Results 281 to 290 of about 7,204,743 (394)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

An Emotional Molecular Pathway in Pulmonary Hypertension–Alternative Complement System

, 2019
Gabriele Grünig, Nedim Durmuş
openalex   +1 more source

Human Monocytes Engage an Alternative Inflammasome Pathway.

Immunity, 2016
Moritz M. Gaidt, Thomas Ebert, Dhruv Chauhan, Tobias Schmidt, Jonathan L. Schmid-Burgk, F. Rapino, A. Robertson, M. Cooper, T. Graf, V. Hornung   +9 more
semanticscholar   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Metabolic regulation of leaf respiration and alternative pathway activity in response to phosphate supply [PDF]

, 2001
Miquel A. Gonzàlez‐Meler, Larry Giles, Richard B. Thomas, James N. Siedow   +3 more
openalex   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

A Complement Atlas identifies interleukin 6 dependent alternative pathway dysregulation as a key druggable feature of COVID-19

, 2023
Van Damme KF, Hoste L, Declercq J, Leeuw ED, Maes B, Martens L, Colman R, Browaeys R, Bosteels C, Verwaerde S, Vermeulen N, Lameire S, Debeuf N, Deckers J, Stordeur P, Guilliams M, Schetters ST, Haerynck F, Tavernier SJ, Lambrecht BN.   +19 more
europepmc   +1 more source

Exploring the Protein Glycosylation Pathways to Find New Therapeutic Alternatives

, 2015
Héctor M. Mora‐Montes
openalex   +1 more source

Modulation of UVB-induced Carcinogenesis by Activation of Alternative DNA Repair Pathways [PDF]

, 2018
Yan Sha, Vladimir L. Vartanian, Nichole Owen, Stephanie J. Mengden Koon, Marcus J. Calkins, Courtney S. Thompson, Zahra Mirafzali, Sara Doble Mir, Lisa E. Goldsmith, Huaping He, Chun Huai Luo, Scott M. Brown, Paul W. Doetsch, Andy Kaempf, Jeong Youn Lim, Amanda K. McCullough, R. Stephen Lloyd   +16 more
openalex   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source