Results 251 to 260 of about 4,783,354 (355)

C9orf72-related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review. [PDF]

Front Mol Neurosci
Almalki S, Salama M, Taylor MJ, Ahmed Z, Tuxworth RI.   +4 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Non-canonical cell death in neurodegeneration: emerging mechanisms and therapeutic Frontiers. [PDF]

Apoptosis
Ercin N, Besli N, Beker M, Celik U.
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Gut Dysbiosis and Microbiota-Derived Metabolites in Neurodegenerative Diseases: Molecular and Biochemical Mechanisms Along the Gut-Brain Axis. [PDF]

Molecules
Czaj PV, Szewczyk-Golec K, Nuszkiewicz J, Woźniak A.   +3 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Excitotoxicity in amyotrophic lateral sclerosis: a key pathogenic mechanism. [PDF]

Brain Commun
Silva-Hucha S, Hernández RG, Baena-López D, Fernández de Sevilla ME, Paradas C, Morcuende S.   +5 more
europepmc   +1 more source

Proteasome inhibition by VR23 enhances autophagic clearance of FUS^P525L-mediated persistent stress granule in SH-SY5Y cells. [PDF]

Mol Brain
Kim SH, So JH, Kim YH, Kim HS, Park NY, Kim JB, Jo DS, Yeom E, Lee JA, Bae JE, Cho DH.   +10 more
europepmc   +1 more source

[Consensus statement of the Austrian Society for Rheumatology and Rehabilitation on the management of increased cardiovascular risk in rheumatoid arthritis, psoriatic arthritis and spondyloarthritis]. [PDF]

Wien Klin Wochenschr
Lindner B, Ausserwinkler M, Siess C, Ammerer K, Esposito M, Hermann J, Hintenberger R, Komposch M, Lanser L, Lechner-Radner H, Peter C, Rega-Kaun G, Reinhart-Mikocki D, Schedl S, Stögerer-Lanzenberger M, Thiel J, Niessner A.   +16 more
europepmc   +1 more source

FUS-related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review. [PDF]

Front Mol Neurosci
Almalki S, Salama M, Taylor MJ, Ahmed Z, Tuxworth RI.   +4 more
europepmc   +1 more source