Results 91 to 100 of about 672,318 (344)

Serum Neurofilament Light Chain in Multiple Sclerosis: Superiority of Age‐ and BMI‐Corrected Z Scores/Percentiles Over Absolute Cutoff Values for Prediction of Treatment Response

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Prognostication of disease course and prediction of treatment response in multiple sclerosis is an unmet need. We compared the performance of serum neurofilament light chain Z scores (age‐ and BMI‐adjusted) with absolute concentrations for the prediction of response to disease‐modifying therapy.
Maximilian Einsiedler, Aleksandra Maleska Maceski, Sofia Sandgren, Johanna Oechtering, Sabine Schaedelin, Lisa Hofer, Amar Zadic, Juan Francisco Vilchez Gomez, Lester Melie‐Garcia, Alessandro Cagol, Riccardo Galbusera, Sebastian Finkener, Patrice Lalive, Marjolaine Uginet, Stefanie Müller, Caroline Pot, Amandine Mathias, Renaud Du Pasquier, Robert Hoepner, Andrew Chan, Giulio Disanto, Chiara Zecca, Marcus D’Souza, Lars G. Hemkens, Tobias Derfuss, Özgür Yaldizli, Patrick Roth, Claudio Gobbi, David Brassat, Björn Tackenberg, Henrik Zetterberg, Tjalf Ziemssen, Heinz Wiendl, Klaus Berger, Marco Hermesdorf, Fredrik Piehl, Ludwig Kappos, Cristina Granziera, Ahmed Abdelhak, David Leppert, Eline A. J. Willemse, Pascal Benkert, Jens Kuhle, Swiss Multiple Sclerosis Cohort Study (SMSC)   +43 more
wiley   +1 more source

Leveraging football accelerometer data to quantify associations between repetitive head impacts and chronic traumatic encephalopathy in males

Nature Communications, 2023
Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head impacts (RHI), but the components of RHI exposure underlying this relationship are unclear.
Daniel H. Daneshvar, Evan S. Nair, Zachary H. Baucom, Abigail Rasch, Bobak Abdolmohammadi, Madeline Uretsky, Nicole Saltiel, Arsal Shah, Johnny Jarnagin, Christine M. Baugh, Brett M. Martin, Joseph N. Palmisano, Jonathan D. Cherry, Victor E. Alvarez, Bertrand R. Huber, Jennifer Weuve, Christopher J. Nowinski, Robert C. Cantu, Ross D. Zafonte, Brigid Dwyer, John F. Crary, Lee E. Goldstein, Neil W. Kowall, Douglas I. Katz, Robert A. Stern, Yorghos Tripodis, Thor D. Stein, Michael D. McClean, Michael L. Alosco, Ann C. McKee, Jesse Mez   +30 more
doaj   +1 more source

The impact of dementia, age and sex on category fluency: Greater deficits in women with Alzheimer's disease [PDF]

, 2008
Original article can be found at: http://www.sciencedirect.com/science/journal/00109452 Copyright Elsevier Masson DOI: 10.1016/j.cortex.2007.11.008A category specific effect in naming tasks has been reported in patients with Alzheimer's dementia ...
Laws, K.R., Moreno-Martinez, F.J., Schulz, J.   +2 more
core   +1 more source

MOESM1 of Patterns of Chinese medicine use in prescriptions for treating Alzheimerâ s disease in Taiwan

, 2016
Additional file 1. The approval Letter from Taipei City Hospital Institutional Review Board.
Shun-Ku Lin, Sui-Hing Yan, Jung-Nien Lai, Tung-Hu Tsai   +3 more
openaire   +1 more source

Cytokine, Chemokine, and Neurofilament Light Chain Signatures in LGI1 Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate the value of cytokine, chemokine, and neurofilament light chain (NfL) concentrations in predicting relapse risk, chronic epilepsy, and functional impairment in LGI1 autoimmune encephalitis (AE). Methods Cytokines/chemokines (IL‐1‐beta, IL‐2, IL‐4, IL‐5, IL‐6, IL‐8/CXCL8, IL‐10, IL‐12p70, IL‐13, IL‐17A, GM‐CSF, TNF ...
Albert Aboseif, Georgios Mangioris, Binxia Yang, Vanessa K. Pazdernik, Jeffrey W. Britton, Divyanshu Dubey, Eoin P. Flanagan, Sarosh R. Irani, Gregory S. Day, Charles L. Howe, A. Sebastian López‐Chiriboga, Andrew McKeon, John R. Mills, Yahel Segal, Michel Toledano, Ivana Vodopivec, Sean J. Pittock, Anastasia Zekeridou   +17 more
wiley   +1 more source

Retinal biomarkers of Alzheimer’s disease: insights from transgenic mouse models [PDF]

, 2017
In this paper, we use the retina as a window into the central nervous system and in particular to assess changes in the retinal tissue associated with the Alzheimer’s disease.
Ambrósio, António F., Bernardes, Rui, Chiquita, Samuel, Serranho, Pedro, Silva, Gilberto   +4 more
core   +1 more source

AlzheimerÂ’s Disease, Cerebrovascular Disease and Dementia: A Potentially Preventable and Modifiable Syndrome

Journal of Alzheimer’s Disease & Parkinsonism, 2015
Alzheimer’s disease (AD) and cerebrovascular disease (CVD) frequently co-exist and are part of a syndrome that may result in ageing-related cognitive impairment and dementia. Somemen and women with the neurodegenerative and cerebrovascular changes associated with dementia have normal cognition ascribed to a high cognitive reserve or resilience.
openaire   +3 more sources

Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice

Translational Psychiatry, 2022
Apolipoprotein E ε4 (APOE4) is the primary genetic risk factor for the late-onset form of Alzheimer’s disease (AD). Although the reason for this association is not completely understood, researchers have uncovered numerous effects of APOE4 expression on ...
André Miguel Miranda, Archana Ashok, Robin Barry Chan, Bowen Zhou, Yimeng Xu, Laura Beth McIntire, Estela Area-Gomez, Gilbert Di Paolo, Karen E. Duff, Tiago Gil Oliveira, Tal Nuriel   +10 more
doaj   +1 more source

Speaking with Barry Rovner, MD [PDF]

, 2009
Q: What Alzheimer’s related studies are you involved in currently at the Farber Institute for Neurosciences? Dr. Rovner: We are evaluating three exciting new disease-modifying drug treatments that may slow down the course of Alzheimer’s disease.

core   +1 more source

MOESM2 of Patterns of Chinese medicine use in prescriptions for treating Alzheimerâ s disease in Taiwan

, 2016
Additional file 2. The approval Letter from National Institutes of Health.
Shun-Ku Lin, Sui-Hing Yan, Jung-Nien Lai, Tung-Hu Tsai   +3 more
openaire   +1 more source