Results 1 to 10 of about 261,635 (205)

Multiparametric Material Functionality of Microtissue‐Based In Vitro Models as Alternatives to Animal Testing [PDF]

open access: yesAdvanced Science, 2022
With the definition of the 3R principle by Russel and Burch in 1959, the search for an adequate substitute for animal testing has become one of the most important tasks and challenges of this time, not only from an ethical, but also from a scientific ...
Elena Stengelin   +2 more
doaj   +2 more sources

Novel computational models offer alternatives to animal testing for assessing eye irritation and corrosion potential of chemicals [PDF]

open access: yesArtificial Intelligence in the Life Sciences, 2021
Eye irritation and corrosion are fundamental considerations in developing chemicals to be used in or near the eye, from cleaning products to ophthalmic solutions.
Arthur C. Silva   +8 more
doaj   +2 more sources

A State-of-the-Art Review on the Alternatives to Animal Testing for the Safety Assessment of Cosmetics [PDF]

open access: goldCosmetics, 2022
Almost a decade after the stipulated deadline in the 7th amendment to the EU Cosmetics Directive, which bans the marketing of animal-tested cosmetics in the EU from 2013, animal experimentation for cosmetic-related purposes remains a topic of animated ...
Rita José Silva, Slobodanka Tamburic
doaj   +2 more sources

Humanising nanotoxicology: replacement of animal-derived products in the application of integrated approaches to testing and assessment of nanomaterial inhalation hazard [PDF]

open access: yesFrontiers in Bioengineering and Biotechnology
Over the past decade, the development of nanomaterials (NMs) has surged, highlighting their potential benefits across multiple industries. However, concerns regarding human and environmental exposure remain significant.
Roma Fraser   +6 more
doaj   +2 more sources

Using in silico tools to predict flame retardant metabolites for more informative exposomics-based approaches

open access: yesFrontiers in Toxicology, 2023
Introduction: The positive identification of xenobiotics and their metabolites in human biosamples is an integral aspect of exposomics research, yet challenges in compound annotation and identification continue to limit the feasibility of comprehensive ...
Breanne Kincaid   +6 more
doaj   +1 more source

Similarities and Differences in Gene Expression Networks Between the Breast Cancer Cell Line Michigan Cancer Foundation-7 and Invasive Human Breast Cancer Tissues

open access: yesFrontiers in Artificial Intelligence, 2021
Failure to adequately characterize cell lines, and understand the differences between in vitro and in vivo biology, can have serious consequences on the translatability of in vitro scientific studies to human clinical trials.
Vy Tran   +6 more
doaj   +1 more source

Oligodendrogenesis and myelination tracing in a CRISPR/Cas9-engineered brain microphysiological system

open access: yesFrontiers in Cellular Neuroscience, 2023
IntroductionOligodendrocytes (OLs) are the myelin-forming cells of the central nervous system (CNS). Although OLs can be differentiated from human-induced pluripotent stem cells (hiPSCs), the in vitro modeling of axon myelination in human cells remains ...
July Carolina Romero   +6 more
doaj   +1 more source

Editorial: New approach methods in immunology [PDF]

open access: yesFrontiers in Immunology
Thomas Hartung   +5 more
doaj   +2 more sources

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