Alternative splicing is required for stage differentiation in malaria parasites
Genome Biology, 2019 Background In multicellular organisms, alternative splicing is central to tissue differentiation and identity. Unicellular protists lack multicellular tissue but differentiate into variable cell types during their life cycles.
Lee M. Yeoh +8 more
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Function of alternative splicing [PDF]
Gene, 2013 Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review the functions of alternative splicing events that have been experimentally determined. The overall function of alternative splicing is to increase the diversity of mRNAs expressed from the genome. Alternative splicing changes proteins encoded by mRNAs, which has
Zhaiyi Zhang +6 more
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Extraction of Transcript Diversity from Scientific Literature [PDF]
, 2005 Transcript diversity generated by alternative splicing and associated mechanisms contributes heavily to the functional complexity of biological systems.
Lars J Jensen +4 more
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Alternative Splicing in Neurogenesis and Brain Development
Frontiers in Molecular Biosciences, 2018 Alternative splicing of precursor mRNA is an important mechanism that increases transcriptomic and proteomic diversity and also post-transcriptionally regulates mRNA levels.
Chun-Hao Su +4 more
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The Perils of Navigating Activity-Dependent Alternative Splicing of Neurexins
Frontiers in Molecular Neuroscience, 2021 Neurexins are presynaptic cell-adhesion molecules essential for synaptic function that are expressed in thousands of alternatively spliced isoforms. Recent studies suggested that alternative splicing at splice site 4 (SS4) of Nrxn1 is tightly regulated ...
Kif Liakath-Ali +3 more
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Intracerebral Hemorrhage and Ischemic Stroke of Different Etiologies Have Distinct Alternatively Spliced mRNA Profiles in the Blood: a Pilot RNA-seq Study. [PDF]
, 2015 Whole transcriptome studies have used 3'-biased expression microarrays to study genes regulated in the blood of stroke patients. However, alternatively spliced messenger RNA isoforms have not been investigated for ischemic stroke or intracerebral ...
Ander, Bradley P +8 more
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Evolution of Alternative Splicing in Eudicots [PDF]
Frontiers in Plant Science, 2019 Alternative pre-mRNA splicing (AS) is prevalent in plants and is involved in many interactions between plants and environmental stresses. However, the patterns and underlying mechanisms of AS evolution in plants remain unclear. By analyzing the transcriptomes of four eudicot species, we revealed that the divergence of AS is largely due to the gains and
Ling, Z. (Zhihao) +3 more
openaire +7 more sources
The implications of alternative pre-mRNA splicing in cell signal transduction
Experimental and Molecular Medicine, 2023 Cells produce multiple mRNAs through alternative splicing, which ensures proteome diversity. Because most human genes undergo alternative splicing, key components of signal transduction pathways are no exception.
Sunkyung Choi, Namjoon Cho, Kee K. Kim
doaj +1 more source
Multiple breast cancer risk variants are associated with differential transcript isoform expression in tumors. [PDF]
, 2015 Genome-wide association studies have identified over 70 single-nucleotide polymorphisms (SNPs) associated with breast cancer. A subset of these SNPs are associated with quantitative expression of nearby genes, but the functional effects of the majority ...
Brenner, Steven E +8 more
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The importance of being divisible by three in alternative splicing [PDF]
, 2005 Alternative splicing events that are conserved in orthologous genes in different species are commonly viewed as reliable evidence of authentic, functionally significant alternative splicing events.
Ast, Gil, Magen, Alon
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