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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective SCN1A‐related seizures first present as febrile seizures (FS). Definitive features emerge later, making early diagnosis challenging. We evaluated the diagnostic yield and clinical characteristics of pathogenic SCN1A variants in FS, and analyzed the effect of variant characteristics on clinical phenotypes required for early ...
Jia Wang +11 more
wiley +1 more source
In Vitro Modeling of Natural Killer Cell Cytotoxicity to Inform Personalized ALS Therapeutics
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Natural killer (NK) cells might contribute to motor neuron death in amyotrophic lateral sclerosis (ALS) through direct cytotoxicity, a process that could be inhibited with the FDA‐approved JAK/STAT pathway inhibitor, tofacitinib. This study aimed to verify that tofacitinib can suppress NK cell cytotoxicity, investigate if immune cell
Benjamin J. Murdock +8 more
wiley +1 more source
Distinct cross talk of IL-17 & TGF-β with the immature CD11c+ TRAF6(-/-) -null myeloid dendritic cell-derived osteoclast precursor (mDDOCp) may engage signaling toward an alternative pathway of osteoclastogenesis for arthritic bone loss in vivo. [PDF]
Immun Inflamm DisLiu YCG, Teng AY.
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The complement alternative pathway and hemostasis
Immunological Reviews, 2022The complement and hemostatic systems are complex systems, and both involve enzymatic cascades, regulators, and cell components—platelets, endothelial cells, and immune cells.
M. Noris, M. Galbusera
semanticscholar +3 more sources
Initiation of the alternative pathway of complement and the history of “tickover”
Immunological Reviews, 2022The evolutionary history of complement suggests that the alternative pathway arose prior to the arrival of the classical and lectin pathways. In these pathways, target specificity is provided by antibodies and sugar specific lectins.
M. K. Pangburn
semanticscholar +1 more source
The Complement Alternative Pathway and Preeclampsia
Current Hypertension Reports, 2018Significant and intricate immune adaptations are essential for the establishment and maintenance of normal pregnancy. Preeclampsia is a morbid, potentially life-threatening disease for both mother and neonate that occurs uniquely in pregnancy, at least in part, due to maternal immune maladaptation.
Layan Alrahmani, M. Willrich
semanticscholar +4 more sources
The alternative pathway of complement
Springer Seminars in Immunopathology, 1984The alternative pathway of complement activation provides the host with a humoral component of the natural defense mechanisms against infectious agents. The six plasma proteins involved in recognition and activation perform a continuous surveillance function that does not require specific antibody to recognize potential pathogens.
Michael K. Pangburn +1 more
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Alternative Pathway Evaluation [PDF]
Current Protocols in Immunology, 1994 AbstractThe alternative pathway of complement shares its terminal components (C3 and C5 through 9) with the classical pathway, but has several unique components, including factors D, B, and P (properdin). This unit presents methods for assaying total alternative pathway activity and the activity of factors B and D. Radial immunodiffusion (RID) can also
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The alternative antigen pathway
Immunology Today, 1989In this article, John Tew, Marie Kosco and Andras Szakal describe progress in deciphering a novel antigen pathway that represents an alternative to classical clearance by phagocytes. Upon booster immunization, immune complexes form rapidly and these complexes are handled not only by phagocytes but also by a series of non-phagocytic cells in a distinct ...
Andras K. Szakal, John G. Tew, M H Kosco
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