Results 181 to 190 of about 9,708,599 (370)

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

Nature Reviews Neurology, 2018
Melanie D. Sweeney, A. Sagare, B. Zlokovic   +2 more
semanticscholar   +1 more source

A 3D Astrocyte Microenvironment Model Enables Rapid Ca2+‐Resolved Analysis and Therapeutic Modulation of Oxidative Neuroinflammation

Advanced Healthcare Materials, EarlyView.
This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim, Ye‐Ji Kim, Seyoung Ryu, Daeui Park, Kyoung‐Sik Moon, Yu Bin Lee, Dong Ho Woo   +6 more
wiley   +1 more source

P4‐296: DIFFERENTIAL NEUROCOGNITIVE NETWORK PERTURBATION IN TYPICAL AND ATYPICAL ALZHEIMER DISEASE [PDF]

, 2018
Adam Martersteck, Jaiashre Sridhar, Benjamin Rader, Todd B. Parrish, Marsel Mesulam, Emily Rogalskı   +5 more
openalex   +1 more source

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

Alzheimer's & Dementia, 2011
G. Mckhann, D. Knopman, H. Chertkow, B. Hyman, C. Jack, C. Kawas, W. Klunk, W. Koroshetz, J. Manly, R. Mayeux, R. Mohs, J. Morris, M. Rossor, P. Scheltens, M. Carrillo, B. Thies, S. Weintraub, C. Phelps   +17 more
semanticscholar   +1 more source

Human Brain Vasculature‐on‐a‐Chip Model Constructed With Microvessels Isolated From Cryopreserved Postmortem Human Brain Tissue

Advanced Healthcare Materials, EarlyView.
This manuscript describes the cultivation of viable microvessels from cryopreserved human brain tissue. When embedded in hydrogels and cultured in microfluidic devices, these microvessels exhibit complex architectures reminiscent of arterioles and capillaries, can be perfused, and display intact barrier function. Collectively, these results demonstrate
Brian J. O'Grady, A. Scott McCall, Samuel Cullison, Daniel Chavarria, Matthew S. Schrag, Ethan S. Lippmann   +5 more
wiley   +1 more source

Therapeutic effect of repetitive transcranial magnetic stimulation with cognitive training in mild to severe Alzheimer disease

, 2019
A. Lee, J. Lee, Eungseok Oh, Jungpil Shin, Eun Hee Sohn   +4 more
openalex   +2 more sources

Neuroinflammation in Alzheimer's disease

Lancet Neurology, 2015
M. Heneka, M. Carson, J. E. Khoury, G. Landreth, F. Brosseron, D. Feinstein, A. Jacobs, Tony Wyss-Coray, Tony Wyss-Coray, J. Vitorica, R. Ransohoff, K. Herrup, S. Frautschy, B. Finsen, Guy C. Brown, Alexei Verkhratsky, Alexei Verkhratsky, Alexei Verkhratsky, K. Yamanaka, J. Koistinaho, E. Latz, E. Latz, A. Halle, G. Petzold, T. Town, D. Morgan, M. Shinohara, V. Perry, Clive Holmes, Clive Holmes, N. Bazan, D. Brooks, S. Hunot, B. Joseph, N. Deigendesch, O. Garaschuk, E. Boddeke, C. Dinarello, J. Breitner, G. Cole, D. Golenbock, M. Kummer   +41 more
semanticscholar   +1 more source

The Space Within: How Architected Voids Promote Tissue Formation

Advanced Materials, EarlyView.
This review explores the role of void spaces in tissue engineering scaffolds and examines four key methods for introducing porosity into hydrogels at different scales. It discusses sacrificial templating, microgels, phase separation, and 3D printing, highlighting principles, advantages, and limitations. It also addresses emerging strategies integrating
Anna Puiggalí‐Jou, Isabel B. Hui, Carla Fernandez‐Rico, Marcy Zenobi‐Wong   +3 more
wiley   +1 more source

The Role of Chronic Stress as a Trigger for the Alzheimer Disease Continuum

Frontiers in Aging Neuroscience, 2020
Marina Ávila-Villanueva, Jaime Gómez-Ramírez, Fernando Maestú, Fernando Maestú, César Venero, Jesús Ávila, Jesús Ávila, Miguel A. Fernández-Blázquez   +7 more
doaj   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source