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Alzheimer’s disease [PDF]

Network: Computation in Neural Systems, 2011
Over the last three decades, advances in biochemical pathology and human genetics have illuminated one of the most enigmatic subjects in biomedicine--neurodegeneration. Eponymic diseases of the nervous system such as Alzheimer's, Parkinson's, and Huntington's diseases that were long characterized by mechanistic ignorance have yielded striking progress ...
Adam, Gazzaley, Scott A, Small
semanticscholar   +11 more sources

Modifiable psychosocial risk factors and delayed onset of dementia in older populations: analysis of two prospective US cohorts

BMJ Open, 2022
Objective Preventing Alzheimer’s dementia (AD) fundamentally equates to delaying onset. Thus, we quantified associations of modifiable, psychosocial risk factors to years of delayed onset of dementia.Design Two prospective cohorts (n=2860) with negative ...
Robert S Wilson, David A Bennett, Francine Grodstein, Tianhao Wang, Sue E. Leurgans   +4 more
doaj   +1 more source

Alzheimer's Disease [PDF]

Neurobiology of Disease, 2000
Use of valid diagnostic criteria is extremely important in the recognition of Alzheimer's disease (AD). Patients with mild to moderate Alzheimer's disease should be started on a cholinesterase inhibitor and possibly anti-inflammatory agents, antioxidants (vitamin E or selegiline), and estrogen replacement therapy (for postmenopausal women).
, Schachter, , Davis
  +8 more sources

Discriminant Validity of the WAIS-R Digit Symbol Substitution Test in Subjective Cognitive Decline, Mild Cognitive Impairment (Amnestic Subtype) and Alzheimer’s Disease Dementia (ADD) in Greece

Brain Sciences, 2021
Objective: The aim of the current study was to estimate the discriminant potential and validity of the Digit Symbol Substitution Test (DSST) of the WAIS-R in the Greek elderly population meeting criteria for subjective cognitive decline (SCD), mild ...
Marianna Tsatali, Eleni Poptsi, Despina Moraitou, Christina Agogiatou, Evaggelia Bakoglidou, Moses Gialaouzidis, Chrysa Papasozomenou, Aikaterini Soumpourou, Magdalini Tsolaki   +8 more
doaj   +1 more source

Plasma microRNAs as potential biomarkers in early Alzheimer disease expression

Scientific Reports, 2022
The microRNAs (miRNAs) are potential biomarkers for complex pathologies due to their involvement in the regulation of several pathways. Alzheimer Disease (AD) requires new biomarkers in minimally invasive samples that allow an early diagnosis. The aim of
Carmen Peña-Bautista, Adrián Tarazona-Sánchez, Aitana Braza-Boils, Angel Balaguer, Laura Ferré-González, Antonio J. Cañada-Martínez, Miguel Baquero, Consuelo Cháfer-Pericás   +7 more
doaj   +1 more source

Emotional Function, Negative Thoughts about the Pandemic, and Adaptability Skills among Dementia Caregivers during the COVID-19 Pandemic

Brain Sciences, 2022
Background: It can be easily inferred that dementia caregivers were severely affected by the general home confinement, or ‘lockdown’, due to their caregiving roles.
Evdokia Nikolaidou, Marianna Tsatali, Marina Eleftheriou, Helen Wang, Konstantina Karagiozi, Petrina Margaritidou, Magdalini Tsolaki   +6 more
doaj   +1 more source

Limited Substrate Specificity of PS/γ-Secretase Is Supported by Novel Multiplexed FRET Analysis in Live Cells

Biosensors, 2021
Presenilin (PS)/γ-secretase is an aspartyl protease that processes a wide range of transmembrane proteins such as the amyloid precursor protein (APP) and Notch1, playing essential roles in normal biological events and diseases.
Mei C. Q. Houser, Yuliia Turchyna, Florian Perrin, Lori Chibnik, Oksana Berezovska, Masato Maesako   +5 more
doaj   +1 more source

GPS driving: a digital biomarker for preclinical Alzheimer disease

Alzheimer’s Research & Therapy, 2021
Background Alzheimer disease (AD) is the most common cause of dementia. Preclinical AD is the period during which early AD brain changes are present but cognitive symptoms have not yet manifest.
Sayeh Bayat, Ganesh M. Babulal, Suzanne E. Schindler, Anne M. Fagan, John C. Morris, Alex Mihailidis, Catherine M. Roe   +6 more
doaj   +1 more source

Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders

Molecular Neurodegeneration, 2023
DNA sensing is a pivotal component of the innate immune system that is responsible for detecting mislocalized DNA and triggering downstream inflammatory pathways.
Yige Huang, Bangyan Liu, Subhash C. Sinha, Sadaf Amin, Li Gan   +4 more
doaj   +1 more source

Prescribing cholinesterase inhibitors in mild cognitive impairment—Observations from the Alzheimer's Disease Neuroimaging Initiative

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021
Introduction Analyses of off‐label use of acetylcholinesterase inhibitors (AChEIs) in mild cognitive impairment (MCI) has produced mixed results. Post hoc analyses of observational cohorts, such as the Alzheimer's Disease Neuroimaging Initiative (ADNI ...
Eddie Stage, Diana Svaldi, Sophie Sokolow, Shannon L. Risacher, Krisztina Marosi, Jerome I. Rotter, Andrew J. Saykin, Liana G. Apostolova, for the Alzheimer's Disease Neuroimaging Initiative   +8 more
doaj   +1 more source