Results 1 to 10 of about 9,392,963 (368)

2023 Alzheimer's disease facts and figures

open access: yesAlzheimer's & Dementia, 2023
This article describes the public health impact of Alzheimer's disease, including prevalence and incidence, mortality and morbidity, use and costs of care, and the overall impact on family caregivers, the dementia workforce and society.

semanticscholar   +1 more source

Lecanemab in Early Alzheimer's Disease.

open access: yesNew England Journal of Medicine, 2022
BACKGROUND The accumulation of soluble and insoluble aggregated amyloid-beta (Aβ) may initiate or potentiate pathologic processes in Alzheimer's disease.
C. V. van Dyck   +18 more
semanticscholar   +1 more source

Dissecting the human leptomeninges at single-cell resolution

open access: yesNature Communications, 2023
Emerging evidence shows that the meninges conduct essential immune surveillance and immune defense at the brain border, and the dysfunction of meningeal immunity contributes to aging and neurodegeneration.
Nicola A. Kearns   +8 more
doaj   +1 more source

Explainable deep learning approach for extracting cognitive features from hand-drawn images of intersecting pentagons

open access: yesnpj Digital Medicine, 2023
Hand drawing, which requires multiple neural systems for planning and controlling sequential movements, is a useful cognitive test for older adults.
Shinya Tasaki   +6 more
doaj   +1 more source

The association of Lewy bodies with limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes and their role in cognition and Alzheimer’s dementia in older persons

open access: yesActa Neuropathologica Communications, 2021
Lewy bodies (LBs) and limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) are common in older persons and associated with cognitive impairment.
Sonal Agrawal   +6 more
doaj   +1 more source

Inferring protein expression changes from mRNA in Alzheimer’s dementia using deep neural networks

open access: yesNature Communications, 2022
Protein changes in a brain with Alzheimer’s are not often accompanied by transcriptional differences. Here, using a deep neural network that predicts protein abundance from mRNA expression, the authors track the early protein changes in Alzheimer’s ...
Shinya Tasaki   +8 more
doaj   +1 more source

Are There Any Cognitive and Behavioral Changes Potentially Related to Quarantine Due to the COVID-19 Pandemic in People with Mild Cognitive Impairment and AD Dementia? A Longitudinal Study

open access: yesBrain Sciences, 2021
The aim of the study was to examine potential cognitive, mood (depression and anxiety) and behavioral changes that may be related to the quarantine and the lockdown applied during the COVID-19 pandemic in Greek older adults with mild cognitive impairment
Marianna Tsatali   +20 more
doaj   +1 more source

Biomedicine and Informatics Model of Alzheimer’s disease [PDF]

open access: yesAmerican Journal of Biochemistry and Biotechnology, 2007
In a perspective of biomedicine and informatics, the mechanism of Alzheimer's, senile amnesia, or other aging-associated and cognitive impairment related diseases involve four important informative processing procedures: propagation, consolidation, retrieval and cognition, In this study, we systematically model the four procedures based on published ...
Chang-Hua Zou, Kang Cheng
openaire   +2 more sources

Multi-platform proteomic analysis of Alzheimer’s disease cerebrospinal fluid and plasma reveals network biomarkers associated with proteostasis and the matrisome

open access: yesAlzheimer’s Research & Therapy, 2022
Robust and accessible biomarkers that can capture the heterogeneity of Alzheimer’s disease and its diverse pathological processes are urgently needed. Here, we undertook an investigation of Alzheimer’s disease cerebrospinal fluid (CSF) and plasma from ...
Eric B. Dammer   +7 more
doaj   +1 more source

Cortical proteins may provide motor resilience in older adults

open access: yesScientific Reports, 2021
Motor resilience proteins may be a high value therapeutic target that offset the negative effects of pathologies on motor function. This study sought to identify cortical proteins associated with motor decline unexplained by brain pathologies that ...
Aron S. Buchman   +11 more
doaj   +1 more source

Home - About - Disclaimer - Privacy