FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing [PDF]
, 2018 FOXP3 promotes the development and function of regulatory T cells mainly through regulating the transcription of target genes. RNA alternative splicing has been implicated in a wide range of physiological and pathophysiological processes.
Du, Jianguang +3 more
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DEDB: a database of
BMC Bioinformatics, 2004 Background A wealth of quality genomic and mRNA/EST sequences in recent years has provided the data required for large-scale genome-wide analysis of alternative splicing.
Tan Tin +2 more
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Alternative promoters influence alternative splicing at the genomic level. [PDF]
PLoS ONE, 2008 BACKGROUND: More and more experiments have shown that transcription and mRNA processing are not two independent events but are tightly coupled to each other. Both promoter and transcription rate were found to influence alternative splicing.
Dedong Xin, Landian Hu, Xiangyin Kong
doaj +1 more source
Approaches to link RNA secondary structures with splicing regulation [PDF]
Methods Mol Biol. 2014;1126:341-56, 2015 In higher eukaryotes, alternative splicing is usually regulated by protein factors, which bind to the pre-mRNA and affect the recognition of splicing signals. There is recent evidence that the secondary structure of the pre-mRNA may also play an important role in this process, either by facilitating or by hindering the interaction with factors and ...
arxiv +1 more source
Alternative splicing is required for stage differentiation in malaria parasites
Genome Biology, 2019 Background In multicellular organisms, alternative splicing is central to tissue differentiation and identity. Unicellular protists lack multicellular tissue but differentiate into variable cell types during their life cycles.
Lee M. Yeoh +8 more
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Functional Splicing Network Reveals Extensive Regulatory Potential of the Core Spliceosomal Machinery [PDF]
MolCell. 2015 Jan 8;57(1):7-22, 2014 Pre-mRNA splicing relies on the poorly understood dynamic interplay between >150 protein components of the spliceosome. The steps at which splicing can be regulated remain largely unknown. We systematically analyzed the effect of knocking down the components of the splicing machinery on alternative splicing events relevant for cell proliferation and ...
arxiv +1 more source
Function of alternative splicing [PDF]
Gene, 2013 Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review the functions of alternative splicing events that have been experimentally determined. The overall function of alternative splicing is to increase the diversity of mRNAs expressed from the genome. Alternative splicing changes proteins encoded by mRNAs, which has
Zhaiyi Zhang +6 more
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RNA-Seq analysis of splicing in Plasmodium falciparum uncovers new splice junctions, alternative splicing and splicing of antisense transcripts. [PDF]
, 2011 Over 50% of genes in Plasmodium falciparum, the deadliest human malaria parasite, contain predicted introns, yet experimental characterization of splicing in this organism remains incomplete.
DeRisi, Joseph L +2 more
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Local tropicalizations of splice type surface singularities [PDF]
, 2021 Splice type surface singularities were introduced by Neumann and Wahl as a generalization of the class of Pham-Brieskorn-Hamm complete intersections of dimension two. Their construction depends on a weighted tree called a splice diagram. In this paper, we study these singularities from the tropical viewpoint.
arxiv +1 more source
Intracerebral Hemorrhage and Ischemic Stroke of Different Etiologies Have Distinct Alternatively Spliced mRNA Profiles in the Blood: a Pilot RNA-seq Study. [PDF]
, 2015 Whole transcriptome studies have used 3'-biased expression microarrays to study genes regulated in the blood of stroke patients. However, alternatively spliced messenger RNA isoforms have not been investigated for ischemic stroke or intracerebral ...
Ander, Bradley P +8 more
core +2 more sources