Results 11 to 20 of about 249,606 (193)
Alternative splicing and genomic stability [PDF]
Physical Biology, 2004 6 ...
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Alternative Splice in Alternative Lice [PDF]
Molecular Biology and Evolution, 2015 Genomic and transcriptomics analyses have revealed human head and body lice to be almost genetically identical; although con-specific, they nevertheless occupy distinct ecological niches and have differing feeding patterns. Most importantly, while head lice are not known to be vector competent, body lice can transmit three serious bacterial diseases ...
John M. Clark +8 more
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Chromatin and Alternative Splicing [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2010 Alternative splicing affects more than 90% of human genes. Coupling between transcription and splicing has become crucial in the complex network underlying alternative splicing regulation. Because chromatin is the real template for nuclear transcription, changes in its structure, but also in the "reading" and "writing" of the histone code, could ...
Alló, M. +7 more
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Alternative Splicing in CKD [PDF]
Journal of the American Society of Nephrology, 2016 Alternative splicing (AS) has emerged in the postgenomic era as one of the main drivers of proteome diversity, with ≥94% of multiexon genes alternatively spliced in humans. AS is therefore one of the main control mechanisms for cell phenotype, and is a process deregulated in disease.
Stevens, Megan, Oltean, Sebastian
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Betacoronavirus-specific alternate splicing [PDF]
Genomics, 2021 AbstractViruses can subvert a number of cellular processes in order to block innate antiviral responses, and many viruses interact with cellular splicing machinery. SARS-CoV-2 infection was shown to suppress global mRNA splicing, and at least 10 SARS-CoV-2 proteins bind specifically to one or more human RNAs.
Deanne Taylor +15 more
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Alternative splicing and disease [PDF]
RNA Biology, 2008 Splicing is a molecular mechanism, by which introns are removed from an mRNA precursor and exons are ligated to form a mature mRNA. Mutations that cause defects in the splicing mechanism are known to be responsible for many diseases, including cystic fibrosis and familial dysautonomia.
Amir Goren, Eddo Kim, Gil Ast
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Alternative Splicing and Cancer
Journal of Nucleic Acids, 2012 Alternative splicing of premessenger RNAs is a key step in the gene expression process, which allows the synthesis of different products from the same gene and contributes to increase the complexity of the proteome coded by a limited number of genes. Specialized high-throughput technologies (RNA-Seq, splicing-sensitive microarrays) aiming at analyzing ...
Auboeuf D +3 more
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Spliced Leader Trapping Reveals Widespread Alternative Splicing Patterns in the Highly Dynamic Transcriptome of Trypanosoma brucei [PDF]
, 2021 Trans-splicing of leader sequences onto the 59ends of mRNAs is a widespread phenomenon in protozoa, nematodes and some chordates. Using parallel sequencing we have developed a method to simultaneously map 59splice sites and analyze the corresponding gene expression profile, that we term spliced leader trapping (SLT).
arxiv +1 more source
Alternative splicing and disease
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009 Almost all protein-coding genes are spliced and their majority is alternatively spliced. Alternative splicing is a key element in eukaryotic gene expression that increases the coding capacity of the human genome and an increasing number of examples illustrates that the selection of wrong splice sites causes human disease.
Tazi, Jamal +2 more
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The neurogenetics of alternative splicing [PDF]
Nature Reviews Neuroscience, 2016 Alternative precursor-mRNA splicing is a key mechanism for regulating gene expression in mammals and is controlled by specialized RNA-binding proteins. The misregulation of splicing is implicated in multiple neurological disorders. We describe recent mouse genetic studies of alternative splicing that reveal its critical role in both neuronal ...
Celine K. Vuong +2 more
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