Results 51 to 60 of about 331,356 (244)

Human complement factor H. Two factor H proteins are derived from alternatively spliced transcripts [PDF]

, 1991
The human complement factor H is an important component in the control of the alternative pathway of complement activation. We have previously shown that at least three factor H homologous mRNA species of 4.3 kb, 1.8 kb and 1.4 kb in length are ...
Alsenz, Alsenz, Aruffo, Chirgwin, Church, Conrad, Day, Feinberg, Fontaine, Kristensen, Laemmli, Maniatis, McAleer, Misasi, Pangburn, Ripoche, Schulz, Schulz, Schwaeble, Seed, Sim, Towbin, Whaley, Whaley   +23 more
core   +1 more source

Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]

, 2020
Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P., Leuvenink, Henri G. D., Nieuwenhuijs-Moeke, Gertrude J., Pischke, Soren E., Ploeg, Rutger J., Pol, Robert A., Sanders, Jan Stephan F., Struys, Michel   +7 more
core   +2 more sources

Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis. [PDF]

, 2016
Cholesterol crystals (CC) play an essential role in the formation of atherosclerotic plaques. CC activate the classical and the alternative complement pathways, but the role of the lectin pathway is unknown.
Genster, Ninette, Gál, Péter, Pilely, Katrine, Pál, Gábor, Rosbjerg, Anne   +4 more
core   +1 more source

Neutrophils from ANCA-associated vasculitis patients show an increased capacity to activate the complement system via the alternative pathway after ANCA stimulation.

PLoS ONE, 2019
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV), including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), are autoimmune conditions associated with small vessel inflammation.
Sophie Ohlsson, Lisa Holm, Christina Hansson, Susanne M Ohlsson, Lena Gunnarsson, Åsa Pettersson, Lillemor Skattum   +6 more
doaj   +1 more source

A novel assay that characterizes properdin function shows neutrophil-derived properdin has a distinct oligomeric distribution

Frontiers in Immunology, 2023
Properdin acts as an essential positive regulator of the alternative pathway of complement by stabilizing enzymatic convertases. Identical properdin monomers form head-to-tail associations of oligomers in a reported 20:54:26 ratio (most often described ...
Sara R. Moore, Smrithi S. Menon, Neeti S. Galwankar, Sadik A. Khuder, Michael K. Pangburn, Viviana P. Ferreira   +5 more
doaj   +1 more source

Activation of the alternative complement pathway by Histoplasma capsulatum [PDF]

Infection and Immunity, 1980
The present study was performed to determine whether Histoplasma capsulatum (yeast phase) is able to activate the alternative complement pathway. H. capsulatum yeasts were shown to consume C3 in C4-deficient guinea pig serum. Immunoelectrophoretic conversion of alternative pathway component factor B confirmed that C3 consumption was mediated by ...
J M Pepple, J A Winkelstein, W D Ratnoff
openaire   +3 more sources

Enhanced Osteogenesis of Adipose-Derived Stem Cells by Regulating Bone Morphogenetic Protein Signaling Antagonists and Agonists. [PDF]

, 2016
UnlabelledAlthough adipose-derived stem cells (ASCs) are an attractive cell source for bone tissue engineering, direct use of ASCs alone has had limited success in the treatment of large bone defects.
Aghaloo, Tara L, Bezouglaia, Olga, Cui, Zhong-Kai, Fan, Jiabing, Fartash, Armita, Guo, Mian, Im, Choong Sung, Kim, Soyon, Lee, Min, Patel, Nikhil, Wang, Cun-Yu, Wu, Benjamin M   +11 more
core   +2 more sources

Ecotin, a microbial inhibitor of serine proteases, blocks multiple complement dependent and independent microbicidal activities of human serum.

PLoS Pathogens, 2019
Ecotin is a serine protease inhibitor produced by hundreds of microbial species, including pathogens. Here we show, that ecotin orthologs from Escherichia coli, Yersinia pestis, Pseudomonas aeruginosa and Leishmania major are potent inhibitors of MASP-1 ...
Zoltán Attila Nagy, Dávid Szakács, Eszter Boros, Dávid Héja, Eszter Vígh, Noémi Sándor, Mihály Józsi, Gábor Oroszlán, József Dobó, Péter Gál, Gábor Pál   +10 more
doaj   +1 more source

FHR-1 binds to C-reactive protein and enhances rather than inhibits complement activation [PDF]

, 2017
Factor H (FH)-related protein 1 (FHR-1) is one of the five human factor H-related proteins, which share sequence and structural homology with the alternative pathway complement inhibitor FH.
Bánlaki, Zsófia, Cserhalmi, Marcell, Csincsi, Ádám, Józsi, Mihály, Kárpáti, Éva, Prohászka, Zoltán, Szabó, Z., Uzonyi, Barbara   +7 more
core   +1 more source

Activation of the Alternative Complement Pathway by Fonsecaea pedrosoi

Journal of Investigative Dermatology, 1984
Human sera were examined for evidence of complement activation by Fonsecaea pedrosoi. The serum that had been incubated with F. pedrosoi showed immunoelectrophoretic C3 conversion and generation of C5a, as measured by radioimmunoassay. C3 conversion and C5a generation did not occur in serum chelated with EDTA, or in serum heated to 56 degrees C for 30 ...
Hachiro Tagami, Kyoko Okohchi, H. Takematsu, Wakio Torinuki   +3 more
openaire   +3 more sources