Results 11 to 20 of about 326,335 (355)

Alternative Splicing in Apicomplexan Parasites [PDF]

mBio, 2019
Alternative splicing is a widespread, essential, and complex component of gene regulation. Apicomplexan parasites have long been recognized to produce alternatively spliced transcripts for some genes and can produce multiple protein products that are ...
Lee M. Yeoh, V. Vern Lee, Geoffrey I. McFadden, Stuart A. Ralph   +3 more
doaj   +4 more sources

Pharmacology of modulators of alternative splicing [PDF]

Pharmacological Reviews, 2016
More than 95% of genes in the human genome are alternatively spliced to form multiple transcripts, often encoding proteins with differing or opposing function.
Bates, DO, Donaldson, LF, Garland, CJ, Morris, JC, Oltean, S   +4 more
core   +11 more sources

Alternative Splicing and Cancer

Journal of Nucleic Acids, 2012
Alternative splicing of premessenger RNAs is a key step in the gene expression process, which allows the synthesis of different products from the same gene and contributes to increase the complexity of the proteome coded by a limited number of genes. Specialized high-throughput technologies (RNA-Seq, splicing-sensitive microarrays) aiming at analyzing ...
Didier Auboeuf, Maria Carmo-Fonseca, Juan Valcarcel, Giuseppe Biamonti   +3 more
doaj   +4 more sources

Alternative Splice in Alternative Lice [PDF]

Molecular Biology and Evolution, 2015
Genomic and transcriptomics analyses have revealed human head and body lice to be almost genetically identical; although con-specific, they nevertheless occupy distinct ecological niches and have differing feeding patterns. Most importantly, while head lice are not known to be vector competent, body lice can transmit three serious bacterial diseases ...
John M. Clark, Atahualpa Castillo-Morales, Araxi O. Urrutia, Stuart E. Reynolds, Jaime M. Tovar-Corona, Brett P. Olds, Barry R. Pittendrigh, Edward J. Feil, Lu Chen   +8 more
openaire   +3 more sources

Chromatin and Alternative Splicing [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2010
Alternative splicing affects more than 90% of human genes. Coupling between transcription and splicing has become crucial in the complex network underlying alternative splicing regulation. Because chromatin is the real template for nuclear transcription, changes in its structure, but also in the "reading" and "writing" of the histone code, could ...
Alló, M., Schor, I.E., Muñoz, M.J., De La Mata, M., Agirre, E., Valcárcel, J., Eyras, E., Kornblihtt, A.R.   +7 more
openaire   +5 more sources

Alternative Splicing in CKD [PDF]

Journal of the American Society of Nephrology, 2016
Alternative splicing (AS) has emerged in the postgenomic era as one of the main drivers of proteome diversity, with ≥94% of multiexon genes alternatively spliced in humans. AS is therefore one of the main control mechanisms for cell phenotype, and is a process deregulated in disease.
Stevens, Megan, Oltean, Sebastian
openaire   +4 more sources

The Expanding Landscape of Alternative Splicing Variation in Human Populations. [PDF]

, 2018
Alternative splicing is a tightly regulated biological process by which the number of gene products for any given gene can be greatly expanded. Genomic variants in splicing regulatory sequences can disrupt splicing and cause disease.
Lin, Lan, Pan, Zhicheng, Park, Eddie, Xing, Yi, Zhang, Zijun   +4 more
core   +1 more source

The neurogenetics of alternative splicing [PDF]

Nature Reviews Neuroscience, 2016
Alternative precursor-mRNA splicing is a key mechanism for regulating gene expression in mammals and is controlled by specialized RNA-binding proteins. The misregulation of splicing is implicated in multiple neurological disorders. We describe recent mouse genetic studies of alternative splicing that reveal its critical role in both neuronal ...
Celine K. Vuong, Sika Zheng, Douglas L. Black   +2 more
openaire   +3 more sources

Betacoronavirus-specific alternate splicing [PDF]

Genomics, 2021
AbstractViruses can subvert a number of cellular processes in order to block innate antiviral responses, and many viruses interact with cellular splicing machinery. SARS-CoV-2 infection was shown to suppress global mRNA splicing, and at least 10 SARS-CoV-2 proteins bind specifically to one or more human RNAs.
Deanne Taylor, Deanne Taylor, Daniel Butler, Afshin Beheshti, Afshin Beheshti, Levy S, Jonathan Foox, Christopher Mozsary, Karlebach G, Mason C, Peter N. Robinson, Eve Syrkin Wurtele, Amanda M. Saravia-Butler, Bruce J. Aronow, Baylin Sj, Cem Meydan   +15 more
openaire   +4 more sources

SIRT1 Involved in the Regulation of Alternative Splicing Affects the DNA Damage Response in Neural Stem Cells

Cellular Physiology and Biochemistry, 2018
Background/Aims: Alternative splicing and DNA damage exhibit cross-regulation, with not only DNA damage inducing changes in alternative splicing, but alternative splicing itself possibly modulating the DNA damage response (DDR).
Guangming Wang, Fangce Wang, Jie Ren, Yue Qiu, Wenjun Zhang, Shane Gao, Danjing Yang, Zhigang Wang, Aibin Liang, Zhengliang Gao, Jun Xu   +10 more
doaj   +1 more source