Results 91 to 100 of about 9,230,509 (381)
ALS plasma biomarkers reveal neurofilament and pTau correlate with disease onset and progression
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objective We performed a pilot screen to assess the utility of the NULISA™ (Nucleic‐acid‐Linked Immuno‐Sandwich Assay) platform in the identification of amyotrophic lateral sclerosis (ALS) biomarkers. Methods Plasma from 86 individuals (48 ALS, 18 asymptomatic C9orf72 repeat expansion carriers (AsymC9), and 20 healthy controls) was analyzed ...
Eleanor V. Thomas +10 more
wiley +1 more source
Mapping the Genetic-Imaging-Clinical Pathway with Applications to Alzheimer's Disease [PDF]
arXiv, 2020 Alzheimer's disease is a progressive form of dementia that results in problems with memory, thinking, and behavior. It often starts with abnormal aggregation and deposition of beta amyloid and tau, followed by neuronal damage such as atrophy of the hippocampi, leading to Alzheimer's Disease (AD).
arxiv
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACTObjectiveCerebrospinal fluid (CSF) orexin‐A has been suggested to be a biomarker of Alzheimer disease (AD). In both cognitively unimpaired healthy older adults and individuals with symptomatic AD, CSF orexin‐A is positively associated with CSF Aβ42, p‐tau181, and total tau (t‐tau) concentrations.
Ruijin Lu +13 more
wiley +1 more source
NeuroImage: Clinical, 2019 NIA-AA diagnostic criteria include volumetric or visual rating measures of hippocampal atrophy (HA) as a diagnostic biomarker of Alzheimer's disease (AD).
Neus Falgàs +16 more
doaj
Clinical and biomarker changes in dominantly inherited Alzheimer's disease.
New England Journal of Medicine, 2012 BACKGROUND The order and magnitude of pathologic processes in Alzheimer's disease are not well understood, partly because the disease develops over many years.
R. Bateman +27 more
semanticscholar +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Certain frontotemporal lobar degeneration subtypes, including TDP‐A and B, can either occur sporadically or in association with specific genetic mutations. It is uncertain whether syndromic or imaging features previously associated with these patient groups are subtype or genotype specific.
Sean Coulborn +17 more
wiley +1 more source
Visualization of PS/γ-Secretase Activity in Living Cells
iScience, 2020 Summary: A change in Presenilin (PS)/γ-secretase activity is linked to essential biological events as well as to the progression of many diseases. However, not much is known about how PS/γ-secretase activity is spatiotemporally regulated in cells. One of
Masato Maesako +5 more
doaj
Preliminary Evidence -- Diagnosed Alzheimer's Disease But Not MCI Affects Working Memory Capacity - 0.7 of 2.7 Memory Slots is Lost [PDF]
arXiv, 2016 Recently it was shown explicitly that free recall consists of two stages: the first few recalls empty working memory (narrowly defined) and a second stage, a reactivation stage, concludes the recall (Tarnow, 2015). It was also shown that the serial position curve changes in mild Alzheimer's disease, lowered total recall and lessened primacy, are ...
arxiv
Early BMI Change, Cognitive Decline, and CSF AD Biomarkers Alterations in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the relationship of early BMI change with subsequent cognitive decline, CSF AD biomarkers alterations, and progression to dementia in patients with PD. Methods Study data were prospectively collected from the PPMI cohort. Weight/height data at enrollment and second‐year clinical visit were utilized to calculate BMI change.
Rui Zhong, Kezhong Zhang
wiley +1 more source
APOE ε4 and resting‐state functional connectivity in racially/ethnically diverse older adults
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020 Introduction Numerous neuroimaging studies demonstrated an association between the apolipoprotein E (APOE) ε4 allele and resting‐state functional connectivity (rsFC) of regions within the default mode network (DMN), both in healthy populations and ...
Indira C. Turney +8 more
doaj +1 more source