Renal FailureObjective The aim of this study was to investigate the potential importance of complement system activation, with particular emphasis on the complement alternative pathway (AP), in the pathogenesis of hypertensive renal damage.Methods Serum complement C3,
Zhongli Wang +8 more
doaj +1 more source
Qihuang Granule protects the retinal pigment epithelium from oxidative stress via regulation of the alternative complement pathway. [PDF]
BMC Complement Med Ther, 2023 Wang Y +6 more
europepmc +1 more source
Complement Activation in Semisolid Media: Insolubilization of Alternative Pathway Convertases in Agar Gels with C3 Nephritic Factor-Containing Sera [PDF]
, 1977 Mohammed A. Arnaout +3 more
openalex +1 more source
, 2012 The objective of this study was to evaluate the methodology to establish the hemolytic activity of alternative complement pathway as an indicator of the innate immunity in Brazilian fish pacu (Piaractus mesopotamicus), in addition to verifying the ...
J. D. Biller-Takahashi +5 more
semanticscholar +1 more source
The role of the alternative pathway of complement activation in glomerular diseases
Clinical and Experimental Medicine (Testo stampato), 2018 The complement system (CS) has recently been recognized as a bridge between innate and adaptive immunity that constitutes a very complex mechanism controlling the clearance of pathogens, cellular debris, and immune complexes.
Emilia Łukawska +2 more
semanticscholar +1 more source
Cerebello‐Prefrontal Connectivity Underlying Cognitive Dysfunction in Spinocerebellar Ataxia Type 2
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Spinocerebellar ataxia type 2 (SCA2) is a hereditary cerebellar degenerative disorder, with motor and cognitive symptoms. The constellation of cognitive symptoms due to cerebellar degeneration is named cerebellar cognitive affective syndrome (CCAS), which has increasingly been recognized to profoundly impact patients' quality of life;
Ami Kumar +7 more
wiley +1 more source
Alterations in the complement cascade in post-traumatic stress disorder
Allergy, Asthma & Clinical Immunology, 2010 Background In the present study we assessed the functional state of the major mediator of the immune response, the complement system, in post-traumatic stress disorder (PTSD).
Hovhannisyan Lilit P +3 more
doaj +1 more source
Targeting the Alternative Complement Pathway With Iptacopan to Treat IgA Nephropathy: Design and Rationale of the APPLAUSE-IgAN Study. [PDF]
Kidney Int Rep, 2023 Rizk DV +11 more
europepmc +1 more source
Opsonin-Independent Phagocytosis of Activators of the Alternative Complement Pathway by Human Monocytes [PDF]
, 1978 J K Czop +2 more
openalex +1 more source
Epitope Mapping of Anti‐Neurofascin 155 Antibody in a Large Cohort of Autoimmune Nodopathy Patients
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Autoimmune nodopathy (AN), a newly recognized disease entity, is an immune‐mediated polyneuropathy involving autoantibodies against cell adhesion molecules located in nodes of Ranvier and paranodal regions, such as neurofascin 186 (NF186) and neurofascin 155 (NF155). The present study aimed to identify the epitopes for autoantibodies
Amina A. Abdelhadi +6 more
wiley +1 more source