Results 81 to 90 of about 7,204,743 (394)

High prevalence of the hotspot complement factor I p.Ile357Met pathogenic variant in Tunisian atypical hemolytic uremic syndrome patients: report of three new cases and review of the literature

Frontiers in Immunology
IntroductionAtypical Hemolytic Uremic Syndrome (aHUS) is the prototype of renal diseases secondary to dysregulation of the alternative complement pathway.
Asma Tajouri, Asma Tajouri, Asma Tajouri, Imen Ayadi, Imen Ayadi, Rimeh BenBrahim, Rimeh BenBrahim, Ikram Mami, Abir Boussetta, Hend Jlajla, Hend Jlajla, Yousr Zerzeri, Haifa Arbi Sassi, Jamila Ben Sassi, Hela Sahli, Lilia Laadhar, Lilia Laadhar, Tahar Gargah, Mohamed Karim Zouaghi, Maryam Kallel Sellami, Maryam Kallel Sellami   +20 more
doaj   +1 more source

Complement-coagulation cross-talk: a potential mediator of the physiological activation of complement by low pH

Frontiers in Immunology, 2015
The complement system is a major constituent of the innate immune system. It not only bridges innate and adaptive arms of the immune system but also links the immune system with the coagulation system.
Hany Ibrahim Kenawy, Ismet eBoral, Alan eBevington   +2 more
doaj   +1 more source

Alternative Pathway Is Involved in Hydrogen Peroxide-Enhanced Cadmium Tolerance in Hulless Barley Roots

Plants, 2021
Hulless barley, grown in the Qinghai Tibet Plateau, has a wide range of environmental stress tolerance. Alternative pathway (AP) and hydrogen peroxide (H2O2) are involved in enhancing plant tolerance to environmental stresses.
Li He, Xiaomin Wang, Xiaofan Na, Ruijun Feng, Qiang He, Shengwang Wang, Cuifang Liang, Lili Yan, Libin Zhou, Yurong Bi   +9 more
doaj   +1 more source

Identification and characterization of an inhibitory fibroblast growth factor receptor 2 (FGFR2) molecule, up-regulated in an Apert Syndrome mouse model [PDF]

, 2011
AS (Apert syndrome) is a congenital disease composed of skeletal, visceral and neural abnormalities, caused by dominant-acting mutations in FGFR2 [FGF (fibroblast growth factor) receptor 2].
Anderson, Beenken, Bochukova, Burgar, Celli, Cohen, De Moerlooze, Duan, Duchesne, Ezzat, Fairbanks, Hajihosseini, Hajihosseini, Hajihosseini, Hajihosseini, Hajihosseini, Hanneken, Ibrahimi, Jang, Jang, Jang, John K. Heath, Jones, Kawano, Klein, Kuro-o, Lee M. Wheldon, Lewis, Maquat, McKeehan, Mendell, Meyers, Miki, Mohammad K. Hajihosseini, Muhlemann, Naila Khodabukus, Naski, Nelson, Oldridge, Peters, Polanska, Ricol, Saito, Sekine, Slaney, Smith, Susannah J. Patey, Takaishi, Tanimoto, Terada, Terence G. Smith, Tsang, Tsukuno, Werner, Wheldon, Wilkie, Yamaguchi, Zhang   +57 more
core   +3 more sources

The alternative complement pathway revisited [PDF]

Journal of Cellular and Molecular Medicine, 2008
Introduction Methods to study and modify the alternative pathway Influence of AP amplification on the effect of specific activation of the other initial pathways Properdin Influence of AP in deficiency states Complement in sepsis Concluding remarks AbstractAlternative pathway amplification plays a major role for the final effect of initial specific ...
Harboe, Morten, Mollnes, Tom Eirik
openaire   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Differential modulation of SARS-CoV-2 infection by complement factor H and properdin

Frontiers in Immunology
IntroductionAn unbalanced immune response and excessive inflammation are the major hallmarks of severe SARS-CoV-2 infection, which can result in multiorgan failure and death. The dysregulation of the complement system has been shown in various studies as
Uday Kishore, Uday Kishore, Praveen M. Varghese, Chandan Kumar, Susan Idicula-Thomas, Martin Mayora Neto, Anthony G. Tsolaki, Pretty Ponnachan, Pretty Ponnachan, Khaled Masmoudi, Basel Al-Ramadi, Basel Al-Ramadi, Manu Vatish, Taruna Madan, Taruna Madan, Nigel Temperton, Nazar Beirag, Nazar Beirag   +17 more
doaj   +1 more source

Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Abdul-Aziz, M, Kishore, U, Kouser, L, Nayak, A, Sim, RB, Stover, CM   +5 more
core   +1 more source

An alternative cytokinin biosynthesis pathway [PDF]

Proceedings of the National Academy of Sciences, 2000
Studies of de novo cytokinin biosynthesis in isopentenyltransferase ( ipt )-transformed Arabidopsis thaliana , involving in vivo deuterium labeling and mass spectrometry, showed that the biosynthetic rate of zeatinriboside-5′-monophosphate was
C, Astot, K, Dolezal, A, Nordström, Q, Wang, T, Kunkel, T, Moritz, N H, Chua, G, Sandberg   +7 more
openaire   +2 more sources

Serrated Polyps and Their Alternative Pathway to the Colorectal Cancer: A Systematic Review

Gastroenterology Research and Practice, 2015
Colorectal cancer (CRC) is the third most frequently diagnosed cancer in the world. For a long time, only one pathway of colorectal carcinogenesis was known. In recent years, a new “alternative” pathway through serrated adenoma was described. Recent meta-
Łukasz Szylberg, Marlena Janiczek, A. Popiel, A. Marszałek   +3 more
semanticscholar   +1 more source