Results 31 to 40 of about 249,606 (193)
Evolution of Alternative Splicing in Eudicots [PDF]
Frontiers in Plant Science, 2019 Alternative pre-mRNA splicing (AS) is prevalent in plants and is involved in many interactions between plants and environmental stresses. However, the patterns and underlying mechanisms of AS evolution in plants remain unclear. By analyzing the transcriptomes of four eudicot species, we revealed that the divergence of AS is largely due to the gains and
Ling, Z. (Zhihao) +3 more
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Pharmacology of Modulators of Alternative Splicing [PDF]
Pharmacological Reviews, 2017 More than 95% of genes in the human genome are alternatively spliced to form multiple transcripts, often encoding proteins with differing or opposing function. The control of alternative splicing is now being elucidated, and with this comes the opportunity to develop modulators of alternative splicing that can control cellular function.
Bates, David O. +3 more
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Quantifying alternative splicing from paired-end RNA-sequencing data [PDF]
Annals of Applied Statistics 2014, Vol. 8, No. 1, 309-330, 2014 RNA-sequencing has revolutionized biomedical research and, in particular, our ability to study gene alternative splicing. The problem has important implications for human health, as alternative splicing may be involved in malfunctions at the cellular level and multiple diseases.
arxiv +1 more source
regulAS: A Bioinformatics Tool for the Integrative Analysis of Alternative Splicing Regulome using RNA-Seq data [PDF]
, 2023 The regulAS software package is a bioinformatics tool designed to support computational biology researchers in investigating regulatory mechanisms of splicing alterations through integrative analysis of large-scale RNA-Seq data from cancer and healthy human donors, characterized by TCGA and GTEx projects.
arxiv +1 more source
Integrating splice-isoform expression into genome-scale models characterizes breast cancer metabolism [PDF]
Bioinformatics, btx562, 34(3):494-501, 2018, 2018 Motivation: Despite being often perceived as the main contributors to cell fate and physiology, genes alone cannot predict cellular phenotype. During the process of gene expression, 95% of human genes can code for multiple proteins due to alternative splicing.
arxiv +1 more source
Complex Alternative Splicing [PDF]
, 2007 Alternative splicing is a powerful means of controlling gene expression and increasing protein diversity. Most genes express a limited number of mRNA isoforms, but there are several examples of genes that use alternative splicing to generate hundreds, thousands and even tens of thousands of isoforms.
Jung Woo Park, Brenton R. Graveley
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Alternative splicing and muscular dystrophy [PDF]
RNA Biology, 2010 Alternative splicing of pre-mRNAs is a major contributor to proteomic diversity and to the control of gene expression in higher eukaryotic cells. For this reasons, alternative splicing is tightly regulated in different tissues and developmental stages and its disruption can lead to a wide range of human disorders.
Pistoni M, Ghigna C, Gabellini D
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Alternative splicing and protein function [PDF]
BMC Bioinformatics, 2005 Abstract Background Alternative splicing is a major mechanism of generating protein diversity in higher eukaryotes. Although at least half, and probably more, of mammalian genes are alternatively spliced, it was not clear, whether the frequency of alternative splicing is the same in different functional categories.
Neverov, A.D. +5 more
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Crosscap numbers of alternating knots via unknotting splices [PDF]
Internat. J. Math. 31 (2020), no. 7, 2050057, 30 pp, 2019 Ito-Takimura recently defined a splice-unknotting number $u^-(D)$ for knot diagrams. They proved that this number provides an upper bound for the crosscap number of any prime knot, asking whether equality holds in the alternating case. We answer their question in the affirmative.
arxiv +1 more source
Alternative Splicing and Tumor Progression [PDF]
Current Genomics, 2008 Alternative splicing is a key molecular mechanism for increasing the functional diversity of the eukaryotic proteomes. A large body of experimental data implicates aberrant splicing in various human diseases, including cancer. Both mutations in cis-acting splicing elements and alterations in the expression and/or activity of splicing regulatory factors
Ghigna C, Valacca C, Biamonti G
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