Results 31 to 40 of about 50,888 (294)

QSAR Models for the Prediction of Dietary Biomagnification Factor in Fish

Toxics, 2023
Xenobiotics released in the environment can be taken up by aquatic and terrestrial organisms and can accumulate at higher concentrations through the trophic chain.
Linda Bertato, Nicola Chirico, Ester Papa   +2 more
doaj   +1 more source

Predicting the Bioconcentration Factor in Fish from Molecular Structures

Toxics, 2022
The bioconcentration factor (BCF) is one of the metrics used to evaluate the potential of a substance to bioaccumulate into aquatic organisms. In this work, linear and non-linear regression QSARs were developed for the prediction of log BCF using ...
Linda Bertato, Nicola Chirico, Ester Papa   +2 more
doaj   +1 more source

Predicting toxicity of chemicals: software beats animal testing

EFSA Journal, 2019
We created earlier a large machine‐readable database of 10,000 chemicals and 800,000 associated studies by natural language processing of the public parts of Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) registrations until
Thomas Hartung
doaj   +1 more source

Effect of sub-chronic exposure to cigarette smoke, electronic cigarette and waterpipe on human lung epithelial barrier function

BMC Pulmonary Medicine, 2020
Background Taking into consideration a recent surge of a lung injury condition associated with electronic cigarette use, we devised an in vitro model of sub-chronic exposure of human bronchial epithelial cells (HBECs) in air-liquid interface, to ...
Baishakhi Ghosh, Hermes Reyes-Caballero, Sevcan Gül Akgün-Ölmez, Kristine Nishida, Lakshmana Chandrala, Lena Smirnova, Shyam Biswal, Venkataramana K. Sidhaye   +7 more
doaj   +1 more source

Automated measurement of the spontaneous tail coiling of zebrafish embryos as a sensitive behavior endpoint using a workflow in KNIME

MethodsX, 2021
Neuroactive substances are the largest group of chemicals detected in European surface waters. Mixtures of neuroactive substances occurring at low concentrations can induce adverse neurological effects in humans and organisms in the environment ...
Afolarin O. Ogungbemi, Elisabet Teixido, Riccardo Massei, Stefan Scholz, Eberhard Küster   +4 more
doaj   +1 more source

Give meaning to alternative methods to animal testing

ALTEX, 2019
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Arti Ahluwalia, Anna Maria Bassi
openaire   +3 more sources

Brain organoids and organoid intelligence from ethical, legal, and social points of view

Frontiers in Artificial Intelligence
Human brain organoids, aka cerebral organoids or earlier “mini-brains”, are 3D cellular models that recapitulate aspects of the developing human brain.
Thomas Hartung, Thomas Hartung, Itzy E. Morales Pantoja, Lena Smirnova   +3 more
doaj   +1 more source

Guidance on assessing the methodological and reporting quality of toxicologically relevant studies: A scoping review

Environment International, 2016
Assessments of methodological and reporting quality are critical to adequately judging the credibility of a study's conclusions and to gauging its potential reproducibility.
Gbeminiyi O. Samuel, Sebastian Hoffmann, Robert A. Wright, Manoj Mathew Lalu, Grace Patlewicz, Richard A. Becker, George L. DeGeorge, Dean Fergusson, Thomas Hartung, R. Jeffrey Lewis, Martin L. Stephens   +10 more
doaj   +1 more source

Replacement Strategies for Animal Studies in Inhalation Testing

Sci, 2021
Animal testing is mandatory in drug testing and is the gold standard for toxicity and efficacy evaluations. This situation is expected to change in the future as the 3Rs principle, which stands for the replacement, reduction, and refinement of the use of
Eleonore Fröhlich
doaj   +1 more source

Alternatives to animal testing for assessing transplacental transfer

Translational and Regulatory Sciences
Takeshi Hori, Hirokazu Kaji
openalex   +3 more sources