Results 111 to 120 of about 382,720 (316)

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Hipocomplementemia en pacientes con enfermedad de Hodgkin Hypocomplementaemia in patients with Hodgkin disease

Revista Cubana de Hematología, Inmunología y Hemoterapia, 2003
The haemolytic activity of the classical and alternative pathways, of factors B and D, as well as of the levels of C1q, C3 and C4 was determined in the serum of 24 adult patients with Hodgkin disease at different clinical stages.
doaj  

Germline mutations in the alternative pathway of complement predispose to HELLP syndrome.

JCI Insight, 2018
BACKGROUND HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome is a severe variant of hypertensive disorders of pregnancy affecting approximately 1% of all pregnancies, and has significant maternal and fetal morbidity.
A. Vaught, Evan M. Braunstein, Jagar A. Jasem, Xuan Yuan, I. Makhlin, Solange N. Eloundou, Andrea C. Baines, Samuel A. Merrill, Shruti Chaturvedi, K. Blakemore, C. John Sperati, Robert A. Brodsky   +11 more
semanticscholar   +1 more source

An investigation into the feasibility and efficacy of stereotactic radiosurgery for 1–3 cm single brain lesions on the ring‐mounted Halcyon LINAC

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose An evaluation of the accuracy, safety, and efficiency of the Halcyon ring delivery system (RDS) for stereotactic radiosurgery (SRS) treatment to relatively small (1–3 cm) brain lesions. Methods After completing the extensive in‐house quality assurance checks including Winston–Lutz test and independent dose verification via MD Anderson ...
Kate Hazelwood, Shane McCarthy, Josh Misa, David Castelvetere, William St. Clair, Damodar Pokhrel   +5 more
wiley   +1 more source

Alternative Complement Pathway in Carotid Atherosclerosis: Low Plasma Properdin Levels Associate With Long‐Term Cardiovascular Mortality

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Complement activation may promote atherosclerosis. Yet, data on the to which extent complement, and more specifically the alternative complement pathway, is activated in patients with carotid atherosclerosis and related to adverse outcome in ...
Mieke C. Louwe, Chrysostomi Gialeli, Annika E. Michelsen, Sverre Holm, Andreas Edsfeldt, Karolina Skagen, Tove Lekva, Maria Belland Olsen, Vigdis Bjerkeli, Therese Schjørlien, Kristine Stø, Xiang Yi Kong, Tuva B. Dahl, Per H. Nilsson, Peter Libby, Pål Aukrust, Tom Eirik Mollnes, Thor Ueland, Mona Skjelland, Isabel Gonçalves, Bente Halvorsen   +20 more
doaj   +1 more source

Liraglutide for idiopathic intracranial hypertension: a real‐world propensity score‐matched study

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Idiopathic intracranial hypertension (IIH) is a neurological disorder predominantly affecting young women with obesity, characterized by elevated intracranial pressure. While current treatments include weight loss counseling, medical therapies, and surgical interventions, their limitations necessitate exploring novel therapeutic ...
Ahmed Y. Azzam, Muhammed Amir Essibayi, Dhrumil Vaishnav, Mohammed A. Azab, Mahmoud M. Morsy, Osman Elamin, Adam Elswedy, Oday Atallah, Hana J. Abukhadijah, Adam A. Dmytriw, Amanda Baker, Deepak Khatri, Neil Haranhalli, David J. Altschul   +13 more
wiley   +1 more source

Alternative Complement Pathway Inhibition by Lampalizumab: Analysis of Data From Chroma and Spectri Phase III Clinical Trials. [PDF]

Ophthalmol Sci, 2023
Edmonds R, Steffen V, Honigberg LA, Chang MC.   +3 more
europepmc   +1 more source

Self-Damage Caused by Dysregulation of the Complement Alternative Pathway: Relevance of the Factor H Protein Family

Frontiers in Immunology, 2018
The alternative pathway is a continuously active surveillance arm of the complement system, and it can also enhance complement activation initiated by the classical and the lectin pathways.
P. Sánchez-Corral, R. Pouw, M. López-Trascasa, M. Józsi   +3 more
semanticscholar   +1 more source

Unleashing the Power of Multiomics: Unraveling the Molecular Landscape of Peripheral Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Peripheral neuropathies (PNs) affect over 20 million individuals in the United States, manifesting as a wide range of sensory, motor, and autonomic nerve symptoms. While various conditions such as diabetes, metabolic disorders, trauma, autoimmune disease, and chemotherapy‐induced neurotoxicity have been linked to PN, approximately one‐third of
Julie Choi, Zitian Tang, Wendy Dong, Jenna Ulibarri, Elvisa Mehinovic, Simone Thomas, Ahmet Höke, Sheng Chih Jin   +7 more
wiley   +1 more source

Baicalin relieves complement alternative pathway activation-induced lung inflammation through inhibition of NF-κB pathway

BMC Complementary Medicine and Therapies
Introduction Acute lung injury (ALI) as one kind of acute pulmonary inflammatory disorder, manifests primarily as damage to alveolar epithelial cells and microvascular endothelial cells.
Jiao Li, Qi-Yun Zhang, Qing-Yu Lu, Qiao-Zhou Liu, Li Guo, Min Li, Qian-Yun Sun   +6 more
doaj   +1 more source