Results 61 to 70 of about 9,355,841 (357)

Association between BrainAGE and Alzheimer's disease biomarkers

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION The brain age gap estimation (BrainAGE) method uses a machine learning model to generate an age estimate from structural magnetic resonance imaging (MRI) scans. The goal was to study the association of brain age with Alzheimer's disease (AD)
Yousaf Abughofah, Rachael Deardorff, Aaron Vosmeier, Savannah Hottle, Jeffrey L. Dage, Desarae Dempsey, Liana G. Apostolova, Jared Brosch, David Clark, Martin Farlow, Tatiana Foroud, Sujuan Gao, Sophia Wang, Henrik Zetterberg, Kaj Blennow, Andrew J. Saykin, Shannon L. Risacher   +16 more
doaj   +1 more source

Predicting future clinical changes of MCI patients using longitudinal and multimodal biomarkers.

PLoS ONE, 2012
Accurate prediction of clinical changes of mild cognitive impairment (MCI) patients, including both qualitative change (i.e., conversion to Alzheimer's disease (AD)) and quantitative change (i.e., cognitive scores) at future time points, is important for
Daoqiang Zhang, Dinggang Shen, Alzheimer's Disease Neuroimaging Initiative   +2 more
doaj   +1 more source

Topographical distribution of Aβ predicts progression to dementia in Aβ positive mild cognitive impairment

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
Introduction Abnormal brain amyloid beta (Aβ) is typically assessed in vivo using global concentrations from cerebrospinal fluid and positron emission tomography (PET). However, it is unknown whether the assessment of the topographical distribution of Aβ
Tharick A. Pascoal, Joseph Therriault, Sulantha Mathotaarachchi, Min Su Kang, Monica Shin, Andrea L. Benedet, Mira Chamoun, Cecile Tissot, Firoza Lussier, Sara Mohaddes, Jean‐Paul Soucy, Gassan Massarweh, Serge Gauthier, Pedro Rosa‐Neto, for the Alzheimer's Disease Neuroimaging Initiative   +14 more
doaj   +1 more source

Pulse Pressure, White Matter Hyperintensities, and Cognition: Mediating Effects Across the Adult Lifespan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate whether pulse pressure or mean arterial pressure mediates the relationship between age and white matter hyperintensity load and to examine the mediating effect of white matter hyperintensities on cognition. Methods Demographic information, blood pressure, current medication lists, and Montreal Cognitive Assessment ...
Jade Hannan, Sarah Newman‐Norlund, Natalie Busby, Sarah C. Wilson, Roger Newman‐Norlund, Chris Rorden, Julius Fridriksson, Leonardo Bonilha, Nicholas Riccardi   +8 more
wiley   +1 more source

Cerebrovascular stiffness and flow dynamics in the presence of amyloid and tau biomarkers

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021
Introduction This work investigated the relationship between cerebrovascular disease (CVD) markers and Alzheimer's disease (AD) biomarkers of amyloid beta deposition, and neurofibrillary tau tangles in subjects spanning the AD clinical spectrum.
Leonardo A. Rivera‐Rivera, Laura Eisenmenger, Karly A. Cody, Thomas Reher, Tobey Betthauser, Robert V. Cadman, Howard A. Rowley, Cynthia M. Carlsson, Nathaniel A. Chin, Sterling C. Johnson, Kevin M. Johnson   +10 more
doaj   +1 more source

Active Seizures Predict Worse Instrumental Activities of Daily Living in Individuals With Normal Cognition and Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Cognitive disorders are common in older persons with seizures (PWS). Cognitive disorders are often associated with impaired Instrumental Activities of Daily Living (IADLs). However, the effects of seizures on IADLs remain unexplored.
Ifrah Zawar, Jaideep Kapur, Meghan M. Mattos, Carol Manning, Syeda Amrah Hashmi, Mark Quigg   +5 more
wiley   +1 more source

Mitochondrial dysfunction - the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-β toxicity

Alzheimer's Research & Therapy, 2011
The pathology of Alzheimer's disease (AD) is characterized by amyloid plaques (aggregates of amyloid-β (Aβ)) and neurofibrillary tangles (aggregates of tau) and is accompanied by mitochondrial dysfunction, but the mechanisms underlying this dysfunction ...
Anne Eckert, K. Schmitt, Jürgen Götz
semanticscholar   +1 more source

2020 Alzheimer's disease facts and figures

Alzheimer's & Dementia, 2020
This article describes the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality and morbidity, use and costs of care, and the overall impact on caregivers and society.

semanticscholar   +1 more source

Correlation Between Irisin and Cognitive Functions in Alzheimer Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The myokine irisin, a recent positive mediator of exercise in the brain, shows neuroprotective functions against Alzheimer's disease (AD). The association between irisin and cognition has never been explored in a biologically defined cohort of patients.
Patrizia Pignataro, Manuela Dicarlo, Chiara Zecca, Daniele Urso, Maria Teresa Dell'Abate, Davide Vilella, Francesco Borlizzi, Roberta Zerlotin, Angela Oranger, Graziana Colaianni, Silvia Colucci, Maria Grano, Giancarlo Logroscino   +12 more
wiley   +1 more source

Linkage analysis of multiplex Caribbean Hispanic families loaded for unexplained early‐onset cases identifies novel Alzheimer's disease loci

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018
Introduction Less than 10% of early‐onset Alzheimer's disease (EOAD) is explained by known mutations. Methods We conducted genetic linkage analysis of 68 well‐phenotyped Caribbean Hispanic families without clear inheritance patterns or mutations in APP ...
Rong Cheng, Min Tang, Izri Martinez, Temitope Ayodele, Penelope Baez, Dolly Reyes‐Dumeyer, Rafael Lantigua, Martin Medrano, Ivonne Jimenez‐Velazquez, Joseph H. Lee, Gary W. Beecham, Christiane Reitz   +11 more
doaj   +1 more source