Results 1 to 10 of about 50,888 (294)

Novel computational models offer alternatives to animal testing for assessing eye irritation and corrosion potential of chemicals. [PDF]

Artif Intell Life Sci, 2021
Eye irritation and corrosion are fundamental considerations in developing chemicals to be used in or near the eye, from cleaning products to ophthalmic solutions.
Silva AC, Borba JVVB, Alves VM, Hall SUS, Furnham N, Kleinstreuer N, Muratov E, Tropsha A, Andrade CH.   +8 more
europepmc   +3 more sources

Antibody-based alternatives to animal testing for toxin detection and antitoxin evaluation. [PDF]

Front Toxicol
Animal experiments have long played a central role in biomedical research and toxicology, yet their limitations in translational accuracy and ethical concerns have intensified the demand for reliable alternatives.
Chang SH, Jang J, Yang W, Lee NK, Choi S, Jung HI, Kim W, Cha B, Yoon SJ, Noh JY, Lee J.   +10 more
europepmc   +4 more sources

Alternatives to animal testing: A review. [PDF]

Saudi Pharm J, 2015
The number of animals used in research has increased with the advancement of research and development in medical technology. Every year, millions of experimental animals are used all over the world. The pain, distress and death experienced by the animals during scientific experiments have been a debating issue for a long time. Besides the major concern
Doke SK, Dhawale SC.
europepmc   +5 more sources

Multiparametric Material Functionality of Microtissue-Based In Vitro Models as Alternatives to Animal Testing. [PDF]

Adv Sci (Weinh), 2022
With the definition of the 3R principle by Russel and Burch in 1959, the search for an adequate substitute for animal testing has become one of the most important tasks and challenges of this time, not only from an ethical, but also from a scientific ...
Stengelin E, Thiele J, Seiffert S.
europepmc   +2 more sources

Can alternatives to animal testing yield useful information regarding biological mechanisms and drug discovery? [PDF]

J Orthop Translat
Establish alternative strategies to standard animal experiments decrease animal utilization and simultaneously enhance the reliability of biological and disease models.
Gao Q, Chow SK, Shinohara I, Murayama M, Susuki Y, Morita M, Ma C, Goodman SB.   +7 more
europepmc   +2 more sources

A State-of-the-Art Review on the Alternatives to Animal Testing for the Safety Assessment of Cosmetics [PDF]

Cosmetics, 2022
Almost a decade after the stipulated deadline in the 7th amendment to the EU Cosmetics Directive, which bans the marketing of animal-tested cosmetics in the EU from 2013, animal experimentation for cosmetic-related purposes remains a topic of animated ...
Rita José Silva, Slobodanka Tamburic
doaj   +2 more sources

AI: the Apollo guidance computer of the Exposome moonshot. [PDF]

Front Artif Intell
The Exposome—the totality of environmental exposures across a lifetime—remains one of the most significant challenges in understanding and preventing human disease.
Sillé FCM, Hartung T.
europepmc   +2 more sources

Using in silico tools to predict flame retardant metabolites for more informative exposomics-based approaches

Frontiers in Toxicology, 2023
Introduction: The positive identification of xenobiotics and their metabolites in human biosamples is an integral aspect of exposomics research, yet challenges in compound annotation and identification continue to limit the feasibility of comprehensive ...
Breanne Kincaid, Przemyslaw Piechota, Emily Golden, Mikhail Maertens, Thomas Hartung, Thomas Hartung, Alexandra Maertens   +6 more
doaj   +1 more source

Similarities and Differences in Gene Expression Networks Between the Breast Cancer Cell Line Michigan Cancer Foundation-7 and Invasive Human Breast Cancer Tissues

Frontiers in Artificial Intelligence, 2021
Failure to adequately characterize cell lines, and understand the differences between in vitro and in vivo biology, can have serious consequences on the translatability of in vitro scientific studies to human clinical trials.
Vy Tran, Robert Kim, Mikhail Maertens, Thomas Hartung, Thomas Hartung, Thomas Hartung, Alexandra Maertens   +6 more
doaj   +1 more source

Oligodendrogenesis and myelination tracing in a CRISPR/Cas9-engineered brain microphysiological system

Frontiers in Cellular Neuroscience, 2023
IntroductionOligodendrocytes (OLs) are the myelin-forming cells of the central nervous system (CNS). Although OLs can be differentiated from human-induced pluripotent stem cells (hiPSCs), the in vitro modeling of axon myelination in human cells remains ...
July Carolina Romero, Cynthia Berlinicke, Sharon Chow, Yukan Duan, Yifei Wang, Xitiz Chamling, Lena Smirnova   +6 more
doaj   +1 more source