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[The alternative complement pathway].
Pathologie-biologie, 1984The alternative complement pathway comprises three component proteins C3, B, D and three regulatory proteins P, H and I. These plasma proteins represent the major humoral defense mechanism against infection in a non-immune host. The following topics are reviewed: biochemistry of the alternative pathway proteins; molecular mechanisms of activation and ...
M H, Jouvin, M, Kazatchkine
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Regulation of the alternative pathway of human complement by C1q
Molecular Immunology, 1987The interaction of C1q with C3b and its effect on C3b activities in the alternative pathway of complement (APC) have been studied. Purified C1q markedly inhibited C3b deposition on and lysis of rabbit erythrocytes by the isolated cytolytic APC. It also blocked formation of the C3 convertase, C3b, Bb as well as binding of Factors B and H to sheep ...
Z, Fishelson, H J, Müller-Eberhard
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Initiation of the alternative pathway of complement and the history of “tickover”
Immunological Reviews, 2022SummaryThe evolutionary history of complement suggests that the alternative pathway arose prior to the arrival of the classical and lectin pathways. In these pathways, target specificity is provided by antibodies and sugar specific lectins. While these efficient initiation systems dominate activation on most targets, the alternative pathway produces ...
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Molecular Biology and Chemistry of the Alternative Pathway of Complement
1980Publisher Summary This chapter presents the proteins of the alternative pathway and their special properties as enzymes, enzyme substrates, and regulators. The participation with the classical pathway components, C5–C9, in membrane attack is considered.
H J, Müller-Eberhard, R D, Schreiber
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A defect of the alternative pathway of complement.
Clinical and experimental immunology, 1977The sera of patients defective at opsonization for yeast phagocytosis fix haemolytic complement poorly following incubation with the alternative pathway complement activators, inulin and bacterial endotoxin. This suggests that the defect lies early in the alternative pathway of complement.
J F, Soothill, B A, Harvey
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The spectrum of complement alternative pathway‐mediated diseases
Immunological Reviews, 2008Summary: The complement system has once again come into prominence in the therapeutic development arena. The recent approval of an inhibitory monoclonal antibody, eculizumab, which is directed against complement component C5 for the disease paroxysmal nocturnal hemoglobinuria has provided the initial validation of this system as a therapeutic target ...
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Polyions regulate the alternative amplification pathway of complement
Immunopharmacology, 1983Polyanion has previously been shown to inhibit generation of amplification pathway convertase of complement and to inhibit H-mediated decay of this complex. Polycations, protamine sulfate, and poly-l-lysine (PLL) were examined in this study for direct effects on alternative amplification pathway mechanisms and for ability to regulate polyanion-induced ...
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Initiation of the alternative pathway of complement and the history of “tickover”
Immunological Reviews, 2023Michael K. Pangburn
exaly
Characterization of the alternative complement pathway of carp
Developmental & Comparative Immunology, 1988H, Matsuyama +3 more
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The Factor H protein family: The switchers of the complement alternative pathway
Immunological Reviews, 2023Laura Lucientes +1 more
exaly