Results 61 to 70 of about 9,230,509 (381)

Disclosure of preclinical Alzheimer's disease biomarker results in research and clinical settings: Why, how, and what we still need to know

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021
Disclosure of personal disease‐related information to asymptomatic adults has been debated over the last century in medicine and research. Recently, Alzheimer's disease (AD) has been conceptualized as a continuum that begins with a “preclinical” stage in
Claire M. Erickson, Nathaniel A. Chin, Sterling C. Johnson, Carey E. Gleason, Lindsay R. Clark   +4 more
doaj   +1 more source

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

Treatments in Alzheimer’s disease [PDF]

Journal of Neurology, 2017
Alzheimer’s disease (AD) is the commonest cause of dementia worldwide. However, no treatment is yet available to halt or reverse the underlying pathology of established disease. Advances in the management of other common diseases and an improvement in general health have resulted in an increasingly elderly population so that the prevalence of AD is ...
Gauhar Abbas Malik, Neil Robertson
openaire   +4 more sources

Predicting future clinical changes of MCI patients using longitudinal and multimodal biomarkers.

PLoS ONE, 2012
Accurate prediction of clinical changes of mild cognitive impairment (MCI) patients, including both qualitative change (i.e., conversion to Alzheimer's disease (AD)) and quantitative change (i.e., cognitive scores) at future time points, is important for
Daoqiang Zhang, Dinggang Shen, Alzheimer's Disease Neuroimaging Initiative   +2 more
doaj   +1 more source

High Glycemic Diet Is Related to Brain Amyloid Accumulation Over One Year in Preclinical Alzheimer's Disease

Frontiers in Nutrition, 2021
Objective: To test the hypothesis that high glycemic diet is related to 1-year change in brain amyloid based on our prior cross-sectional evidence that high glycemic diet is associated with brain amyloid.Methods: This longitudinal, observational study ...
Matthew K. Taylor, Matthew K. Taylor, Debra K. Sullivan, Debra K. Sullivan, Jill K. Morris, Jill K. Morris, Eric D. Vidoni, Eric D. Vidoni, Robyn A. Honea, Robyn A. Honea, Jonathan D. Mahnken, Jonathan D. Mahnken, Jeffrey M. Burns, Jeffrey M. Burns   +13 more
doaj   +1 more source

Comprehensive Review on Alzheimer’s Disease: Causes and Treatment

Molecules, 2020
Alzheimer’s disease (AD) is a disorder that causes degeneration of the cells in the brain and it is the main cause of dementia, which is characterized by a decline in thinking and independence in personal daily activities.
Zeinab Breijyeh, R. Karaman
semanticscholar   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Alzheimer's Disease and Anesthesia [PDF]

Frontiers in Neuroscience, 2011
Cognitive disorders such as postoperative cognitive dysfunction, confusion, and delirium, are common following anesthesia in the elderly, with symptoms persisting for months or years in some patients. Alzheimer's disease (AD) patients appear to be particularly at risk of cognitive deterioration following anesthesia, and some studies suggest that ...
Emmanuel Planel, Marie-Amélie Papon, Noura B. El-Khoury, Robert A. Whittington   +3 more
openaire   +4 more sources

Cardiorespiratory fitness mitigates brain atrophy and cognitive decline in adults at risk for Alzheimer's disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021
Introduction Cardiorespiratory fitness (CRF) may mitigate Alzheimer's disease (AD) progression. This study examined the longitudinal associations of CRF with brain atrophy and cognitive decline in a late‐middle‐aged cohort of adults at risk for AD ...
Ryan J. Dougherty, Erin M. Jonaitis, Julian M. Gaitán, Sarah R. Lose, Brandon M. Mergen, Sterling C. Johnson, Ozioma C. Okonkwo, Dane B. Cook   +7 more
doaj   +1 more source

A reproducible 3D convolutional neural network with dual attention module (3D-DAM) for Alzheimer's disease classification [PDF]

arXiv, 2023
Alzheimer's disease is one of the most common types of neurodegenerative disease, characterized by the accumulation of amyloid-beta plaque and tau tangles. Recently, deep learning approaches have shown promise in Alzheimer's disease diagnosis. In this study, we propose a reproducible model that utilizes a 3D convolutional neural network with a dual ...
arxiv