Alternatives to animal testing: A review. [PDF]
Saudi Pharm J, 2015 The number of animals used in research has increased with the advancement of research and development in medical technology. Every year, millions of experimental animals are used all over the world. The pain, distress and death experienced by the animals during scientific experiments have been a debating issue for a long time. Besides the major concern
Doke SK, Dhawale SC.
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Alternatives to animal testing to assess MASH drugs and hepatotoxicity. [PDF]
Hepatology, 2023 The Food and Drug Administration (FDA) Modernization Act 2.0 “allows for alternatives to animal testing for purposes of drug and biological product applications.” This provides an opportunity to develop and improve alternatives to animal studies to assess drugs in the liver.
Brenner DA, Brenner DA.
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Multiparametric Material Functionality of Microtissue‐Based In Vitro Models as Alternatives to Animal Testing [PDF]
Advanced Science, 2022 With the definition of the 3R principle by Russel and Burch in 1959, the search for an adequate substitute for animal testing has become one of the most important tasks and challenges of this time, not only from an ethical, but also from a scientific ...
Elena Stengelin +2 more
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Novel computational models offer alternatives to animal testing for assessing eye irritation and corrosion potential of chemicals [PDF]
Artificial Intelligence in the Life Sciences, 2021 Eye irritation and corrosion are fundamental considerations in developing chemicals to be used in or near the eye, from cleaning products to ophthalmic solutions.
Arthur C. Silva +8 more
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Alternatives to animal testing: current status and future perspectives. [PDF]
Arch Toxicol, 2011 On the occasion of the 20th anniversary of the Center for Alternative Methods to Animal Experiments (ZEBET), an international symposium was held at the German Federal Institute for Risk Assessment (BfR) in Berlin. At the same time, this symposium was meant to celebrate the 50th anniversary of the publication of the book "The Principles of Humane ...
Liebsch M +8 more
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Antibody-based alternatives to animal testing for toxin detection and antitoxin evaluation [PDF]
Frontiers in ToxicologyAnimal experiments have long played a central role in biomedical research and toxicology, yet their limitations in translational accuracy and ethical concerns have intensified the demand for reliable alternatives.
Seo-Hyuk Chang +17 more
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Can alternatives to animal testing yield useful information regarding biological mechanisms and drug discovery? [PDF]
Journal of Orthopaedic TranslationEstablish alternative strategies to standard animal experiments decrease animal utilization and simultaneously enhance the reliability of biological and disease models.
Qi Gao +7 more
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AI: the Apollo guidance computer of the Exposome moonshot [PDF]
Frontiers in Artificial IntelligenceThe Exposome—the totality of environmental exposures across a lifetime—remains one of the most significant challenges in understanding and preventing human disease.
Fenna C. M. Sillé +3 more
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Alternatives to Animal Testing [PDF]
Journal of Toxicology: Cutaneous and Ocular Toxicology, 1994 (1996). Alternatives to Animal Testing. Journal of Toxicology: Cutaneous and Ocular Toxicology: Vol. 15, No. 1, pp. 29-31.
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Frontiers in Toxicology, 2023 Introduction: The positive identification of xenobiotics and their metabolites in human biosamples is an integral aspect of exposomics research, yet challenges in compound annotation and identification continue to limit the feasibility of comprehensive ...
Breanne Kincaid +6 more
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