The Factor H protein family: The switchers of the complement alternative pathway
Immunological Reviews, 2022 The factor H (FH) protein family is emerging as a complex network of proteins controlling the fate of the complement alternative pathway (AP) and dictating susceptibility to a wide range of diseases including infectious, inflammatory, autoimmune, and ...
Laura Lucientes-Continente +2 more
semanticscholar +1 more source
Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein [PDF]
, 2012 Human complement factor H-related protein (CFHR) 4 belongs to the factor H family of plasma glycoproteins that are composed of short consensus repeat (SCR) domains.
Hebecker, Mario, Józsi, Mihály
core +1 more source
Alternative complement pathway deregulation is correlated with dengue severity. [PDF]
PLoS ONE, 2009 BACKGROUND:The complement system, a key component that links the innate and adaptive immune responses, has three pathways: the classical, lectin, and alternative pathways. In the present study, we have analyzed the levels of various complement components
Eduardo J M Nascimento +6 more
doaj +1 more source
Complement in patients receiving maintenance hemodialysis: functional screening and quantitative analysis [PDF]
, 2010 Background The complement system is vital for innate immunity and is implicated in the pathogenesis of inflammatory diseases and the mechanism of host defense. Complement deficiencies occasionally cause life-threatening diseases.
Hiroyuki Inoshita +7 more
core +2 more sources
Complement Activation via the Lectin and Alternative Pathway in Patients With Severe COVID-19
Frontiers in Immunology, 2022 Complement plays an important role in the direct defense to pathogens, but can also activate immune cells and the release of pro-inflammatory cytokines. However, in critically ill patients with COVID-19 the immune system is inadequately activated leading
Janina Niederreiter +7 more
semanticscholar +1 more source
The Emerging Role of Complement Proteins as a Target for Therapy of IgA Nephropathy
Frontiers in Immunology, 2019 IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide and a common cause of end-stage renal disease. Evaluation of a kidney biopsy is necessary for diagnosis, with routine immunofluorescence microscopy revealing dominant ...
Dana V. Rizk +7 more
doaj +1 more source
Complement protein levels in plasma astrocyte-derived exosomes are abnormal in conversion from mild cognitive impairment to Alzheimer's disease dementia. [PDF]
, 2019 IntroductionLevels of complement proteins (CPs) in plasma astrocyte-derived exosomes (ADEs) that are abnormal in Alzheimer's disease (AD) have not been assessed in mild cognitive impairment (MCI).MethodsParticipants (n = 20 per group) had either MCI ...
Elahi, Fanny M +4 more
core +2 more sources
Blood protein adsorption onto chitosan [PDF]
, 2002 Chitosan was recently indicated to enhance osteogenesis, improve wound healing but to activate the coagulation and the complement systems. In the present study approximately 10nm thick chitosan film were prepared on aminopropyltriethoxysilane (APTES ...
Benesch, Johan, Tengvall, P.
core +1 more source
Diagnostics, 2023 Background: IgA vasculitis (IgAV) is the most common form of childhood vasculitis. A better understanding of its pathophysiology is required to identify new potential biomarkers and treatment targets.
Selcan Demir +7 more
doaj +1 more source
Anti-factor B autoantibody in dense deposit disease [PDF]
, 2010 Dense deposit disease (DDD), also known as membranoproliferative glomerulonephritis type II, is a rare kidney disorder that is associated with dysregulation of the alternative pathway of complement.
Józsi, Mihály +4 more
core +1 more source