Results 21 to 30 of about 3,257,979 (198)

Modulation of Monocyte-Driven Myositis in Alphavirus Infection Reveals a Role for CX₃CR1⁺ Macrophages in Tissue Repair. [PDF]

mBio, 2020
Arthritogenic alphaviruses cause debilitating inflammatory disease, and current therapies are restricted to palliative approaches. Here, we show that following monocyte-driven muscle inflammation, tissue recovery is associated with the accumulation of ...
Zaid A, Tharmarajah K, Mostafavi H, Freitas JR, Sheng KC, Foo SS, Chen W, Vider J, Liu X, West NP, Herrero LJ, Taylor A, Mackay LK, Getts DR, King NJC, Mahalingam S.   +15 more
europepmc   +2 more sources

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU)2016/429): Infection with salmonid alphavirus (SAV) [PDF]

EFSA Journal, 2023
Infection with salmonid alphavirus (SAV) was assessed according to the criteria of the Animal Health Law (AHL), in particular the criteria of Article 7 on disease profile and impacts, Article 5 on its eligibility to be listed, Annex IV for its ...
EFSA Panel on Animal Health and Welfare (AHAW), Søren Saxmose Nielsen, Julio Alvarez, Paolo Calistri, Elisabetta Canali, Julian Ashley Drewe, Bruno Garin‐Bastuji, José Luis Gonzales Rojas, Christian Gortázar, Mette S. Herskin, Virginie Michel, Miguel Ángel Miranda Chueca, Barbara Padalino, Helen Clare Roberts, Hans Spoolder, Karl Ståhl, Antonio Velarde, Arvo Viltrop, Christoph Winckler, James Bron, Niels Jorgen Olesen, Hilde Sindre, David Stone, Niccolò Vendramin, Sotiria Eleni Antoniou, Alessandro Broglia, Anna Eleonora Karagianni, Alexandra Papanikolaou, Dominique Joseph Bicout   +28 more
doaj   +2 more sources

Macromolecular Synthesis Shutoff Resistance by Myeloid Cells Is Critical to IRF7-Dependent Systemic Interferon Alpha/Beta Induction after Alphavirus Infection. [PDF]

J Virol, 2019
Most previous research exploring the interaction of alphaviruses with host cell antiviral responses has been conducted using fibroblast lineage cell lines.
Bhalla N, Gardner CL, Downs SN, Dunn M, Sun C, Klimstra WB.   +5 more
europepmc   +2 more sources

Lipid-Coated Mesoporous Silica Nanoparticles for the Delivery of the ML336 Antiviral to Inhibit Encephalitic Alphavirus Infection. [PDF]

Sci Rep, 2018
Venezuelan equine encephalitis virus (VEEV) poses a major public health risk due to its amenability for use as a bioterrorism agent and its severe health consequences in humans.
LaBauve AE, Rinker TE, Noureddine A, Serda RE, Howe JY, Sherman MB, Rasley A, Brinker CJ, Sasaki DY, Negrete OA.   +9 more
europepmc   +2 more sources

Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles

bioRxiv, 2021
RNA is a central molecule for RNA viruses, acting as mRNA and genome. However, the interactions that viral (v)RNA establishes with the host cell is only starting to be elucidated.
Kamel W, Ruscica V, Embarc-Buh A, de Laurent ZR, Garcia-Moreno M, Demyanenko Y, Madhusudhan M, Iselin L, Järvelin A, Hannan M, Kitano E, Moore S, Merits A, Davis I, Mohammed S, Castello A.   +15 more
europepmc   +2 more sources

Impact of Salmonid alphavirus infection in diploid and triploid Atlantic salmon (Salmo salar L.) fry. [PDF]

PLoS One, 2017
With increasing interest in the use of triploid salmon in commercial aquaculture, gaining an understanding of how economically important pathogens affect triploid stocks is important. To compare the susceptibility of diploid and triploid Atlantic salmon (
Herath TK, Ashby AJ, Jayasuriya NS, Bron JE, Taylor JF, Adams A, Richards RH, Weidmann M, Ferguson HW, Taggart JB, Migaud H, Fordyce MJ, Thompson KD.   +12 more
europepmc   +2 more sources

Granulocyte colony-stimulating factor protects against acute systemic alphavirus disease in a type I IFN-dependent manner [PDF]

Frontiers in Immunology
IntroductionArthritogenic alphaviruses, including chikungunya (CHIKV) and Mayaro virus (MAYV), cause disease characterized by fever, rash, and incapacitating joint pain.
Muddassar Hameed, Muddassar Hameed, Muddassar Hameed, Pallavi Rai, Pallavi Rai, Md Shakhawat Hossain, Md Shakhawat Hossain, Andrea Daamen, Peter E. Lipsky, James Weger-Lucarelli, James Weger-Lucarelli   +10 more
doaj   +2 more sources

The Intestinal Microbiome Restricts Alphavirus Infection and Dissemination through a Bile Acid-Type I IFN Signaling Axis. [PDF]

Cell, 2020
Winkler ES, Shrihari S, Hykes BL, Handley SA, Andhey PS, Huang YS, Swain A, Droit L, Chebrolu KK, Mack M, Vanlandingham DL, Thackray LB, Cella M, Colonna M, Artyomov MN, Stappenbeck TS, Diamond MS.   +16 more
europepmc   +2 more sources

An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis. [PDF]

Cell Host Microbe, 2020
Kim AS, Zimmerman O, Fox JM, Nelson CA, Basore K, Zhang R, Durnell L, Desai C, Bullock C, Deem SL, Oppenheimer J, Shapiro B, Wang T, Cherry S, Coyne CB, Handley SA, Landis MJ, Fremont DH, Diamond MS.   +18 more
europepmc   +2 more sources

Pathogenesis of experimental salmonid alphavirus infection in vivo: an ultrastructural insight. [PDF]

Vet Res, 2016
Salmonid alphavirus (SAV) is an enveloped, single-stranded, positive sense RNA virus belonging to the family Togaviridae. It causes economically devastating disease in cultured salmonids.
Herath TK, Herath TK, Ferguson HW, Weidmann MW, Bron JE, Thompson KD, Adams A, Muir KF, Richards RH.   +8 more
europepmc   +2 more sources