Results 81 to 90 of about 9,392,963 (368)

Clinical and biomarker changes in dominantly inherited Alzheimer's disease.

open access: yesNew England Journal of Medicine, 2012
BACKGROUND The order and magnitude of pathologic processes in Alzheimer's disease are not well understood, partly because the disease develops over many years.
R. Bateman   +27 more
semanticscholar   +1 more source

Precision‐Optimised Post‐Stroke Prognoses

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Current medicine cannot confidently predict who will recover from post‐stroke impairments. Researchers have sought to bridge this gap by treating the post‐stroke prognostic problem as a machine learning problem, reporting prediction error metrics across samples of patients whose outcomes are known.
Thomas M. H. Hope   +4 more
wiley   +1 more source

Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice

open access: yesTranslational Psychiatry, 2022
Apolipoprotein E ε4 (APOE4) is the primary genetic risk factor for the late-onset form of Alzheimer’s disease (AD). Although the reason for this association is not completely understood, researchers have uncovered numerous effects of APOE4 expression on ...
André Miguel Miranda   +10 more
doaj   +1 more source

Pulse Pressure, White Matter Hyperintensities, and Cognition: Mediating Effects Across the Adult Lifespan

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate whether pulse pressure or mean arterial pressure mediates the relationship between age and white matter hyperintensity load and to examine the mediating effect of white matter hyperintensities on cognition. Methods Demographic information, blood pressure, current medication lists, and Montreal Cognitive Assessment ...
Jade Hannan   +8 more
wiley   +1 more source

Variation in TMEM106B in chronic traumatic encephalopathy

open access: yesActa Neuropathologica Communications, 2018
The genetic basis of chronic traumatic encephalopathy (CTE) is poorly understood. Variation in transmembrane protein 106B (TMEM106B) has been associated with enhanced neuroinflammation during aging and with TDP-43-related neurodegenerative disease, and ...
Jonathan D. Cherry   +26 more
doaj   +1 more source

Additional file 4: of Beneficial effects of curtailing immune susceptibility in an Alzheimerâ s disease model

open access: yes, 2019
Figure S4. Co-localization of GITR and Foxp3 in the human AD brain. Immunofluorescence in representative samples for both molecules was detected in immune cells in the hippocampus of AD patients, whereas it was practically absent in the brain of healthy individuals (merge column; DAPIâ =â nuclear staining).
Benedetto, Giulia Di   +8 more
openaire   +1 more source

Active Seizures Predict Worse Instrumental Activities of Daily Living in Individuals With Normal Cognition and Dementia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Cognitive disorders are common in older persons with seizures (PWS). Cognitive disorders are often associated with impaired Instrumental Activities of Daily Living (IADLs). However, the effects of seizures on IADLs remain unexplored.
Ifrah Zawar   +5 more
wiley   +1 more source

Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade

open access: yesMolecular Neurodegeneration, 2019
Background Soluble aggregates of oligomeric forms of tau protein (oTau) have been associated with impairment of synaptic plasticity and memory in Alzheimer’s disease.
Erica Acquarone   +12 more
doaj   +1 more source

Additional file 1: of A phase III randomized trial of gantenerumab in prodromal Alzheimerâ s disease

open access: yes, 2017
List of institutional review boards and independent ethics committees. (DOCX 20 kb)
Ostrowitzki, Susanne   +16 more
openaire   +1 more source

Correlation Between Irisin and Cognitive Functions in Alzheimer Dementia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The myokine irisin, a recent positive mediator of exercise in the brain, shows neuroprotective functions against Alzheimer's disease (AD). The association between irisin and cognition has never been explored in a biologically defined cohort of patients.
Patrizia Pignataro   +12 more
wiley   +1 more source

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