Results 111 to 120 of about 15,250 (221)

Inflammatory monocytes mediate control of acute alphavirus infection in mice

PLOS Pathogens, 2017
Chikungunya virus (CHIKV) and Ross River virus (RRV) are mosquito-transmitted alphaviruses that cause debilitating acute and chronic musculoskeletal disease. Monocytes are implicated in the pathogenesis of these infections; however, their specific roles are not well defined.
Kelsey C. Haist, Kristina S. Burrack, Bennett J. Davenport, Thomas E. Morrison   +3 more
openaire   +4 more sources

Serologic Surveillance for Orthoflaviviruses and Chikungunya Virus in Bats and Opossums in Chiapas, Mexico

Viruses
We performed serologic surveillance for selected arthropod-borne viruses (arboviruses) in bats and opossums in the Lacandona Rainforest, Chiapas, Mexico, in 2023–2024.
J. Manuel Aranda-Coello, Carlos Machain-Williams, Manuel Weber, Alma R. Dzul Rosado, Tyler R. Simpkins, Bradley J. Blitvich   +5 more
doaj   +1 more source

Proteomic Discovery of VEEV E2-Host Partner Interactions Identifies GRP78 Inhibitor HA15 as a Potential Therapeutic for Alphavirus Infections. [PDF]

Pathogens, 2021
Barrera MD, Barrera MD, Callahan V, Akhrymuk I, Bhalla N, Zhou W, Campbell C, Narayanan A, Kehn-Hall K.   +8 more
europepmc   +1 more source

The nonstructural protein NSs of Schmallenberg virus is targeted to the nucleolus and induces nucleolar disorganization [PDF]

, 2016
Schmallenberg virus (SBV) was discovered in Germany in late 2011 and then spread rapidly to many European countries. SBV is an orthobunyavirus that causes abortion and congenital abnormalities in ruminants.
Breard, Emmanuel, Caignard, Grégory, Cochet, Marielle, Coulpier, Muriel, Fablet, Aurore, Gouzil, Julie, Kundlacz, Cindy, Lara, Estelle, Palmarini, Massimo, Sailleau, Corinne, Varela, Mariana, Viarouge, Cyril, Vitour, Damien, Zientara, Stéphan   +13 more
core   +3 more sources

A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs [PDF]

, 2016
Chikungunya virus (CHIKV) is a globally spreading alphavirus against which there is no commercially available vaccine or therapy. Here we use a genome-wide siRNA screen to identify 156 proviral and 41 antiviral host factors affecting CHIKV replication ...
Berre, Stefano, Bracher, Franz, Braun, Peter, Couderc, Thérèsr, Gangneux, Nicolas, Karlas, Alexander, Karo-Astover, Liis, Klemm, Uwe, Lecuit, Marc, Merits, Andres, Meyer, Michael, Meyer, Thomas F., Raftery, Martin, Schönrich, Günther, Varjak, Margus, Weege, Friderike, Wurzlbauer, Anne   +16 more
core   +5 more sources

A Viral mRNA Motif at the 3′-Untranslated Region that Confers Translatability in a Cell-Specific Manner. Implications for Virus Evolution [PDF]

, 2016
Sindbis virus (SINV) mRNAs contain several motifs that participate in the regulation of their translation. We have discovered a motif at the 3′ untranslated region (UTR) of viral mRNAs, constituted by three repeated sequences, which is involved in the ...
Carrasco, Luis, Garcia-Moreno, Manuel, Sanz, Miguel Angel   +2 more
core   +2 more sources

Regulation of autophagy and mTOR during Semliki Forest virus infection [PDF]

, 2012
Semliki Forest virus (SFV) infection causes dramatic changes to the infected cell. For example, synthesis of most cellular proteins shuts off within 4 hours.
Eng, Kai
core   +1 more source

Insect response to alphavirus infection—Establishment of alphavirus persistence in insect cells involves inhibition of viral polyprotein cleavage

Virus Research, 2010
Alphavirus persistence in the insect vector is an essential element in the vector-host transmission cycle of the virus and provides a model to study the biochemical and molecular basis for virus-vector coexistence. The prototype alphavirus Sindbis (SV) establishes persistent infections in invertebrate cell cultures which are characterized by low levels
Usharani, Mudiganti, Raquel, Hernandez, Dennis T, Brown   +2 more
openaire   +2 more sources

TRIM32 inhibits Venezuelan equine encephalitis virus infection by targeting a late step in viral entry.

PLoS Pathogens
Alphaviruses are mosquito borne RNA viruses that are a reemerging public health threat. Alphaviruses have a broad host range, and can cause diverse disease outcomes like arthritis, and encephalitis.
Yifan Xie, Jie Cao, Shuyi Gan, Lingdong Xu, Dongjie Zhang, Suhong Qian, Feng Xu, Qiang Ding, John W Schoggins, Wenchun Fan   +9 more
doaj   +1 more source

Translational Control of Alphavirus–Host Interactions: Implications in Viral Evolution, Tropism and Antiviral Response

Viruses
Alphaviruses can replicate in arthropods and in many vertebrate species including humankind, but only in vertebrate cells do infections with these viruses result in a strong inhibition of host translation and transcription.
Iván Ventoso, Juan José Berlanga, René Toribio, Irene Díaz-López   +3 more
doaj   +1 more source