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The role of antibody in the activation of the alternative complement pathway
Seminars in Immunopathology, 1983The alternative complement pathway can be activated in the absence of specific antibody by the surface of certain cells and particles that provide a microenvironment in which the affinity of the regulatory protein H for surface-bound Cab is low. There is now abundant evidence that antibody can enhance activation.
K Frank Austen, Douglas T Fearon
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The complement alternative pathway and hemostasis
Immunological Reviews, 2022SummaryThe complement and hemostatic systems are complex systems, and both involve enzymatic cascades, regulators, and cell components—platelets, endothelial cells, and immune cells. The two systems are ancestrally related and are defense mechanisms that limit infection by pathogens and halt bleeding at the site of vascular injury.
Marina Noris, Miriam Galbusera
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The alternative pathway of complement
Springer Seminars in Immunopathology, 1984The alternative pathway of complement activation provides the host with a humoral component of the natural defense mechanisms against infectious agents. The six plasma proteins involved in recognition and activation perform a continuous surveillance function that does not require specific antibody to recognize potential pathogens.
M K, Pangburn, H J, Müller-Eberhard
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The Complement Alternative Pathway and Preeclampsia
Current Hypertension Reports, 2018Significant and intricate immune adaptations are essential for the establishment and maintenance of normal pregnancy. Preeclampsia is a morbid, potentially life-threatening disease for both mother and neonate that occurs uniquely in pregnancy, at least in part, due to maternal immune maladaptation.
Layan, Alrahmani +1 more
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The Alternative Pathway of Complement Activation
1976Publisher Summary This chapter presents the alternative pathway of complement activation. Two pathways for the recruitment of complement and its biological activities exist in plasma and serum. The first is termed as the “classical pathway,” which is triggered by contact of C1 with immune complexes containing antibodies of the immunoglobulin G (IgG ...
O, Götze, H J, Müller-Eberhard
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Abnormalities in the alternative pathway of complement in psoriasis
Clinical and Experimental Dermatology, 1982Summary Some of the immunologic aspects of psoriasis suggest that complement may be involved in the pathophysiology of that disease. The purpose of this work was to examine the complement system in more detail in 20 patients with psoriasis. Classical pathway determinations, RCH50 and factor B levels were normal or elevated.
W M, Marley +5 more
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The alternative pathway of complement and the thrombotic microangiopathies
Transfusion and Apheresis Science, 2016Thrombotic microangiopathies (TMA) are disorders defined by microangiopathic hemolytic anemia, non-immune thrombocytopenia and have multi-organ involvement including the kidneys, brain, gastrointestinal, respiratory tract and skin. Emerging evidence points to the central role of complement dysregulation in leading to microvascular endothelial injury ...
Chia Wei, Teoh +2 more
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Alternative pathway of complement in multiple myeloma
American Journal of Hematology, 1981AbstractThe alternative pathway of complement was studied in 16 newly diagnosed and 2 previously treated patients with multiple myeloma. Functional activity of this pathway was abnormal in 10 of these 18 patients (55%). These abnormalities correlated with depressed levels of alternative pathway components in 3 of 10 patients, but in the remaining 7, no
E H, Kraut, A L, Sagone
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[Alternative complement pathway].
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1984The alternative complement pathway comprises three component proteins C3, B, D and three regulatory proteins P, H and I. These plasma proteins represent the major humoral defense mechanism against infection in a non-immune host. The following topics are reviewed: biochemistry of the alternative pathway proteins; molecular mechanisms of activation and ...
M H, Jouvin, M, Kazatchkine
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