Results 11 to 20 of about 411,790 (378)

Quantifying alternative splicing from paired-end RNA-sequencing data [PDF]

Annals of Applied Statistics 2014, Vol. 8, No. 1, 309-330, 2014
RNA-sequencing has revolutionized biomedical research and, in particular, our ability to study gene alternative splicing. The problem has important implications for human health, as alternative splicing may be involved in malfunctions at the cellular level and multiple diseases.
Attolini, Camille Stephan-Otto, Kroiss, Manuel, Rossell, David, Stöcker, Almond   +3 more
arxiv   +3 more sources

Pharmacology of Modulators of Alternative Splicing [PDF]

Pharmacological Reviews, 2017
More than 95% of genes in the human genome are alternatively spliced to form multiple transcripts, often encoding proteins with differing or opposing function. The control of alternative splicing is now being elucidated, and with this comes the opportunity to develop modulators of alternative splicing that can control cellular function.
Bates, DO, Morris, JC, Oltean, S, Donaldson, LF, Garland, CJ   +4 more
openaire   +12 more sources

A polynomial delay algorithm for the enumeration of bubbles with length constraints in directed graphs and its application to the detection of alternative splicing in RNA-seq data [PDF]

arXiv, 2013
We present a new algorithm for enumerating bubbles with length constraints in directed graphs. This problem arises in transcriptomics, where the question is to identify all alternative splicing events present in a sample of mRNAs sequenced by RNA-seq.
Lacroix, Vincent, Sacomoto, Gustavo, Sagot, Marie-France   +2 more
arxiv   +3 more sources

Global Survey of Alternative Splicing in Rice by Direct RNA Sequencing During Reproductive Development: Landscape and Genetic Regulation

Rice, 2021
Alternative splicing is a widespread phenomenon, which generates multiple isoforms of the gene product. Reproductive development is the key process for crop production. Although numerous forms of alternative splicing have been identified in model plants,
Haoxuan Li, Aixuan Li, Wei Shen, Nenghui Ye, Guanqun Wang, Jianhua Zhang   +5 more
doaj   +1 more source

Chromatin and Alternative Splicing [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2010
Alternative splicing affects more than 90% of human genes. Coupling between transcription and splicing has become crucial in the complex network underlying alternative splicing regulation. Because chromatin is the real template for nuclear transcription, changes in its structure, but also in the "reading" and "writing" of the histone code, could ...
Alló, M., Schor, I.E., Muñoz, M.J., De La Mata, M., Agirre, E., Valcárcel, J., Eyras, E., Kornblihtt, A.R.   +7 more
openaire   +5 more sources

Alternative splicing regulation during C. elegans development: splicing factors as regulated targets. [PDF]

PLoS Genetics, 2008
Alternative splicing generates protein diversity and allows for post-transcriptional gene regulation. Estimates suggest that 10% of the genes in Caenorhabditis elegans undergo alternative splicing. We constructed a splicing-sensitive microarray to detect
Sergio Barberan-Soler, Alan M Zahler
doaj   +1 more source

Alternative Splicing in CKD [PDF]

Journal of the American Society of Nephrology, 2016
Alternative splicing (AS) has emerged in the postgenomic era as one of the main drivers of proteome diversity, with ≥94% of multiexon genes alternatively spliced in humans. AS is therefore one of the main control mechanisms for cell phenotype, and is a process deregulated in disease.
Stevens, Megan, Oltean, Sebastian
openaire   +4 more sources

Betacoronavirus-specific alternate splicing [PDF]

Genomics, 2021
AbstractViruses can subvert a number of cellular processes in order to block innate antiviral responses, and many viruses interact with cellular splicing machinery. SARS-CoV-2 infection was shown to suppress global mRNA splicing, and at least 10 SARS-CoV-2 proteins bind specifically to one or more human RNAs.
Deanne Taylor, Deanne Taylor, Daniel Butler, Afshin Beheshti, Afshin Beheshti, Levy S, Jonathan Foox, Christopher Mozsary, Karlebach G, Mason C, Peter N. Robinson, Eve Syrkin Wurtele, Amanda M. Saravia-Butler, Bruce J. Aronow, Baylin Sj, Cem Meydan   +15 more
openaire   +4 more sources

Alternative splicing and disease [PDF]

RNA Biology, 2008
Splicing is a molecular mechanism, by which introns are removed from an mRNA precursor and exons are ligated to form a mature mRNA. Mutations that cause defects in the splicing mechanism are known to be responsible for many diseases, including cystic fibrosis and familial dysautonomia.
Amir Goren, Eddo Kim, Gil Ast
openaire   +3 more sources

Spliced Leader Trapping Reveals Widespread Alternative Splicing Patterns in the Highly Dynamic Transcriptome of Trypanosoma brucei [PDF]

, 2021
Trans-splicing of leader sequences onto the 59ends of mRNAs is a widespread phenomenon in protozoa, nematodes and some chordates. Using parallel sequencing we have developed a method to simultaneously map 59splice sites and analyze the corresponding gene expression profile, that we term spliced leader trapping (SLT).
arxiv   +1 more source