Results 61 to 70 of about 843,251 (286)

A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat

Advanced Science, EarlyView.
An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su, Haosen Yang, Xiaokai Li, Tingting Jiang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Li Li, Hongping Zhang, Linjie Wang   +10 more
wiley   +1 more source

Tumor cell-derived EMP1 is essential for cancer-associated fibroblast infiltration in tumor microenvironment of triple-negative breast cancer

Cell Death and Disease
The role of epithelial membrane protein 1 (EMP1) in tumor microenvironment (TME) remodeling has not yet been elucidated. In addition, the biological function of EMP1 in triple-negative breast cancer (TNBC) is largely unclear.
Qi Wang, Dandan Li, Haixiu Ma, Zengyan Li, Juan Wu, Jinwan Qiao, Jun Liu, Jing Zhao, Ronghua Ma, Lin Tian, Lei Zhang, Jianye Yang, Jianing Wang, Shanshan Qin, Zhanhai Su   +14 more
doaj   +1 more source

Auger spectroscopy of stratospheric particles : the influence of aerosols on interplanetary dust [PDF]

, 1985
Particle collections from the stratosphere via either the JSC Curatorial Program or the U2 Program (NASA Ames) occur between 16km and 19km altitude and are usually part of ongoing experiments to measure parameters related to the aerosol layer.
Mackinnon, Ian D.R., Mogk, David W., Rietmeijer, Frans J.M.   +2 more
core   +1 more source

Local adaptation with high gene flow: temperature parameters drive adaptation to altitude in the common frog (Rana temporaria) [PDF]

, 2014
Both environmental and genetic influences can result in phenotypic variation. Quantifying the relative contributions of local adaptation and phenotypic plasticity to phenotypes is key to understanding the effect of environmental variation on populations.
Biek, R., Mable, B.K., Muir, A.P., Thomas, R.   +3 more
core   +2 more sources

Pan‐3D Genome Analysis Reveals the Roles of Structural Variation in Chicken Chromatin Architectures, Domestication and Production Traits

Advanced Science, EarlyView.
This study firstly presents a comprehensive and high‐resolution pan‐3D genome resource in chicken. Our findings reveal the role of structural variations in 3D genome architectures, and how they influence the domestication process and production traits at the 3D genome level.
Zhen Zhou, Danfeng Cai, Changbin Zhao, Siyu Zhang, Jiahao Li, Zhaofeng Zhang, Shaofen Kong, Xin Yang, Xiaoli Zhou, Farhad Bordbar, Fayi Chen, Yaohuan Xu, Zhe Zhang, Lihong Gu, Zhenhui Li, Xiquan Zhang, Wen Luo, Jingting Shu, Bolin Cai, Qinghua Nie   +19 more
wiley   +1 more source

Altitude hypoxia and hypoxemia: pathogenesis and management

Signal Transduction and Targeted Therapy
At high altitudes, which typically exceed 2500 m, approximately 80 million people reside permanently, with over a million visitors annually. The primary effect of high altitude is hypobaric hypoxia, which leads to decreased oxygen availability and a ...
Chunmei Cai, Guohua Ni, Lei Chen, Cheng Deng, Shengjun Chai, Rui Wang, Rong Zhang, Fengming Luo, Ri-Li Ge   +8 more
doaj   +1 more source

UHPLC-QTOFMS-Based Metabolomic Analysis of the Hippocampus in Hypoxia Preconditioned Mouse

Frontiers in Physiology, 2019
Background: Hypoxia appears in a number of extreme environments, including high altitudes, the deep sea, and during aviation, and occurs in cancer, cardiovascular disease, respiratory failures and neurological disorders. Though it is well recognized that
Wen-Ting Liao, Jie Liu, Jie Liu, Si-Min Zhou, Si-Min Zhou, Gang Xu, Gang Xu, Yu-Qi Gao, Yu-Qi Gao, Wen-Yuan Liu   +9 more
doaj   +1 more source

Meter‐Scale Ultra‐Large‐Area Flexible Electroluminescent Devices Enabled by Aerosol Spraying

Advanced Science, EarlyView.
This work presents a simple aerosol spraying method using modified luminescent ink to fabricate meter‐scale flexible alternating current electroluminescent (ACEL) devices. Enhanced particle dispersibility and film uniformity yield impressive brightness up to 500 cd m−2, positioning these devices as effective luminous navigation signs for industrial ...
Hao Song, Liang Yi, Lixiang Huang, Wajid Ali, Linhan Cai, Chao Wang, Jianhua Huang, Ziwei Li, Anlian Pan   +8 more
wiley   +1 more source

2023–2027 CAP First Pillar Reform and Livestock Sector: Production and Economic Impacts on Italian Specialized Dairy Cattle Farms

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT The present study uses an agroeconomic supply model to assess the impacts of 2023–2027 CAP on Italian specialized dairy cattle farms. The model considers the voluntary choice of Eco‐Scheme 1, specifically addressed to livestock farms, through the implementation of binary variables.
Davide Dell'Unto, Raffaele Cortignani
wiley   +1 more source

Multisectoral Convergence of Food, Nutrition and Sanitation Programs for Child Health: Evidence From Country‐Level Programs in India

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT This paper underscores the critical role of multisectoral convergence in enhancing child health, particularly in addressing anemia, a micronutrient deficiency linked to both diet and sanitation. We explore how the integration of nationwide food and nutrition programs with sanitation initiatives impacts anemia in Indian children under three ...
Soumya Gupta, Payal Seth, Prabhu Pingali
wiley   +1 more source