Results 71 to 80 of about 16,243 (206)

Challenges and emerging trends in fish vaccine platforms, delivery methods, and field performance for sustainable aquaculture: A scoping review

Journal of the World Aquaculture Society, Volume 57, Issue 4, August 2026.
Abstract Fish vaccination has been practiced globally for several decades and is increasingly recognized as a cornerstone of sustainable disease management in aquaculture, offering an effective alternative to antibiotic and chemotherapeutic use. This PRISMA‐ScR guided Scoping Review synthesized evidence from 173 peer‐reviewed studies and reports to ...
Fredrick Juma Syanya, Zachariy Oreko Winam, Paul Maina Mwangi, Harikrishnan Mahadevan, A. R. Nikhila Khanna, Mujeeb Rahiman K M, Megha Lovejan   +6 more
wiley   +1 more source

Phylogenetic and Timescale Analysis of Barmah Forest Virus as Inferred from Genome Sequence Analysis

Viruses, 2020
Barmah Forest virus (BFV) is a medically important mosquito-borne alphavirus endemic to Australia. Symptomatic disease can be a major cause of morbidity, associated with fever, rash, and debilitating arthralgia.
Alice Michie, Timo Ernst, I-Ly Joanna Chua, Michael D. A. Lindsay, Peter J. Neville, Jay Nicholson, Andrew Jardine, John S. Mackenzie, David W. Smith, Allison Imrie   +9 more
doaj   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, Volume 13, Issue 38, 9 July 2026.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Land‐Based Functional Rehabilitation Versus Aquatic Therapy on the Quality of Life of Individuals With Chronic Chikungunya: A Randomized Clinical Trial

Physiotherapy Research International, Volume 31, Issue 3, July 2026.
ABSTRACT Background and Purpose Chikungunya may progress to a chronic phase marked by persistent pain and functional impairment, reducing the quality of life. Exercise‐based rehabilitation is essential, though comparisons between different modalities remain scarce. Exercises in an aquatic environment can be designed as a task‐oriented intervention that
Oliva Maria da Silva Sousa, Marynara Fabíola Silva Araújo, Geilson Medeiros de Araújo, Hilmaynne Renaly Fonseca Fialho, Renata Newman Leite dos Santos Lucena, Eleazar Marinho de Freitas Lucena   +5 more
wiley   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, Volume 9, Issue 6, Page 1167-1179, June 2026.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Src Family Kinase Inhibitors Block Translation of Alphavirus Subgenomic mRNAs [PDF]

, 2019
Alphaviruses are arthropod-transmitted RNA viruses that can cause arthralgia, myalgia, and encephalitis in humans. Since the role of cellular kinases in alphavirus replication is unknown, we profiled kinetic changes in host kinase abundance and ...
DeFilippis, Victor R., Graves, Lee, Streblow, Daniel, Morrison, Thomas E., Heise, Mark T., Smith, Patricia, Kreklywich, Craig N., Streblow, Daniel N., Moorman, Nathaniel, Broeckel, Rebecca, Sarkar, Sanjay, Totonchy, Jennifer, May, Nicholas A.   +12 more
core   +1 more source

Mosquitoes as Vectors of Mycobacterium ulcerans Based on Analysis of Notifications of Alphavirus Infection and Buruli Ulcer, Victoria, Australia

Emerging Infectious Diseases
Alphavirus infections are transmitted by mosquitoes, but the mode of transmission for Mycobacterium ulcerans, which causes Buruli ulcer, is contested. Using notification data for Victoria, Australia, during 2017–2022, adjusted for incubation period, we ...
Andrew H. Buultjens, Ee Laine Tay, Aidan Yuen, N. Deborah Friedman, Timothy P. Stinear, Paul D.R. Johnson   +5 more
doaj   +1 more source

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, Volume 36, Issue 38, 11 May 2026.
ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based local
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Development and efficacy testing of broad alphavirus vaccines and antivirals and characterization of alphavirus neuroinvasion [PDF]

, 2016
2016 Spring.Includes bibliographical references.Alphaviruses are mosquito-borne pathogens that cause worldwide disease and death in humans and animals.
Olson, Ken, advisor, Rico, Amber, author, Chen, Chaoping, committee member, Powers, Ann, committee member, Ebel, Greg, committee member, Bowen, Richard, committee member   +5 more
core  

Dengue Virus Capsid Protein Interaction With Nucleic Acids

BioFactors, Volume 52, Issue 3, May/June 2026.
Binding of dengue virus capsid protein (DENV C) to ssDNA alters Trp fluorescence intensity, lifetime, and anisotropy, revealing structural rearrangements in the complex and suggesting a possible association with liquid–liquid phase separation (LLPS). ABSTRACT Dengue virus (DENV) transmission has greatly increased in the last decade, partly due to the ...
Nelly M. Silva, Ana S. Martins, Nina E. Karguth, Maria J. Sarmento, Francisco J. Enguita, Roland G. Huber, Ivo C. Martins, Nuno C. Santos   +7 more
wiley   +1 more source