Results 21 to 30 of about 249,606 (193)
Alternative splicing in cardiomyopathy [PDF]
Biophysical Reviews, 2018 Alternative splicing is an important mechanism used by the cell to generate greater transcriptomic and proteomic diversity from the genome. In the heart, alternative splicing is increasingly being recognised as an important layer of post-transcriptional gene regulation.
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Alternative Splicing in Angiogenesis
International Journal of Molecular Sciences, 2019 Alternative splicing of pre-mRNA allows the generation of multiple splice isoforms from a given gene, which can have distinct functions. In fact, splice isoforms can have opposing functions and there are many instances whereby a splice isoform acts as an inhibitor of canonical isoform function, thereby adding an additional layer of regulation to ...
Elizabeth Bowler, Sebastian Oltean
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Splicing and alternative splicing in rice and humans
BMB Reports, 2013 Rice is a monocot gramineous crop, and one of the most important staple foods. Rice is considered a model species for most gramineous crops. Extensive research on rice has provided critical guidance for other crops, such as maize and wheat. In recent years, climate change and exacerbated soil degradation have resulted in a variety of abiotic stresses ...
Lei Wang, Jianhua Zhou, Zhiguo E
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Approaches to link RNA secondary structures with splicing regulation [PDF]
Methods Mol Biol. 2014;1126:341-56, 2015 In higher eukaryotes, alternative splicing is usually regulated by protein factors, which bind to the pre-mRNA and affect the recognition of splicing signals. There is recent evidence that the secondary structure of the pre-mRNA may also play an important role in this process, either by facilitating or by hindering the interaction with factors and ...
arxiv +1 more source
Function of alternative splicing [PDF]
Gene, 2013 Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review the functions of alternative splicing events that have been experimentally determined. The overall function of alternative splicing is to increase the diversity of mRNAs expressed from the genome. Alternative splicing changes proteins encoded by mRNAs, which has
Zhaiyi Zhang +6 more
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Functional Splicing Network Reveals Extensive Regulatory Potential of the Core Spliceosomal Machinery [PDF]
MolCell. 2015 Jan 8;57(1):7-22, 2014 Pre-mRNA splicing relies on the poorly understood dynamic interplay between >150 protein components of the spliceosome. The steps at which splicing can be regulated remain largely unknown. We systematically analyzed the effect of knocking down the components of the splicing machinery on alternative splicing events relevant for cell proliferation and ...
arxiv +1 more source
Alternative Splicing in Myeloid Malignancies [PDF]
Biomedicines, 2021 Alternative RNA splicing (AS) is an essential physiologic function that diversifies the human proteome. AS also has a crucial role during cellular development. In fact, perturbations in RNA-splicing have been implicated in the development of several cancers, including myeloid malignancies.
Carmelo Gurnari +2 more
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Local tropicalizations of splice type surface singularities [PDF]
, 2021 Splice type surface singularities were introduced by Neumann and Wahl as a generalization of the class of Pham-Brieskorn-Hamm complete intersections of dimension two. Their construction depends on a weighted tree called a splice diagram. In this paper, we study these singularities from the tropical viewpoint.
arxiv +1 more source
RNA Alternative Splicing Prediction with Discrete Compositional Energy Network [PDF]
arXiv, 2021 A single gene can encode for different protein versions through a process called alternative splicing. Since proteins play major roles in cellular functions, aberrant splicing profiles can result in a variety of diseases, including cancers. Alternative splicing is determined by the gene's primary sequence and other regulatory factors such as RNA ...
arxiv
Latent rank change detection for analysis of splice-junction microarrays with nonlinear effects [PDF]
Annals of Applied Statistics 2011, Vol. 5, No. 1, 364-380, 2011 Alternative splicing of gene transcripts greatly expands the functional capacity of the genome, and certain splice isoforms may indicate specific disease states such as cancer. Splice junction microarrays interrogate thousands of splice junctions, but data analysis is difficult and error prone because of the increased complexity compared to ...
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