Results 131 to 140 of about 51,497 (273)

Optimised Ribosome Profiling Reveals New Insights Into Translational Regulation in Synchronised Chlamydomonas reinhardtii Cultures

Plant, Cell &Environment, Volume 48, Issue 9, Page 6982-7000, September 2025.
ABSTRACT Deep sequencing of ribosome footprints, also known as ribosome profiling (Ribo‐seq), enables the quantification of mRNA translation and a comprehensive view of the translatome landscape. Here, we report an optimised Ribo‐seq protocol and analysis pipeline for the model green alga, Chlamydomonas reinhardtiii (Chlamydomonas).
Yen‐Ling Lin, Eva Yuhua Kuo, Shih‐Yi Wang, Chih‐Chi Lee, Su‐Chiung Fang   +4 more
wiley   +1 more source

U1‐70K and U1A and tau pathogenesis in demented and non‐demented individuals with Down syndrome

Alzheimer's &Dementia, Volume 21, Issue 8, August 2025.
Abstract INTRODUCTION Splicing protein mislocalization is associated with tau pathogenesis, but its role in Down syndrome (DS) is under‐investigated. METHODS Spliceosome associations with tau and plaque pathology were examined in frontal cortex from DS with dementia (DSD+) and without dementia (DSD−) using quantitative immunoblotting and ...
Sylvia E. Perez, Jennifer C. Miguel, Muhammad Nadeem, Michael Malek‐Ahmadi, Chadwick M. Hales, Elizabeth Head, Elliott J. Mufson   +6 more
wiley   +1 more source

Altered polyadenylation site usage in SERPINA1 3’UTR in response to cellular stress affects A1AT protein expression

Scientific Reports
Alternative polyadenylation results in different 3’ isoforms of messenger RNA (mRNA) transcripts. Alternative polyadenylation in the 3’ untranslated region (3’UTR) can alter RNA localization, stability and translational efficiency.
F. N. U. Jiamutai, Abigail Hatfield, Austin Herbert, Debarati Majumdar, Vijay Shankar, Lela Lackey   +5 more
doaj   +1 more source

Mitochondrial genetics of alloplasmic male-sterile Brassica napus lines [PDF]

, 2005
Reliable and economical production of hybrid (F1) varieties requires efficient means to control pollination. The predominant system for pollination control of most field crops today is cytoplasmic male sterility (CMS).
Leino, Matti
core  

Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites [PDF]

, 1999
Lin Zhang, Lan Ge, Satish Parimoo, Kurt S. Stenn, Stephen M. Prouty   +4 more
openalex   +1 more source

Mitogenomic Profiling of Cyclocheilichthys repasson (Cypriniformes: Cyprinidae) and Its Phylogenetic Placement Within the Clade “Poropuntiinae”

Ecology and Evolution, Volume 15, Issue 8, August 2025.
In this study, we report the first complete mitochondrial genome of Cyclocheilichthys repasson from its native range in Indonesia. We characterize its genetic features in detail and elucidate its phylogenetic placement and matrilineal evolutionary history within the Clade “Poropuntiinae” in the family Cyprinidae.
Ayu Fitri Izaki, Sarifah Aini, Angkasa Putra, Hey‐Eun Kang, Ah Ran Kim, Soo Rin Lee, Mugi Mulyono, Muhammad Hilman Fu'adil Amin, Hyun‐Woo Kim, Shantanu Kundu   +9 more
wiley   +1 more source

Upregulation of Functional Kv11.1 Isoform Expression by Inhibition of Intronic Polyadenylation with Antisense Morpholino Oligonucleotides

, 2012
The KCNH2 gene encodes the Kv11.1 potassium channel that conducts the rapidly activating delayed rectifier current in the heart. KCNH2 pre-mRNA undergoes alternative processing; intron 9 splicing leads to the formation of a functional, full-length Kv11 ...
Gong, Qiuming, Stump, Matthew R., Zhou, Zhengfeng   +2 more
core   +2 more sources

RNA Binding Protein CELF2 Regulates Signal-Induced Alternative Polyadenylation by Competing with Enhancers of the Polyadenylation Machinery

Cell Reports, 2019
Summary: The 3′ UTR (UTR) of human mRNAs plays a critical role in controlling protein expression and function. Importantly, 3′ UTRs of human messages are not invariant for each gene but rather are shaped by alternative polyadenylation (APA) in a cell ...
Rakesh Chatrikhi, Michael J. Mallory, Matthew R. Gazzara, Laura M. Agosto, Wandi S. Zhu, Adam J. Litterman, K. Mark Ansel, Kristen W. Lynch   +7 more
doaj  

Impact of Acute Endurance Exercise on Alternative Splicing in Skeletal Muscle

FASEB BioAdvances, Volume 7, Issue 8, August 2025.
Current model on the effects of acute endurance exercise on the AS regulatory mechanism with key trans‐factors/RBPs (e.g., hnRNP‐A1, ‐A3, and TIA1). ABSTRACT Alternative splicing (AS) is a highly conserved posttranscriptional mechanism, generating mRNA variants to diversify the proteome.
Alexander Ahn, Jeongjin J. Kim, Aaron L. Slusher, Jeffrey Y. Ying, Eric Y. Zhang, Andrew T. Ludlow   +5 more
wiley   +1 more source

CFIm25 and alternative polyadenylation: Conflicting roles in cancer

Cancer Letters, 2019
Alternative polyadenylation (APA) is now widely recognized to regulate gene expression. APA is an RNA-processing mechanism that generates distinct 3' termini on mRNAs, producing mRNA isoforms. Different factors influence the initiation and development of this process.
Mohammad Hassan Jafari Najaf Abadi, Michael R. Hamblin, Roxana Sahebnasagh, Hamed Mirzaei, Rana Shafabakhsh, Hamid Reza Mirzaei, Zatollah Asemi   +6 more
openaire   +4 more sources