Results 21 to 30 of about 167,962 (232)

SIRT1 Involved in the Regulation of Alternative Splicing Affects the DNA Damage Response in Neural Stem Cells

Cellular Physiology and Biochemistry, 2018
Background/Aims: Alternative splicing and DNA damage exhibit cross-regulation, with not only DNA damage inducing changes in alternative splicing, but alternative splicing itself possibly modulating the DNA damage response (DDR).
Guangming Wang, Fangce Wang, Jie Ren, Yue Qiu, Wenjun Zhang, Shane Gao, Danjing Yang, Zhigang Wang, Aibin Liang, Zhengliang Gao, Jun Xu   +10 more
doaj   +1 more source

Transcriptome Bioinformatical Analysis of Vertebrate Stages of Schistosoma japonicum Reveals Alternative Splicing Events. [PDF]

PLoS ONE, 2015
Alternative splicing is a molecular process that contributes greatly to the diversification of proteome and to gene functions. Understanding the mechanisms of stage-specific alternative splicing can provide a better understanding of the development of ...
Xinye Wang, Xindong Xu, Xingyu Lu, Yuanbin Zhang, Weiqing Pan   +4 more
doaj   +1 more source

Alternative splicing in breast cancer

Journal of Bio-X Research, 2023
Alternative splicing allows a gene to produce multiple proteins and is the main source of human proteome diversity. Aberrant regulation of alternative splicing produces proteins with different structures and can lead to altered protein function ...
Xin Wen, Ze Yan, Li Sha
doaj   +1 more source

Significance of alternative splicing in cancer cells

Chinese Medical Journal, 2020
. Objective. Alternative splicing can generate various structural and functional protein isoforms. Recently, accumulating evidence shows a relationship between alternative splicing and cancer.
Fei Qi, Yong Li, Xue Yang, Yan-Ping Wu, Lian-Jun Lin, Xin-Min Liu, Li-Min Chen   +6 more
doaj   +1 more source

Advances in alternative splicing identification: deep learning and pantranscriptome

Frontiers in Plant Science, 2023
In plants, alternative splicing is a crucial mechanism for regulating gene expression at the post-transcriptional level, which leads to diverse proteins by generating multiple mature mRNA isoforms and diversify the gene regulation.
Fei Shen, Chenyang Hu, Chenyang Hu, Xin Huang, Hao He, Deng Yang, Jirong Zhao, Xiaozeng Yang   +7 more
doaj   +1 more source

Mapping splice QTLs reveals distinct transcriptional and post-transcriptional regulatory variation of gene expression and identifies putative alternative splicing variation mediating complex trait variation in pigs

BMC Genomics, 2023
Background Alternative splicing is an important step in gene expression, generating multiple isoforms for the same genes and greatly expanding the diversity of proteomes.
Fei Zhang, Deborah Velez-Irizarry, Catherine W. Ernst, Wen Huang   +3 more
doaj   +1 more source

DEDB: a database of Drosophila melanogaster exons in splicing graph form

BMC Bioinformatics, 2004
Background A wealth of quality genomic and mRNA/EST sequences in recent years has provided the data required for large-scale genome-wide analysis of alternative splicing.
Tan Tin, Lee Bernett TK, Ranganathan Shoba   +2 more
doaj   +1 more source

Alternative splicing is required for stage differentiation in malaria parasites

Genome Biology, 2019
Background In multicellular organisms, alternative splicing is central to tissue differentiation and identity. Unicellular protists lack multicellular tissue but differentiate into variable cell types during their life cycles.
Lee M. Yeoh, Christopher D. Goodman, Vanessa Mollard, Emma McHugh, V. Vern Lee, Angelika Sturm, Anton Cozijnsen, Geoffrey I. McFadden, Stuart A. Ralph   +8 more
doaj   +1 more source

Alternative promoters influence alternative splicing at the genomic level. [PDF]

PLoS ONE, 2008
BACKGROUND: More and more experiments have shown that transcription and mRNA processing are not two independent events but are tightly coupled to each other. Both promoter and transcription rate were found to influence alternative splicing.
Dedong Xin, Landian Hu, Xiangyin Kong
doaj   +1 more source

Betacoronavirus-specific alternate splicing [PDF]

Genomics, 2021
AbstractViruses can subvert a number of cellular processes in order to block innate antiviral responses, and many viruses interact with cellular splicing machinery. SARS-CoV-2 infection was shown to suppress global mRNA splicing, and at least 10 SARS-CoV-2 proteins bind specifically to one or more human RNAs.
Guy Karlebach, Bruce Aronow, Stephen B. Baylin, Daniel Butler, Jonathan Foox, Shawn Levy, Cem Meydan, Christopher Mozsary, Amanda M Saravia-Butler, Deanne M Taylor, Eve Wurtele, Christopher E Mason, Afshin Beheshti, Peter N Robinson   +13 more
openaire   +4 more sources