Results 1 to 10 of about 2,538 (119)
BMJ Open, 2022 Objective Preventing Alzheimer’s dementia (AD) fundamentally equates to delaying onset. Thus, we quantified associations of modifiable, psychosocial risk factors to years of delayed onset of dementia.Design Two prospective cohorts (n=2860) with negative ...
Robert S Wilson +4 more
doaj +1 more source
IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2022 There are conventional screening instruments for the detection of cognitive impairment, but they have a reduced ecological validity and the information they present could be biased.
G. Palacios-Navarro +3 more
doaj +1 more source
Epidemiological Characteristics of Dementia and Its Correlation with Multimorbidity among Residents Aged 65 and Above [PDF]
Zhongguo quanke yixue, 2023 Background In the context of aging society in China, the prevalence of Alzheimer's disease increases and multimorbidity becomes more common with years. However, the extensive investigations of Alzheimer's disease in Hunan province have not been
ZHOU Sijing, LUO Bangan, CAO Hui, ZHANG Xi, WANG Dongxin
doaj +1 more source
Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology
EMBO Molecular Medicine, 2020 Polygenic risk scores have identified that genetic variants without genome‐wide significance still add to the genetic risk of developing Alzheimer's disease (AD). Whether and how subthreshold risk loci translate into relevant disease pathways is unknown.
Annerieke Sierksma +10 more
doaj +1 more source
A REVIEW OF BIOCHEMICAL MARKERS FOR EARLY DIAGNOSIS OF ALZHEIMERâS DISEASE [PDF]
American Journal of Neuroscience, 2012 Alzheimer’s disease, the most prevalent type of dementia, affects the life of elderly, to such extent that it impairs the ability to perform routine functions as well. The impairment of normal functions not only affects the patients but the family members as well.
openaire +1 more source
Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A
Neurobiology of Disease, 2008 The down-regulation of protein phosphatase 2A (PP2A) activity is thought to play an important role in the formation of tau hyperphosphorylation in the Alzheimer's disease (AD) brain. Methylation of the PP2A catalytic subunit at the L309 site can potently
Xin-Wen Zhou +6 more
doaj +1 more source
NeuroImage: Clinical, 2020 Introduction: Volumetric biomarkers for Alzheimer disease (AD) are attractive due to their wide availability and ease of administration, but have traditionally shown lower diagnostic accuracy than measures of neuropathological contributors to AD.
Lauren N. Koenig +16 more
doaj +1 more source
Dentistry Journal, 2019 Alzheimer’s disease is classified as a neurodegenerative condition, a heterogeneous group of illnesses characterized by the slow and progressive loss of one or more functions of the nervous system.
Mario Dioguardi +7 more
doaj +1 more source
Neural Regeneration Research, 2015 Alzheimer′s disease is a progressive neurodegenerative disorder, characterized by deposition of amyloid beta, neurofibrillary tangles, astrogliosis and microgliosis, leading to neuronal dysfunction and loss in the brain.
Madhuri Venigalla +3 more
doaj +1 more source
The effect of red grape juice on Alzheimer′s disease in rats
Advanced Biomedical Research, 2012 Background: Alzheimer′s disease is a neurodegenerative disease appearing as a result of free radicals and oxidative stress. Antioxidants agents boost memory and control Alzheimer′s disease.
Zahra Siahmard +3 more
doaj +1 more source