Results 31 to 40 of about 9,392,963 (368)

New insights into the genetic etiology of Alzheimer’s disease and related dementias

open access: yesNature Genetics, 2022
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes.
C. Bellenguez   +402 more
semanticscholar   +1 more source

Longitudinal chemokine profile expression in a blood-brain barrier model from Alzheimer transgenic versus wild-type mice

open access: yesJournal of Neuroinflammation, 2018
Background Alzheimer’s disease is widely described since the discovery of histopathological lesions in Mrs. Auguste Deter in 1906. However to date, there is no effective treatment to deal with the many cellular and molecular alterations.
J. Vérité   +5 more
doaj   +1 more source

Transcriptome analyses of 7-day-old zebrafish larvae possessing a familial Alzheimer’s disease-like mutation in psen1 indicate effects on oxidative phosphorylation, ECM and MCM functions, and iron homeostasis

open access: yesBMC Genomics, 2021
Background Early-onset familial Alzheimer’s disease (EOfAD) is promoted by dominant mutations, enabling the study of Alzheimer’s disease (AD) pathogenic mechanisms through generation of EOfAD-like mutations in animal models.
Yang Dong   +5 more
doaj   +1 more source

Herpes Simplex Virus Linked to AlzheimerÂ’s Disease [PDF]

open access: yesJournal of Tropical Diseases, 2013
Copyright: © 2013 Cheng SB. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
openaire   +2 more sources

Brain insulin signaling and cerebrovascular disease in human postmortem brain

open access: yesActa Neuropathologica Communications, 2021
Insulin is an important hormone for brain function, and alterations in insulin metabolism may be associated with neuropathology. We examined associations of molecular markers of brain insulin signaling with cerebrovascular disease.
Zoe Arvanitakis   +7 more
doaj   +1 more source

Diverse Roles of Ceramide in the Progression and Pathogenesis of Alzheimer’s Disease

open access: yesBiomedicines, 2022
Alzheimer’s disease (AD) is the most common neurodegenerative disorder, and is associated with several pathophysiological features, including cellular dysfunction, failure of neurotransmission, cognitive impairment, cell death, and other clinical ...
Md Riad Chowdhury   +2 more
doaj   +1 more source

Additional file 2: of The neuropathological diagnosis of Alzheimerâ s disease

open access: yes, 2019
Figure S2. Clinical Diagnoses of 227 Patients with a Pathologic Diagnosis of Pure AD. More than a third of pathologic AD cases on the Mayo Clinic Brain Bank from 2007 to 2016 were not expected to have AD. (PPTX 52 kb)
DeTure, Michael, Dickson, Dennis
openaire   +1 more source

Comprehensive Review on Alzheimer’s Disease: Causes and Treatment

open access: yesMolecules, 2020
Alzheimer’s disease (AD) is a disorder that causes degeneration of the cells in the brain and it is the main cause of dementia, which is characterized by a decline in thinking and independence in personal daily activities.
Zeinab Breijyeh, R. Karaman
semanticscholar   +1 more source

Atherosclerosis and Hippocampal Volumes in Older Adults: The Role of Age and Blood Pressure

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Lower hippocampal volume is associated with late‐life cognitive decline and is an important, but nonspecific marker for clinical Alzheimer's dementia. Cerebrovascular disease may also be associated with hippocampal volume.
Alifiya Kapasi   +7 more
doaj   +1 more source

BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice

open access: yesMolecular Neurodegeneration, 2018
Background β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting enzyme in the production of amyloid beta (Aβ), the toxic peptide that accumulates in the brains of Alzheimer’s disease (AD) patients.
WonHee Kim   +7 more
doaj   +1 more source

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