Results 11 to 20 of about 9,943,375 (345)

A Longitudinal Study of Acculturation in Context and Cardiovascular Health and Their Effects on Cognition Among Older Latino Adults

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background We previously outlined the importance of considering acculturation within the context of older Latino adults' lived experience (ie, acculturation in context) to better capture contributors to cognitive aging.
Melissa Lamar, Mayra L. Estrella, Ana W. Capuano, Sue Leurgans, Debra A. Fleischman, Lisa L. Barnes, Brittney S. Lange‐Maia, David A. Bennett, David X. Marquez   +8 more
doaj   +1 more source

Differential vulnerability of the dentate gyrus to tauopathies in dementias

Acta Neuropathologica Communications, 2023
The dentate gyrus (DG), a key hippocampal subregion in memory processing, generally resists phosphorylated tau accumulation in the amnestic dementia of the Alzheimer’s type due to Alzheimer’s disease (DAT-AD), but less is known about the susceptibility ...
Allegra Kawles, Grace Minogue, Antonia Zouridakis, Rachel Keszycki, Nathan Gill, Caren Nassif, Christina Coventry, Hui Zhang, Emily Rogalski, Margaret E. Flanagan, Rudolph Castellani, Eileen H. Bigio, M. Marsel Mesulam, Changiz Geula, Tamar Gefen   +14 more
doaj   +1 more source

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Nature Genetics, 2022
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes.
C. Bellenguez, Fahri Küçükali, I. Jansen, L. Kleineidam, S. Moreno-Grau, N. Amin, A. Naj, Rafael Campos-Martin, B. Grenier‐Boley, V. Andrade, P. Holmans, A. Boland, V. Damotte, S. J. van der Lee, M. R. Costa, T. Kuulasmaa, Qiong Yang, I. de Rojas, J. Bis, A. Yaqub, I. Prokić, J. Chapuis, S. Ahmad, V. Giedraitis, D. Aarsland, P. García-González, C. Abdelnour, E. Alarcón‐Martín, D. Alcolea, M. Alegret, I. Álvarez, V. Álvarez, N. Armstrong, A. Tsolaki, C. Antunez, I. Appollonio, M. Arcaro, S. Archetti, A. Pastor, B. Arosio, L. Athanasiu, H. Bailly, N. Banaj, M. Baquero, S. Barral, A. Beiser, A. Pastor, J. Below, Penelope H. Benchek, L. Benussi, C. Berr, C. Besse, Valentina Bessi, G. Binetti, Alessandra Bizarro, R. Blesa, M. Boada, E. Boerwinkle, B. Borroni, S. Boschi, P. Bossù, G. Bråthen, J. Bressler, Catherine Bresner, H. Brodaty, K. Brookes, L. Brusco, D. Buiza‐Rueda, K. Bûrger, V. Burholt, W. Bush, M. Calero, L. Cantwell, G. Chêne, Jaeyoon Chung, M. Cuccaro, Á. Carracedo, R. Cecchetti, Laura Cervera-Carles, C. Charbonnier, Hung-Hsin Chen, C. Chillotti, S. Ciccone, J. Claassen, C. Clark, E. Conti, A. Corma-Gómez, E. Costantini, C. Custodero, D. Daian, M. Dalmasso, A. Daniele, E. Dardiotis, J. Dartigues, P. D. de Deyn, Katia de Paiva Lopes, L. D. de Witte, S. Debette, J. Deckert, T. del Ser, N. Denning, A. Destefano, M. Dichgans, J. Diehl-Schmid, M. Diez-Fairen, P. Rossi, S. Djurovic, E. Duron, E. Düzel, C. Dufouil, G. Eiriksdottir, S. Engelborghs, V. Escott-Price, A. Espinosa, M. Ewers, K. Faber, Tagliavini Fabrizio, S. F. Nielsen, D. Fardo, L. Farotti, C. Fenoglio, M. Fernandez-Fuertes, R. Ferrari, Catarina B. Ferreira, E. Ferri, B. Fin, P. Fischer, T. Fladby, K. Fliessbach, Bernard Fongang, M. Fornage, J. Fortea, T. Foroud, Silvia Fostinelli, Nick C Fox, E. Franco-Macías, M. Bullido, A. Frank‐García, L. Froelich, B. Fulton-Howard, D. Galimberti, J. M. García-Alberca, P. García-González, S. García-Madrona, G. García-Ribas, R. Ghidoni, I. Giegling, Giaccone Giorgio, A. Goate, O. Goldhardt, Duber Gomez-Fonseca, A. Gonzáléz-Pérez, C. Graff, G. Grande, E. Green, T. Grimmer, E. Grünblatt, M. Grunin, V. Gudnason, Tamar Guetta‐Baranés, A. Haapasalo, G. Hadjigeorgiou, J. Haines, K. Hamilton-Nelson, H. Hampel, O. Hanon, J. Hardy, A. Hartmann, L. Hausner, J. Harwood, S. Heilmann-Heimbach, S. Helisalmi, M. Heneka, I. Hernández, M. Herrmann, P. Hoffmann, C. Holmes, H. Holstege, Raquel Huerto Vilas, M. Hulsman, J. Humphrey, G. Biessels, X. Jian, C. Johansson, G. Jun, Y. Kastumata, J. Kauwe, P. Kehoe, L. Kilander, A. Ståhlbom, M. Kivipelto, A. Koivisto, J. Kornhuber, M. Kosmidis, W. Kukull, Pavel P. Kuksa, B. Kunkle, A. Kuzma, C. Lage, E. Laukka, L. Launer, A. Lauria, Chien-Yueh Lee, J. Lehtisalo, O. Lerch, A. Lleó, W. Longstreth, O. Lopez, A. L. de Munain, S. Love, Malin Löwemark, L. Luckcuck, K. Lunetta, Yiyi Ma, J. Macías, C. MacLeod, W. Maier, F. Mangialasche, M. Spallazzi, M. Marquié, R. Marshall, E. R. Martin, Angel Martin Montes, Carmen Martínez Rodríguez, C. Masullo, R. Mayeux, S. Mead, P. Mecocci, M. Medina, A. Meggy, S. Mehrabian, S. Mendoza, M. Menéndez-González, P. Mir, S. Moebus, M. Mol, L. Molina-Porcel, L. Montrreal, L. Morelli, F. Moreno, K. Morgan, T. Mosley, M. Nöthen, C. Muchnik, S. Mukherjee, B. Nacmias, T. Ngandu, G. Nicolas, B. Nordestgaard, R. Olaso, A. Orellana, Michela Orsini, G. Ortega, A. Padovani, Caffarra Paolo, G. Papenberg, L. Parnetti, F. Pasquier, P. Pastor, G. Peloso, A. Pérez-Cordón, J. Pérez-Tur, Pierre Pericard, O. Peters, Y. Pijnenburg, J. Pineda, G. Piñol-Ripoll, C. Pisanu, T. Polak, J. Popp, D. Posthuma, J. Priller, R. Puerta, O. Quenez, I. Quintela, J. Thomassen, A. Rábano, I. Rainero, F. Rajabli, I. Ramakers, L. Real, M. Reinders, C. Reitz, D. Reyes-Dumeyer, P. Ridge, S. Riedel-Heller, P. Riederer, N. Roberto, E. Rodríguez-Rodríguez, A. Rongve, I. Allende, M. Rosende-Roca, J. Royo, E. Rubino, D. Rujescu, M. Sáez, P. Sakka, I. Saltvedt, Á. Sanabria, M. B. Sánchez-Arjona, F. Sánchez-García, P. S. Juan, R. Sánchez-Valle, S. Sando, C. Sarnowski, C. Satizabal, M. Scamosci, N. Scarmeas, E. Scarpini, P. Scheltens, N. Scherbaum, M. Scherer, M. Schmid, A. Schneider, J. Schott, G. Selbæk, D. Seripa, M. Serrano, Jin Sha, A. Shadrin, O. Skrobot, S. Slifer, G. Snijders, H. Soininen, V. Solfrizzi, A. Solomon, Yeunjoo E. Song, S. Sorbi, O. Sotolongo-Grau, G. Spalletta, A. Spottke, A. Squassina, E. Stordal, Juan Pablo Tartan, L. Tárraga, N. Tesi, A. Thalamuthu, Tegos Thomas, G. Tosto, L. Traykov, L. Tremolizzo, A. Tybjærg-Hansen, A. Uitterlinden, Abbe Ullgren, I. Ulstein, S. Valero, O. Valladares, C. Broeckhoven, J. Vance, B. Vardarajan, A. van der Lugt, Jasper Van Dongen, J. V. van Rooij, J. V. van Swieten, R. Vandenberghe, F. Verhey, J. Vidal, Jonathan S. Vogelgsang, M. Vyhnálek, Michael Wagner, D. Wallon, Li-San Wang, Ruiqi Wang, L. Weinhold, J. Wiltfang, Gill Windle, B. Woods, M. Yannakoulia, Habil Zare, Yi Zhao, Xiaoling Zhang, Congcong Zhu, M. Zulaica, L. Farrer, B. Psaty, M. Ghanbari, T. Raj, P. Sachdev, K. Mather, F. Jessen, M. A. Ikram, A. de Mendonça, J. Hort, M. Tsolaki, M. Pericak-Vance, P. Amouyel, Julie Williams, R. Frikke-Schmidt, J. Clarimón, J. Deleuze, G. Rossi, S. Seshadri, O. Andreassen, M. Ingelsson, M. Hiltunen, K. Sleegers, G. Schellenberg, C. V. van Duijn, R. Sims, W. M. van der Flier, A. Ruiz, A. Ramírez, J. Lambert   +402 more
semanticscholar   +1 more source

Assessment of Screening Approach in Early and Differential Alzheimer’s Disease Diagnosis

Antioxidants, 2021
Background: Alzheimer’s disease (AD) is the leading cause of dementia in the elderly population. Currently, diagnosis is based on invasive and expensive techniques, so there is a growing need to look for other possible tests, as well as carry out ...
Laura Ferré-González, Carmen Peña-Bautista, Lourdes Álvarez-Sánchez, Inés Ferrer-Cairols, Miguel Baquero, Consuelo Cháfer-Pericás   +5 more
doaj   +1 more source

Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer’s disease [PDF]

, 2019
Alzheimer’s disease currently lacks treatment options that effectively reverse the biological/anatomical pathology and cognitive deficits associated with the disease.
Burris, Thomas P, Farr, Susan A, Kermath, Bailey A, Morley, John E, Musiek, Erik S, Niehoff, Michael, Roby, Deborah A, Ruiz, Fernanda, Voorhees, Jaymie R, Zhang, Jinsong   +9 more
core   +3 more sources

Alzheimer’s disease frequency peaks in the tenth decade and is lower afterwards

Acta Neuropathologica Communications, 2019
Age is the most robust risk factor for Alzheimer’s dementia, however there is little data on the relation of age to Alzheimer’s disease (AD) and other common neuropathologies that contribute to Alzheimer’s dementia.
Jose M. Farfel, Lei Yu, Patricia A. Boyle, Sue Leurgans, Raj C. Shah, Julie A. Schneider, David A. Bennett   +6 more
doaj   +1 more source

Nuclear dynamics and stress responses in Alzheimer’s disease

Molecular Neurodegeneration, 2021
In response to extracellular and intracellular stressors, the nucleus and nuclear compartments undergo distinct molecular changes to maintain cell homeostasis.
Artemis Iatrou, Eric M. Clark, Yanling Wang   +2 more
doaj   +1 more source

The amyloid hypothesis of Alzheimer's disease at 25 years

EMBO Molecular Medicine, 2016
Despite continuing debate about the amyloid β‐protein (or Aβ hypothesis, new lines of evidence from laboratories and clinics worldwide support the concept that an imbalance between production and clearance of Aβ42 and related Aβ peptides is a very early,
D. Selkoe, J. Hardy
semanticscholar   +1 more source

The Assessment of Behavioural Decline in Adults with Down's Syndrome [PDF]

, 2007
The present study examines two methods of using the Vineland Adaptive Behaviour Scales as a measure of behavioural change in people with Down syndrome who are at risk of developing Alzheimer’s disease.
Harte, Cyan, Matheson, Edith, McKenzie, Karen, Murray, George, Patrick, Shona   +4 more
core   +1 more source

A Novel Joint Brain Network Analysis Using Longitudinal Alzheimer's Disease Data. [PDF]

, 2019
There is well-documented evidence of brain network differences between individuals with Alzheimer's disease (AD) and healthy controls (HC). To date, imaging studies investigating brain networks in these populations have typically been cross-sectional ...
Alzheimer’s Disease Neuroimaging Initiative, Galvin, James, Guo, Ying, Kundu, Suprateek, Lukemire, Joshua, Wang, Yikai   +5 more
core   +2 more sources