Results 231 to 240 of about 112,092 (264)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1^G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection. [PDF]

Adv Sci (Weinh)
Wang F, Zhang KY, Zhu LJ, Li WJ, Wu Y, Gao X, Ma XR, Yin XH, Wu JB, Ye XK, Dong ZJ, Wang DX, Zhou Z, Wang SD, Han L, Jiang ZN, Zhao JW.   +16 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Current potential biomarkers for Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis: review of literature. [PDF]

Dialogues Clin Neurosci
Peng J, Fan T, Wang J, Deng Y, Xu R.
europepmc   +1 more source

Ferritin in ferroptosis: Implications for neurodegenerative diseases (Review). [PDF]

Int J Mol Med
Chen W, Tian H, Wei R, Chen X, Jia Y.
europepmc   +1 more source

Molecular Mechanisms of Herbicide Resistance in Rapeseed: Current Status and Future Prospects for Resistant Germplasm Development. [PDF]

Int J Mol Sci
Liu D, Yu S, Ji B, Peng Q, Gao J, Zhang J, Guo Y, Hu M.   +7 more
europepmc   +1 more source

RIG-I Mediated Neuron-Specific IFN Type 1 Signaling in FUS-ALS Induces Neurodegeneration and Offers New Biomarker-Driven Individualized Treatment Options for (FUS-)ALS. [PDF]

Adv Sci (Weinh)
Naumann M, Wierschin TM, Kretschmer S, Dash BP, Held A, Salzinger A, Peikert K, Karlek A, Glaß H, Großmann D, Günther R, Petri S, Rödiger A, Brenner D, Pan-Montojo F, Aronica E, Kipp M, Zimyanin V, Sterneckert J, Grehl T, Seebacher ND, Böckers TM, Catanese A, Wainger BJ, Oeckl P, Lee-Kirsch MA, Hermann A.   +26 more
europepmc   +1 more source

A comprehensive review of new pesticides developed between 2015 and 2025. [PDF]

J Pestic Sci
Umetsu N, Shirai Y.
europepmc   +1 more source

Neuronal Damage Induced by Gradual Oxidative Stress in iPSC-Derived Neurons: Implications for Ferroptosis Involvement and ALS Drug Evaluation. [PDF]

J Neurochem
Kobayashi H, Suzuki-Masuyama H, Tanabe H, Kato H, Endoh-Yamagami S.   +4 more
europepmc   +1 more source