Results 131 to 140 of about 2,301,526 (265)

Alternative methods for pharmacological research on the action mechanisms of natural products used in the treatment of type 2 diabetes: a systematic review. [PDF]

Front Pharmacol
Espinoza-Hernández FA, Martínez-Medina S, Mata-Torres G, Cabello-Hernández CA, Andrade-Cetto A.   +4 more
europepmc   +1 more source

Empirical assessment of alternative methods for identifying seasonality in observational healthcare data. [PDF]

BMC Med Res Methodol, 2022
Molinaro A, DeFalco F.
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

A cost-utility analysis for return-to-work interventions comparing alternative methods for handling missing health-related quality of life data. [PDF]

J Rehabil Med
Nguyen C, Burger EA, Aasdahl L, Morgante N, Fimland MS, Bjørnelv GMW.   +5 more
europepmc   +1 more source

Assessment of three alternative methods for bacterial disinfection of hatching eggs in comparison with conventional approach in commercial broiler hatcheries. [PDF]

PLoS One, 2023
Motola G, Hafez HM, Brüggemann-Schwarze S.   +2 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Alternative methods for analyzing cross-sectional studies of common outcomes: A guide for healthcare professionals. [PDF]

J Taibah Univ Med Sci
Aljawadi MH.
europepmc   +1 more source

Face-to-face and online teaching experience on experimental animals and alternative methods with nursing students: a research study. [PDF]

BMC Nurs, 2023
Garcia Sierra JF, Fernandez Martinez MN, Lopez Cadenas C, Diez Laiz R, Rodriguez Lago JM, Sahagun Prieto AM.   +5 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Global progress in competitive co-evolution: a systematic comparison of alternative methods. [PDF]

Front Robot AI
Nolfi S, Pagliuca P.
europepmc   +1 more source