infection and Buruli Ulcer, Victoria, Australia

Emerging Infectious Diseases
Alphavirus infections are transmitted by mosquitoes, but the mode of transmission for Mycobacterium ulcerans, which causes Buruli ulcer, is contested. Using notification data for Victoria, Australia, during 2017–2022, adjusted for incubation period, we ...
Andrew H. Buultjens, Ee Laine Tay, Aidan Yuen, N. Deborah Friedman, Timothy P. Stinear, Paul D.R. Johnson   +5 more
doaj   +1 more source

Mayaro virus: imported cases of human infection in São Paulo State, Brazil Vírus Mayaro: casos importados de infecção humana no Estado de São Paulo, Brasil

Revista do Instituto de Medicina Tropical de São Paulo, 2007
Mayaro virus (MAYV) is an arbovirus (Togaviridae: Alphavirus) enzootic in tropical South America and maintained in a sylvan cycle involving wild vertebrates and Haemagogus mosquitoes.
Terezinha Lisieux M. Coimbra, Cecília L. S. Santos, Akemi Suzuki, Selma M. C. Petrella, Ivani Bisordi, Adélia H. Nagamori, Antonia T. Marti, Raimundo N. Santos, Danya M. Fialho, Shirlene Lavigne, Marcia R. Buzzar, Iray M. Rocco   +11 more
doaj   +1 more source

Antivirals Targeting Coronavirus RNA‐Dependent RNA Polymerase and Main Protease: From Mechanisms of Action to Outcomes in COVID‐19 Clinical Trials

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
The target sites of COVID‐19 antivirals discussed in the present opinion paper, namely the RNA dependent RNA polymerase Nsp12 and of the main viral protease Nsp5, are indicated by a red star in the overview of the replication cycle of coronavirus SARS‐CoV‐2.
Harald Brüssow
wiley   +1 more source

Development of eNA Sampling for Early Detection of Pathogens in On‐Farm Water Sources

Environmental DNA, Volume 8, Issue 2, March/April 2026.
We compare four water‐sampling methods for detecting microbial and viral eNA in livestock troughs and show all approaches effectively recover community profiles, supporting flexible, field‐ready surveillance of livestock pathogens. ABSTRACT Early detection of livestock pathogens is critical for mitigating risk and implementing timely control or ...
Maxine P. Piggott, Allyson Malpartida
wiley   +1 more source