Results 71 to 80 of about 2,258,983 (316)

Pectin Extraction From Orange Peel With Microwave-Assisted Extraction Method as an Alternative Material in Polymer Injection [PDF]

, 2023
Muhammad Khairul Afdhol, Catur Dian Setiawan, Tomi Erfando, Fatmawati Adam, Indra Dodo Saputra, Ridho Hendra Yoga Perdana   +5 more
openalex   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

An insight into carcinogenic activity and molecular mechanisms of Bis(2-ethylhexyl) phthalate

Frontiers in Toxicology
Di(ethylhexyl) phthalate (DEHP) is a ubiquitous environmental contaminant to which humans are exposed via multiple routes. Human health risk assessments for this substance have recently been updated, focusing on reproductive toxicity, including DEHP, in ...
Gelsomina Pillo, Gelsomina Pillo, Federico Aldrovandi, Federico Aldrovandi, Ada Mescoli, Giangabriele Maffei, Giangabriele Maffei, Maria Grazia Mascolo, Monica Vaccari, Annamaria Colacci, Annamaria Colacci   +10 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The Use of Different Hot Foam Doses for Weed Control

Agronomy, 2019
Thermal weed control technology plays an important role in managing weeds in synthetic herbicide-free systems, particularly in organic agriculture. The use of hot foam represents an evolution of the hot water weed control thermal method, modified by the ...
Luisa Martelloni, Christian Frasconi, Mino Sportelli, Marco Fontanelli, Michele Raffaelli, Andrea Peruzzi   +5 more
doaj   +1 more source

Use of nicarbazin, salinomycin and zinc oxide as alternative molting methods for commercial laying hens [PDF]

, 2014
Carla Heloísa de Faria Domingues, Sarah Sgavioli, Maria Fernanda Ferreira Menegucci Praes, Diana Maryuri Correa Castiblanco, P C A Marchizeli, Adriana Aparecida Pereira, Karina Ferreira Duarte, Otto Mack Junqueira   +7 more
openalex   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source