Results 111 to 120 of about 7,204,743 (394)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Corrigendum: Functional variant rs12614 in CFB confers a low risk of IgA nephropathy by attenuating complement alternative pathway activation in Han Chinese

Frontiers in Immunology, 2022
Dian-Chun Shi, Dian-Chun Shi, Dian-Chun Shi, Shao-Zhen Feng, Shao-Zhen Feng, Zhong Zhong, Zhong Zhong, Lu Cai, Lu Cai, Meng Wang, Meng Wang, Dong-Ying Fu, Dong-Ying Fu, Xue-Qing Yu, Xue-Qing Yu, Xue-Qing Yu, Ming Li, Ming Li, Ming Li   +18 more
doaj   +1 more source

Diastereoselective Synthesis of cis-2,6-Disubstituted Dihydropyrane Derivatives through a Competitive Silyl-Prins Cyclization versus Alternative Reaction Pathways [PDF]

, 2023
Laura Fernández-Peña, Enol López, Á. Sánchez-González, Asunción Barbero   +3 more
openalex   +1 more source

The ubiquitin E3/E4 ligase, UBE4A, fine-tunes protein ubiquitylation and accumulation at sites of DNA damage facilitating double-strand break repair [PDF]

, 2018
Double-strand breaks (DSBs) are critical DNA lesions that robustly activate the elaborate DNA damage response (DDR) network. We identified a critical player in DDR fine-tuning - the E3/E4 ubiquitin ligase, UBE4A.
Baranes Bachar, Keren, Huertas Sánchez, Pablo, Levy Barda, Adva, Oehler, Judith, Soria Bretones, Isabel   +4 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

NETosing neutrophils activate complement both on their own NETs and bacteria via alternative and non-alternative pathways

Frontiers in Immunology, 2016
Neutrophils deposit antimicrobial proteins such as myeloperoxidase and proteases on chromatin, which they release as neutrophil extracellular traps (NETs). Neutrophils also carry key components of the complement alternative pathway (AP) such as properdin
Joshua eYuen, Fred G. Pluthero, David N. Douda, Magdalena eRiedl, Ahmed eCherry, Marina eUlanova, Walter H.A. Kahr, Walter H.A. Kahr, Nades ePalaniyar, Christoph eLicht, Christoph eLicht   +10 more
doaj   +1 more source

Chemical Similarity Enrichment Analysis (ChemRICH) as alternative to biochemical pathway mapping for metabolomic datasets

Scientific Reports, 2017
Metabolomics answers a fundamental question in biology: How does metabolism respond to genetic, environmental or phenotypic perturbations? Combining several metabolomics assays can yield datasets for more than 800 structurally identified metabolites ...
D. Barupal, O. Fiehn
semanticscholar   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Editorial: Role of complement activation in kidney diseases

Frontiers in Medicine, 2023
Takashi Oda, Toshihiro Sawai
doaj   +1 more source

Roles of MASP-1 and MASP-3 in the development of retinal degeneration in a murine model of dry age-related macular degeneration

Frontiers in Immunology
Complement is activated through the three different pathways, which are the classical (CP), lectin (LP), and alternative pathways (AP). Complement activation functions to eliminate invading pathogens, whereas dysregulation of complement activation can ...
Tomoko Omori, Takeshi Machida, Yumi Ishida, Tetsuju Sekiryu, Hideharu Sekine   +4 more
doaj   +1 more source