Results 131 to 140 of about 343,845 (337)

Chronic kidney disease enhances alternative pathway activity: a new paradigm

The Journal of Clinical Investigation
Reduced kidney function is associated with increased risk of cardiovascular disease in addition to kidney disease progression. Kidney disease is considered an inflammatory state, based on elevated levels of C-reactive protein and inflammatory cytokines ...
Diana I. Jalal, Joshua M. Thurman, Richard J.H. Smith   +2 more
doaj   +1 more source

Functional evaluation of rare variants in complement factor I using a minigene assay

Frontiers in Immunology
The regulatory serine protease, complement factor I (FI), in conjunction with one of its cofactors (FH, C4BP, MCP, or CR1), plays an essential role in controlling complement activity through inactivation of C3b and C4b.
Cobey J. H. Donelson, Nicolo Ghiringhelli Borsa, Amanda O. Taylor, Richard J. H. Smith, Yuzhou Zhang   +4 more
doaj   +1 more source

Qihuang Granule protects the retinal pigment epithelium from oxidative stress via regulation of the alternative complement pathway. [PDF]

BMC Complement Med Ther, 2023
Wang Y, Shen H, Pang L, Qiu B, Yuan Y, Guan X, Xiang X.   +6 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Targeting the Alternative Complement Pathway With Iptacopan to Treat IgA Nephropathy: Design and Rationale of the APPLAUSE-IgAN Study. [PDF]

Kidney Int Rep, 2023
Rizk DV, Rovin BH, Zhang H, Kashihara N, Maes B, Trimarchi H, Perkovic V, Meier M, Kollins D, Papachristofi O, Charney A, Barratt J.   +11 more
europepmc   +1 more source

Xenotransplanted Pig Sertoli Cells Inhibit Both the Alternative and Classical Pathways of Complement-Mediated Cell Lysis While Pig Islets Are Killed [PDF]

, 2016
Kandis Wright, Rachel Dziuk, Payal Mital, Gurvinder Kaur, Jannette M. Dufour   +4 more
openalex   +1 more source

60 Pattern recognition plays a role in the initiation of the alternative complement pathway

, 2023
Kevin Widmer, Jean-Luc Mary, Corinne Stucki, Elöd Körtvely   +3 more
openalex   +1 more source

Increased Alternative Complement Pathway Function Improves Survival During Critical Illness [PDF]

, 2020
William Bain, H. Li, Rick van der Geest, Sara Moore, Tolani F. Olonisakin, Brian Ahn, Kaveh Moghbeli, Rebecca DeSensi, Sarah F. Rapport, Melissa Saul, Mei Hulver, Z. Xiong, Rama K. Mallampalli, Prabir Ray, A.M. Morris, Yohei Doi, Y. Zhang, Georgios D. Kitsios, Bryan J. McVerry, Viviana P. Ferreira, Mehdi Nouraie, J. Lee   +21 more
openalex   +1 more source

Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin-Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H-Related Protein-5 (FHR5) Deposition

, 2017
Introduction IgA nephropathy (IgAN) is characterized by glomerular deposition of galactose-deficient IgA1 and complement proteins and leads to renal impairment.
Constantinou, N, Cook, HT, Hansen, AG, Lomax-Browne, HJ, Medjeral-Thomas, NR, Pickering, MC, Pusey, CD, Thiel, S, Troldborg, A, Willicombe, M   +9 more
core   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source