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2023 Alzheimer's disease facts and figures
Alzheimer's & Dementia, 2023 This article describes the public health impact of Alzheimer's disease, including prevalence and incidence, mortality and morbidity, use and costs of care, and the overall impact on family caregivers, the dementia workforce and society.
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Lecanemab in Early Alzheimer's Disease.
New England Journal of Medicine, 2022 BACKGROUND The accumulation of soluble and insoluble aggregated amyloid-beta (Aβ) may initiate or potentiate pathologic processes in Alzheimer's disease.
C. V. van Dyck +18 more
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Dissecting the human leptomeninges at single-cell resolution
Nature Communications, 2023 Emerging evidence shows that the meninges conduct essential immune surveillance and immune defense at the brain border, and the dysfunction of meningeal immunity contributes to aging and neurodegeneration.
Nicola A. Kearns +8 more
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npj Digital Medicine, 2023 Hand drawing, which requires multiple neural systems for planning and controlling sequential movements, is a useful cognitive test for older adults.
Shinya Tasaki +6 more
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Acta Neuropathologica Communications, 2021 Lewy bodies (LBs) and limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) are common in older persons and associated with cognitive impairment.
Sonal Agrawal +6 more
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Inferring protein expression changes from mRNA in Alzheimer’s dementia using deep neural networks
Nature Communications, 2022 Protein changes in a brain with Alzheimer’s are not often accompanied by transcriptional differences. Here, using a deep neural network that predicts protein abundance from mRNA expression, the authors track the early protein changes in Alzheimer’s ...
Shinya Tasaki +8 more
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Brain Sciences, 2021 The aim of the study was to examine potential cognitive, mood (depression and anxiety) and behavioral changes that may be related to the quarantine and the lockdown applied during the COVID-19 pandemic in Greek older adults with mild cognitive impairment
Marianna Tsatali +20 more
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Biomedicine and Informatics Model of Alzheimer’s disease [PDF]
American Journal of Biochemistry and Biotechnology, 2007 In a perspective of biomedicine and informatics, the mechanism of Alzheimer's, senile amnesia, or other aging-associated and cognitive impairment related diseases involve four important informative processing procedures: propagation, consolidation, retrieval and cognition, In this study, we systematically model the four procedures based on published ...
Chang-Hua Zou, Kang Cheng
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Alzheimer’s Research & Therapy, 2022 Robust and accessible biomarkers that can capture the heterogeneity of Alzheimer’s disease and its diverse pathological processes are urgently needed. Here, we undertook an investigation of Alzheimer’s disease cerebrospinal fluid (CSF) and plasma from ...
Eric B. Dammer +7 more
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Cortical proteins may provide motor resilience in older adults
Scientific Reports, 2021 Motor resilience proteins may be a high value therapeutic target that offset the negative effects of pathologies on motor function. This study sought to identify cortical proteins associated with motor decline unexplained by brain pathologies that ...
Aron S. Buchman +11 more
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