Results 31 to 40 of about 3,593,907 (372)

SIRT1 Involved in the Regulation of Alternative Splicing Affects the DNA Damage Response in Neural Stem Cells

Cellular Physiology and Biochemistry, 2018
Background/Aims: Alternative splicing and DNA damage exhibit cross-regulation, with not only DNA damage inducing changes in alternative splicing, but alternative splicing itself possibly modulating the DNA damage response (DDR).
Guangming Wang, Fangce Wang, Jie Ren, Yue Qiu, Wenjun Zhang, Shane Gao, Danjing Yang, Zhigang Wang, Aibin Liang, Zhengliang Gao, Jun Xu   +10 more
doaj   +1 more source

Predominant contribution of cis-regulatory divergence in the evolution of mouse alternative splicing [PDF]

, 2015
Divergence of alternative splicing represents one of the major driving forces to shape phenotypic diversity during evolution. However, the extent to which these divergences could be explained by the evolving cis-regulatory versus trans-acting factors ...
Ballegeer, Marlies, Chen, Wei, Gao, Qingsong, Libert, Claude, Sun, Wei   +4 more
core   +2 more sources

Corepressor diversification by alternative mRNA splicing is species specific. [PDF]

, 2016
BackgroundSMRT and NCoR are corepressor paralogs that help mediate transcriptional repression by a variety of transcription factors, including the nuclear hormone receptors.
Goodson, Michael L, Privalsky, Martin L, Snyder, Chelsea A   +2 more
core   +2 more sources

The Alternative Choice of Constitutive Exons throughout Evolution [PDF]

, 2007
Alternative cassette exons are known to originate from two processes exonization of intronic sequences and exon shuffling. Herein, we suggest an additional mechanism by which constitutively spliced exons become alternative cassette exons during evolution.
Adi Doron-Faigenboim, Amir Goren, Eddo Kim, Galit Lev-Maor, Gil Ast, Hadas Keren, Lisa Stubbs, Noa Sela, Shelly Leibman-Barak, Tal Pupko   +9 more
core   +5 more sources

Significance of alternative splicing in cancer cells

Chinese Medical Journal, 2020
. Objective. Alternative splicing can generate various structural and functional protein isoforms. Recently, accumulating evidence shows a relationship between alternative splicing and cancer.
Fei Qi, Yong Li, Xue Yang, Yan-Ping Wu, Lian-Jun Lin, Xin-Min Liu, Li-Min Chen   +6 more
doaj   +1 more source

Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons [PDF]

, 2014
Alternative splicing—the production of multiple messenger RNA isoforms from a single gene—is regulated in part by RNA binding proteins. While the RBPs transformer2 alpha (Tra2α) and Tra2β have both been implicated in the regulation of alternative ...
Austin, Caroline A., Best, Andrew, Chabot, Benoit, Cheong Lee, Ka, Cowell, Ian G., Curk, Tomaz, Dalgliesh, Caroline, Danilenko, Marina, Elliott, David J., Hong, Elaine, Hussain, Rafiq, James, Katherine, Keavney, Bernard, Kheirolahi-Kouhestani, Mahsa, Klinck, Roscoe, Santibanez Koref, Mauro, Tyson-Capper, Alison, Venables, Julian P., Wipat, Anil, Xu, Yaobo   +19 more
core   +2 more sources

Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression

Nature Communications, 2020
While most monogenic diseases are caused by loss or reduction of protein function, the need for technologies that can selectively increase levels of protein in native tissues remains.
K. Lim, Zhou Han, H. Y. Jeon, Jacob Kach, Enxuan Jing, Sebastien M. Weyn-Vanhentenryck, Mikaela Downs, Anna Corrionero, R. Oh, J. Scharner, Aditya Venkatesh, Sophina Ji, G. Liau, B. Ticho, H. Nash, I. Aznarez   +15 more
semanticscholar   +1 more source

A bioinformatic analysis identifies circadian expression of splicing factors and time-dependent alternative splicing events in the HD-MY-Z cell line [PDF]

, 2019
The circadian clock regulates key cellular processes and its dysregulation is associated to several pathologies including cancer. Although the transcriptional regulation of gene expression by the clock machinery is well described, the role of the clock ...
Abreu, Mónica, Astaburuaga, Rosario, Basti, Alireza, Genov, Nikolai, Relógio, Angela   +4 more
core   +1 more source

Advances in alternative splicing identification: deep learning and pantranscriptome

Frontiers in Plant Science, 2023
In plants, alternative splicing is a crucial mechanism for regulating gene expression at the post-transcriptional level, which leads to diverse proteins by generating multiple mature mRNA isoforms and diversify the gene regulation.
Fei Shen, Chenyang Hu, Chenyang Hu, Xin Huang, Hao He, Deng Yang, Jirong Zhao, Xiaozeng Yang   +7 more
doaj   +1 more source

FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing [PDF]

, 2018
FOXP3 promotes the development and function of regulatory T cells mainly through regulating the transcription of target genes. RNA alternative splicing has been implicated in a wide range of physiological and pathophysiological processes.
Du, Jianguang, Wang, Qun, Zhou, Baohua, Ziegler, Steven F.   +3 more
core   +1 more source