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Neuroinflammation in Alzheimer's disease [PDF]
The Lancet Neurology, 2015 Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astroglia, and trigger an innate immune response characterised by release ...
M. Heneka +41 more
semanticscholar +12 more sources
The Lancet, 2021 In this Seminar, we highlight the main developments in the field of Alzheimer's disease. The most recent data indicate that, by 2050, the prevalence of dementia will double in Europe and triple worldwide, and that estimate is 3 times higher when based on a biological (rather than clinical) definition of Alzheimer's disease.
Scheltens, P +7 more
openaire +4 more sources
eLife, 2020 To study the mechanisms by which the p.R47H variant of the microglia gene and Alzheimer’s disease (AD) risk factor TREM2 increases dementia risk, we created Trem2R47H KI rats.
Siqiang Ren +5 more
doaj +1 more source
Mapas de color: Un proyecto de intervención artística con personas con alzheimer y otras demencias.
Encuentros, 2022 Mapas de color, un mundo de memorias, es un proyecto de Arte y Salud (AR.S) financiado por la beca PIRTU de la Junta de Castilla y León y Fondo Social Europeo (ORDEN EDU/1204/2010, de 26 de Agosto), implementado en el Centro de Referencia Estatal de ...
Lorena López-Méndez
doaj +1 more source
The amyloid hypothesis of Alzheimer's disease at 25 years
EMBO Molecular Medicine, 2016 Despite continuing debate about the amyloid β‐protein (or Aβ hypothesis, new lines of evidence from laboratories and clinics worldwide support the concept that an imbalance between production and clearance of Aβ42 and related Aβ peptides is a very early,
D. Selkoe, J. Hardy
semanticscholar +1 more source
Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future
Signal Transduction and Targeted Therapy, 2023 Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer’s disease (AD), and its accumulation has been considered as the molecular driver of Alzheimer’s pathogenesis and progression.
Yun Zhang +4 more
semanticscholar +1 more source
Biomarkers in alzheimer’s dementia: health system and ageism
INFAD, 2020 The aging of the population in Spain is an issue that not only concerns the health of the population and Health, but also has important repercussions on the economy, family structure, sustainability of the pension system, etc.
Francisco Javier Balea Fernández +1 more
doaj +1 more source
Intervención psicológica familiar en la enfermedad de alzheimer
INFAD, 2020 La demencia es un síndrome adquirido, de naturaleza orgánica caracterizado por un deterioro permanente de la memoria y de otras funciones intelectuales, y frecuentemente acompañado de otros trastornos psiquiátricos, que ocurren sin alteración del nivel ...
Francisco Javier Balea Fernández +1 more
doaj +1 more source
Cold Spring Harbor Perspectives in Biology, 2011 Over the last three decades, advances in biochemical pathology and human genetics have illuminated one of the most enigmatic subjects in biomedicine--neurodegeneration.
D. Selkoe
semanticscholar +1 more source
Current Biology, 2006 On November 3rd 1906, the young doctor Alois Alzheimer delivers a talk in which he describes the psychiatric symptoms and changed brain histology of his late patient Auguste D. This moment marks the first publication of what was to become one of the most infamous afflictions, the disease that today bears his name: Alzheimer's disease.
openaire +3 more sources