Results 211 to 220 of about 331,356 (244)
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Regulation of the alternative pathway of human complement by C1q
Molecular Immunology, 1987The interaction of C1q with C3b and its effect on C3b activities in the alternative pathway of complement (APC) have been studied. Purified C1q markedly inhibited C3b deposition on and lysis of rabbit erythrocytes by the isolated cytolytic APC. It also blocked formation of the C3 convertase, C3b, Bb as well as binding of Factors B and H to sheep ...
Zvi Fishelson, Hans J. Müller-Eberhard
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Alternative Modes and Pathways of Complement Activation
1977Complement (C) originally was detected by its ability to bring about cytolysis of antibody-sensitized bacteria and erythrocytes. Its name is derived from this ability to complement certain reactivities initiated by antibody. At least eleven С proteins, acting sequentially, are involved in mediating the usual antibody-initiated hemolysis. These proteins
Henry Gewurz, Thomas F. Lint
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Polyions regulate the alternative amplification pathway of complement
Immunopharmacology, 1983Polyanion has previously been shown to inhibit generation of amplification pathway convertase of complement and to inhibit H-mediated decay of this complex. Polycations, protamine sulfate, and poly-l-lysine (PLL) were examined in this study for direct effects on alternative amplification pathway mechanisms and for ability to regulate polyanion-induced ...
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Molecular Biology and Chemistry of the Alternative Pathway of Complement
1980Publisher Summary This chapter presents the proteins of the alternative pathway and their special properties as enzymes, enzyme substrates, and regulators. The participation with the classical pathway components, C5–C9, in membrane attack is considered.
Robert D. Schreiber +1 more
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The alternative complement pathway in chickens
Developmental & Comparative Immunology, 1983Leif Kongerslev +2 more
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Characterization of the alternative complement pathway of carp
Developmental & Comparative Immunology, 1988Koji Tanaka +3 more
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The cGAS–STING pathway as a therapeutic target in inflammatory diseases
Nature Reviews Immunology, 2021Alexiane Decout, Andrea Ablasser
exaly
The adenosine pathway in immuno-oncology
Nature Reviews Clinical Oncology, 2020Bertrand Allard +2 more
exaly
Lineage plasticity in cancer: a shared pathway of therapeutic resistance
Nature Reviews Clinical Oncology, 2020Helena A Yu +2 more
exaly