Results 21 to 30 of about 17,945 (225)
Altered Spatial and Temporal Gait Parameters in Mice Infected with Ross River Virus
mSphere, 2021 Mouse models that accurately replicate the immunopathogenesis and clinical disease of alphavirus infection are vital to the preclinical development of therapeutic strategies that target alphavirus infection and disease.
Eranga Abeyratne +6 more
doaj +1 more source
Effects of Palmitoylation of Replicase Protein nsP1 on Alphavirus Infection
Journal of Virology, 2000 ABSTRACT The membrane-associated alphavirus RNA replication complex contains four virus-encoded subunits, the nonstructural proteins nsP1 to nsP4. Semliki Forest virus (SFV) nsP1 is hydrophobically modified by palmitoylation of cysteines 418 to 420.
Tero Ahola +6 more
openalex +4 more sources
Neurological Sequelae Resulting from Encephalitic Alphavirus Infection. [PDF]
Front Microbiol, 2016 The recent surge in viral clinical cases and associated neurological deficits have reminded us that viral infections can lead to detrimental, long-term effects, termed sequelae, in survivors. Alphaviruses are enveloped, single-stranded positive-sense RNA viruses in the Togaviridae family.
Ronca SE, Dineley KT, Paessler S.
europepmc +4 more sources
BHK-21 Cell Clones Differ in Chikungunya Virus Infection and MXRA8 Receptor Expression
Viruses, 2021 Baby hamster kidney-21 (BHK-21) cells are widely used to propagate and study many animal viruses using infection and transfection techniques. Among various BHK-21 cell clones, the fibroblast-like BHK-21/C-13 line and the epithelial-like BHK-21/WI-2 line ...
Peiqi Yin, Margaret Kielian
doaj +1 more source
The Regulation of Translation in Alphavirus-Infected Cells [PDF]
Viruses, 2018 Sindbis virus (SINV) contains an RNA genome of positive polarity with two open reading frames (ORFs). The first ORF is translated from the genomic RNA (gRNA), rendering the viral non-structural proteins, whereas the second ORF is translated from a subgenomic mRNA (sgRNA), which directs the synthesis of viral structural proteins. SINV infection strongly
Luis Carrasco +2 more
openaire +5 more sources
Cells, 2021 Alphaviruses are a group of arboviruses that generate chronic inflammatory rheumatisms in humans. Currently, no approved vaccines or antiviral therapies are available to prevent or treat alphavirus-induced diseases.
Anthony Dobi +3 more
doaj +1 more source
Alphavirus Transducing System: Tools for Visualizing Infection in Mosquito Vectors [PDF]
Journal of Visualized Experiments, 2010 Alphavirus transducing systems (ATSs) are important tools for expressing genes of interest (GOI) during infection. ATSs are derived from cDNA clones of mosquito-borne RNA viruses (genus Alphavirus; family Togaviridae). The Alphavirus genus contains about 30 different mosquito-borne virus species.
Aaron T. Phillips +4 more
openalex +4 more sources
DDX56 Binds to Chikungunya Virus RNA To Control Infection
mBio, 2020 DEAD box RNA helicases regulate diverse facets of RNA biology. Proteins of this family carry out essential cellular functions, and emerging literature is revealing additional roles in immune defense.
Frances Taschuk +3 more
doaj +1 more source
Death and gastrointestinal bleeding complicate encephalomyelitis in mice with delayed appearance of CNS IgM after intranasal alphavirus infection. [PDF]
J Gen Virol, 2018 Baxter VK +4 more
europepmc +2 more sources
A molecular understanding of alphavirus entry.
PLoS Pathogens, 2020 Alphaviruses cause severe human illnesses including persistent arthritis and fatal encephalitis. As alphavirus entry into target cells is the first step in infection, intensive research efforts have focused on elucidating aspects of this pathway ...
Autumn C Holmes +3 more
doaj +1 more source