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Insights into Alzheimer disease pathogenesis from studies in transgenic animal models [PDF]

Clinics, 2011
Alzheimer disease is the most common cause of dementia among the elderly, accounting for ~60-70% of all cases of dementia. The neuropathological hallmarks of Alzheimer disease are senile plaques (mainly containing p-amyloid peptide derived from amyloid ...
Evelin L. Schaeffer, Micheli Figueiro, Wagner F. Gattaz   +2 more
doaj   +7 more sources

Calcineurin inhibition may prevent Alzheimer disease in people with Down syndrome. [PDF]

Alzheimers Dement
Virtually all people with Down syndrome will develop Alzheimer disease pathology during their lifetime. As Alzheimer disease is the third leading cause of death and a significant factor in end-of-life complications for adults with Down syndrome ...
Dohl J, Treadwell Z, Norris C, Head E.
europepmc   +3 more sources

2023 Alzheimer's disease facts and figures

Alzheimer's & Dementia, 2023
This article describes the public health impact of Alzheimer's disease, including prevalence and incidence, mortality and morbidity, use and costs of care, and the overall impact on family caregivers, the dementia workforce and society.

semanticscholar   +1 more source

Modifiable psychosocial risk factors and delayed onset of dementia in older populations: analysis of two prospective US cohorts

BMJ Open, 2022
Objective Preventing Alzheimer’s dementia (AD) fundamentally equates to delaying onset. Thus, we quantified associations of modifiable, psychosocial risk factors to years of delayed onset of dementia.Design Two prospective cohorts (n=2860) with negative ...
Robert S Wilson, David A Bennett, Francine Grodstein, Tianhao Wang, Sue E. Leurgans   +4 more
doaj   +1 more source

Discriminant Validity of the WAIS-R Digit Symbol Substitution Test in Subjective Cognitive Decline, Mild Cognitive Impairment (Amnestic Subtype) and Alzheimer’s Disease Dementia (ADD) in Greece

Brain Sciences, 2021
Objective: The aim of the current study was to estimate the discriminant potential and validity of the Digit Symbol Substitution Test (DSST) of the WAIS-R in the Greek elderly population meeting criteria for subjective cognitive decline (SCD), mild ...
Marianna Tsatali, Eleni Poptsi, Despina Moraitou, Christina Agogiatou, Evaggelia Bakoglidou, Moses Gialaouzidis, Chrysa Papasozomenou, Aikaterini Soumpourou, Magdalini Tsolaki   +8 more
doaj   +1 more source

Lecanemab in Early Alzheimer's Disease.

New England Journal of Medicine, 2022
BACKGROUND The accumulation of soluble and insoluble aggregated amyloid-beta (Aβ) may initiate or potentiate pathologic processes in Alzheimer's disease.
C. V. van Dyck, C. Swanson, P. Aisen, R. Bateman, Christopher Chen, M. Gee, M. Kanekiyo, David Li, L. Reyderman, S. Cohen, L. Froelich, S. Katayama, M. Sabbagh, B. Vellas, David Watson, S. Dhadda, M. Irizarry, L. Kramer, T. Iwatsubo   +18 more
semanticscholar   +1 more source

Plasma microRNAs as potential biomarkers in early Alzheimer disease expression

Scientific Reports, 2022
The microRNAs (miRNAs) are potential biomarkers for complex pathologies due to their involvement in the regulation of several pathways. Alzheimer Disease (AD) requires new biomarkers in minimally invasive samples that allow an early diagnosis. The aim of
Carmen Peña-Bautista, Adrián Tarazona-Sánchez, Aitana Braza-Boils, Angel Balaguer, Laura Ferré-González, Antonio J. Cañada-Martínez, Miguel Baquero, Consuelo Cháfer-Pericás   +7 more
doaj   +1 more source

Emotional Function, Negative Thoughts about the Pandemic, and Adaptability Skills among Dementia Caregivers during the COVID-19 Pandemic

Brain Sciences, 2022
Background: It can be easily inferred that dementia caregivers were severely affected by the general home confinement, or ‘lockdown’, due to their caregiving roles.
Evdokia Nikolaidou, Marianna Tsatali, Marina Eleftheriou, Helen Wang, Konstantina Karagiozi, Petrina Margaritidou, Magdalini Tsolaki   +6 more
doaj   +1 more source

2021 Alzheimer's disease facts and figures

Alzheimer's & Dementia, 2021
This article describes the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality and morbidity, use and costs of care, and the overall impact on caregivers and society. The Special Report discusses the challenges
Anonymous
semanticscholar   +1 more source

GPS driving: a digital biomarker for preclinical Alzheimer disease

Alzheimer’s Research & Therapy, 2021
Background Alzheimer disease (AD) is the most common cause of dementia. Preclinical AD is the period during which early AD brain changes are present but cognitive symptoms have not yet manifest.
Sayeh Bayat, Ganesh M. Babulal, Suzanne E. Schindler, Anne M. Fagan, John C. Morris, Alex Mihailidis, Catherine M. Roe   +6 more
doaj   +1 more source