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FEBS Open Bio, EarlyView.CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama +7 more
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Distinct cross talk of IL-17 & TGF-β with the immature CD11c+ TRAF6(-/-) -null myeloid dendritic cell-derived osteoclast precursor (mDDOCp) may engage signaling toward an alternative pathway of osteoclastogenesis for arthritic bone loss in vivo. [PDF]
Immun Inflamm DisLiu YCG, Teng AY.
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The alternative pathway of complement
Springer Seminars in Immunopathology, 1984The alternative pathway of complement activation provides the host with a humoral component of the natural defense mechanisms against infectious agents. The six plasma proteins involved in recognition and activation perform a continuous surveillance function that does not require specific antibody to recognize potential pathogens.
Michael K. Pangburn +1 more
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Alternative Pathway Evaluation [PDF]
Current Protocols in Immunology, 1994 AbstractThe alternative pathway of complement shares its terminal components (C3 and C5 through 9) with the classical pathway, but has several unique components, including factors D, B, and P (properdin). This unit presents methods for assaying total alternative pathway activity and the activity of factors B and D. Radial immunodiffusion (RID) can also
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The alternative antigen pathway
Immunology Today, 1989In this article, John Tew, Marie Kosco and Andras Szakal describe progress in deciphering a novel antigen pathway that represents an alternative to classical clearance by phagocytes. Upon booster immunization, immune complexes form rapidly and these complexes are handled not only by phagocytes but also by a series of non-phagocytic cells in a distinct ...
Andras K. Szakal, John G. Tew, M H Kosco
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Alternative Complement Pathway in Schizophrenia [PDF]
Neurochemical Research, 2010 In the present study, we evaluated functional activity of the alternative pathway of complement in schizophrenia by measuring the alternative pathway hemolytic activity (AH50) of complement as well as hemolytic activity of the complement C3 component (C3H50) in the blood of patients with schizophrenia and healthy subjects.
Andranik Chavushyan +2 more
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An ‘Alternative’ Pathway of T Cell Activation [PDF]
International Archives of Allergy and Immunology, 1994 T cell receptor mediated signals in T cell activation determine the specificity, while costimulatory/accessory signals are responsible for functional results of the immune response. Given the large number of accessory receptors in the T cell membrane, there exists a potent instrument to fine-tune immune reactions.
Burkhart Schraven +2 more
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The complement alternative pathway and hemostasis
Immunological Reviews, 2022SummaryThe complement and hemostatic systems are complex systems, and both involve enzymatic cascades, regulators, and cell components—platelets, endothelial cells, and immune cells. The two systems are ancestrally related and are defense mechanisms that limit infection by pathogens and halt bleeding at the site of vascular injury.
Marina Noris, Miriam Galbusera
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Alternative pathway amplification and infections
Immunological Reviews, 2022SummaryThe alternative pathway (AP) is the phylogenetically oldest arm of the complement system and may have evolved to mark pathogens for elimination by phagocytes. Studies using purified AP proteins or AP‐specific serum showed that C3b amplification on bacteria commenced following a lag phase of about 5 min and was highly dependent on the ...
Jutamas Shaughnessy +3 more
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