Results 11 to 20 of about 3,593,907 (372)
Pharmacology of Modulators of Alternative Splicing [PDF]
Pharmacological Reviews, 2017 More than 95% of genes in the human genome are alternatively spliced to form multiple transcripts, often encoding proteins with differing or opposing function. The control of alternative splicing is now being elucidated, and with this comes the opportunity to develop modulators of alternative splicing that can control cellular function.
Bates, DO +4 more
openaire +11 more sources
A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development [PDF]
, 2018 While gene expression dynamics have been extensively cataloged during hematopoietic differentiation in the adult, less is known about transcriptome diversity of human hematopoietic stem cells (HSCs) during development. To characterize transcriptional and
Marcella Cesana +20 more
openalex +4 more sources
Nature Communications, 2022 Revealing how the mind represents information is a longstanding goal of cognitive science. However, there is currently no framework for reconstructing the broad range of mental representations that humans possess.
Joseph L. Watson +27 more
semanticscholar +1 more source
Alternative splicing during fruit development among fleshy fruits
BMC Genomics, 2021 Background Alternative splicing (AS) is an important mechanism of posttranscriptional modification and dynamically regulates multiple physiological processes in plants, including fruit ripening.
Xiaomin Yan +4 more
doaj +1 more source
Alternative splicing: Human disease and quantitative analysis from high-throughput sequencing
Computational and Structural Biotechnology Journal, 2021 Alternative splicing contributes to the majority of protein diversity in higher eukaryotes by allowing one gene to generate multiple distinct protein isoforms. It adds another regulation layer of gene expression.
Wei Jiang, Liang Chen
doaj +1 more source
Chromatin and Alternative Splicing [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2010 Alternative splicing affects more than 90% of human genes. Coupling between transcription and splicing has become crucial in the complex network underlying alternative splicing regulation. Because chromatin is the real template for nuclear transcription, changes in its structure, but also in the "reading" and "writing" of the histone code, could ...
Alló, M. +7 more
openaire +4 more sources
Alternative splicing and cancer: a systematic review
Signal Transduction and Targeted Therapy, 2021 The abnormal regulation of alternative splicing is usually accompanied by the occurrence and development of tumors, which would produce multiple different isoforms and diversify protein expression. The aim of the present study was to conduct a systematic
Y. Zhang, Jinjun Qian, C. Gu, Ye Yang
semanticscholar +1 more source
Rice, 2021 Alternative splicing is a widespread phenomenon, which generates multiple isoforms of the gene product. Reproductive development is the key process for crop production. Although numerous forms of alternative splicing have been identified in model plants,
Haoxuan Li +5 more
doaj +1 more source
Alternative Splice in Alternative Lice [PDF]
Molecular Biology and Evolution, 2015 Genomic and transcriptomics analyses have revealed human head and body lice to be almost genetically identical; although con-specific, they nevertheless occupy distinct ecological niches and have differing feeding patterns. Most importantly, while head lice are not known to be vector competent, body lice can transmit three serious bacterial diseases ...
Tovar-Corona, Jaime M. +8 more
openaire +2 more sources
Alternative Splicing and Isoforms: From Mechanisms to Diseases
Genes, 2022 Alternative splicing of pre-mRNA is a key mechanism for increasing the complexity of proteins in humans, causing a diversity of expression of transcriptomes and proteomes in a tissue-specific manner.
Qi Liu, Leiming Fang, Chengjun Wu
semanticscholar +1 more source