Results 81 to 90 of about 135,678 (188)

Activation of the alternative pathway of complement by apoptotic Jurkat cells

, 1994
Jurkat T cells die of apoptosis upon exposure to anti-Fas mAb. Here we show that although the alternative complement pathway generally does not attack homologous cells, anti-Fas-induced apoptotic Jurkat T cells were attacked antibody-independently by the
Hitosi Nishimura, Shigeharu Nagasawa, Shoutaro Tsuji, Tsuji, Shoutaro, Nishimura, Hitosi, Hiroyuki Matsui, Matsui, Hiroyuki, Nagasawa, Shigeharu   +7 more
core   +1 more source

The Functional Amyloid Curli Protects Escherichia coli against Complement-Mediated Bactericidal Activity

Biomolecules, 2018
Escherichia coli strains may be beneficial or pathogenic. Many E. coli strains that cause human disease, especially those responsible for bacteremia and sepsis, express virulence factors that impart resistance to the complement system.
Steven G. Biesecker, Lauren K. Nicastro, R. Paul Wilson, Çağla Tükel   +3 more
doaj   +1 more source

Perioperative functional activity of the alternative pathway of complement in patients with colonic cancer

, 1999
OBJECTIVE: To investigate the functional capacity of the alternative pathway of complement in patients with cancer of the colon before, during, and after operation. DESIGN: Prospective study.
Qvist, N, Baatrup, G; id_orcid, Zimmermann-Nielsen, E   +2 more
core   +1 more source

Association between circulatory complement activation and hypertensive renal damage: a case–control study

Renal Failure
Objective The aim of this study was to investigate the potential importance of complement system activation, with particular emphasis on the complement alternative pathway (AP), in the pathogenesis of hypertensive renal damage.Methods Serum complement C3,
Zhongli Wang, Tingting Zhang, Xinyu Wang, Jianlong Zhai, Lili He, Sai Ma, Qingjuan Zuo, Guorui Zhang, Yifang Guo   +8 more
doaj   +1 more source

Genetic control of the alternative pathway of complement in humans and age-related macular degeneration

, 2010
Activation of the alternative pathway of complement is implicated in common neurodegenerative diseases including age-related macular degeneration (AMD).
Edwards, Albert O., Baratz, Keith H., Bailey, Kent R., Schmid-Kubista, Katharina E., Tosakulwong, Nirubol, Issa, Peter Charbel, Ryu, Euijung, Pollok-Kopp, Beatrix, Brown, William L., Scholl, Hendrik P. N., Oppermann, Martin, Hecker, Laura A.   +11 more
core   +1 more source

Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury [PDF]

, 2020
* Degeneration of photoreceptors is a primary cause of vision loss worldwide, making the underlying mechanisms surrounding photoreceptor cell death critical to developing new treatment strategies.
Keiko Kataoka, J Harry Sweigard, Ryoji Yanai, Demetrios Vavvas, John D Lambris, Eleftherios I Paschalis, Deeba Husain, Kaylee E Smith, Yoko Okonuki, Hidetaka Matsumoto, Joan W Miller, Leo A Kim, Alexandra Castillejos, Kip M Connor, Eiichi Hasegawa   +14 more
core  

Immunoglobulin M-enriched intravenous immunoglobulin inhibits classical pathway complement activation, but not bactericidal activity of human serum

, 2004
Acute or even hyperacute humoral graft rejection, mediated by classical pathway complement activation, occurs in allo- and xenotransplantation due to preformed anti-graft antibodies.
Aebi, Christoph, Mohacsi, Paul J, Thomas Laumonier, Christoph Aebi, Walpen, Alexander J, Robert Rieben, Alexander J. Walpen, Paul J. Mohacsi, Laumonier, Thomas, Rieben, Robert   +9 more
core   +1 more source

Baicalin relieves complement alternative pathway activation-induced lung inflammation through inhibition of NF-κB pathway

BMC Complementary Medicine and Therapies
Introduction Acute lung injury (ALI) as one kind of acute pulmonary inflammatory disorder, manifests primarily as damage to alveolar epithelial cells and microvascular endothelial cells.
Jiao Li, Qi-Yun Zhang, Qing-Yu Lu, Qiao-Zhou Liu, Li Guo, Min Li, Qian-Yun Sun   +6 more
doaj   +1 more source

Chronic kidney disease enhances alternative pathway activity: a new paradigm

The Journal of Clinical Investigation
Reduced kidney function is associated with increased risk of cardiovascular disease in addition to kidney disease progression. Kidney disease is considered an inflammatory state, based on elevated levels of C-reactive protein and inflammatory cytokines ...
Diana I. Jalal, Joshua M. Thurman, Richard J.H. Smith   +2 more
doaj   +1 more source

Functional evaluation of rare variants in complement factor I using a minigene assay

Frontiers in Immunology
The regulatory serine protease, complement factor I (FI), in conjunction with one of its cofactors (FH, C4BP, MCP, or CR1), plays an essential role in controlling complement activity through inactivation of C3b and C4b.
Cobey J. H. Donelson, Nicolo Ghiringhelli Borsa, Amanda O. Taylor, Richard J. H. Smith, Yuzhou Zhang   +4 more
doaj   +1 more source