Results 31 to 40 of about 326,335 (355)

Alternative Splicing in Angiogenesis

International Journal of Molecular Sciences, 2019
Alternative splicing of pre-mRNA allows the generation of multiple splice isoforms from a given gene, which can have distinct functions. In fact, splice isoforms can have opposing functions and there are many instances whereby a splice isoform acts as an inhibitor of canonical isoform function, thereby adding an additional layer of regulation to ...
Elizabeth Bowler, Sebastian Oltean
openaire   +4 more sources

Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons [PDF]

, 2014
Alternative splicing—the production of multiple messenger RNA isoforms from a single gene—is regulated in part by RNA binding proteins. While the RBPs transformer2 alpha (Tra2α) and Tra2β have both been implicated in the regulation of alternative ...
Austin, Caroline A., Best, Andrew, Chabot, Benoit, Cheong Lee, Ka, Cowell, Ian G., Curk, Tomaz, Dalgliesh, Caroline, Danilenko, Marina, Elliott, David J., Hong, Elaine, Hussain, Rafiq, James, Katherine, Keavney, Bernard, Kheirolahi-Kouhestani, Mahsa, Klinck, Roscoe, Santibanez Koref, Mauro, Tyson-Capper, Alison, Venables, Julian P., Wipat, Anil, Xu, Yaobo   +19 more
core   +2 more sources

Splicing and alternative splicing in rice and humans

BMB Reports, 2013
Rice is a monocot gramineous crop, and one of the most important staple foods. Rice is considered a model species for most gramineous crops. Extensive research on rice has provided critical guidance for other crops, such as maize and wheat. In recent years, climate change and exacerbated soil degradation have resulted in a variety of abiotic stresses ...
Lei Wang, Jianhua Zhou, Zhiguo E
openaire   +5 more sources

Mapping splice QTLs reveals distinct transcriptional and post-transcriptional regulatory variation of gene expression and identifies putative alternative splicing variation mediating complex trait variation in pigs

BMC Genomics, 2023
Background Alternative splicing is an important step in gene expression, generating multiple isoforms for the same genes and greatly expanding the diversity of proteomes.
Fei Zhang, Deborah Velez-Irizarry, Catherine W. Ernst, Wen Huang   +3 more
doaj   +1 more source

Advances in alternative splicing identification: deep learning and pantranscriptome

Frontiers in Plant Science, 2023
In plants, alternative splicing is a crucial mechanism for regulating gene expression at the post-transcriptional level, which leads to diverse proteins by generating multiple mature mRNA isoforms and diversify the gene regulation.
Fei Shen, Chenyang Hu, Chenyang Hu, Xin Huang, Hao He, Deng Yang, Jirong Zhao, Xiaozeng Yang   +7 more
doaj   +1 more source

RNA-Seq analysis of splicing in Plasmodium falciparum uncovers new splice junctions, alternative splicing and splicing of antisense transcripts. [PDF]

, 2011
Over 50% of genes in Plasmodium falciparum, the deadliest human malaria parasite, contain predicted introns, yet experimental characterization of splicing in this organism remains incomplete.
DeRisi, Joseph L, Dimon, Michelle T, Sorber, Katherine   +2 more
core   +3 more sources

Alternative splicing: Human disease and quantitative analysis from high-throughput sequencing

Computational and Structural Biotechnology Journal, 2021
Alternative splicing contributes to the majority of protein diversity in higher eukaryotes by allowing one gene to generate multiple distinct protein isoforms. It adds another regulation layer of gene expression.
Wei Jiang, Liang Chen
doaj  

DEDB: a database of Drosophila melanogaster exons in splicing graph form

BMC Bioinformatics, 2004
Background A wealth of quality genomic and mRNA/EST sequences in recent years has provided the data required for large-scale genome-wide analysis of alternative splicing.
Tan Tin, Lee Bernett TK, Ranganathan Shoba   +2 more
doaj   +1 more source

Alternative promoters influence alternative splicing at the genomic level. [PDF]

PLoS ONE, 2008
BACKGROUND: More and more experiments have shown that transcription and mRNA processing are not two independent events but are tightly coupled to each other. Both promoter and transcription rate were found to influence alternative splicing.
Dedong Xin, Landian Hu, Xiangyin Kong
doaj   +1 more source

FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing [PDF]

, 2018
FOXP3 promotes the development and function of regulatory T cells mainly through regulating the transcription of target genes. RNA alternative splicing has been implicated in a wide range of physiological and pathophysiological processes.
Du, Jianguang, Wang, Qun, Zhou, Baohua, Ziegler, Steven F.   +3 more
core   +1 more source