Comparison of Two Quantitative Methods for the Evaluation of Neuronal Number in the Frontal Cortex in Alzheimer Disease [PDF]
, 1997 IAN PAUL EVERALL +3 more
openalex +1 more source
Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD
Advanced Science, EarlyView.TDP‐43 dysfunction disrupts RNA processing, inducing cryptic exon 4a1 inclusion in GAP43 and reducing its protein levels. This aberrant splicing impairs axonal regeneration and contributes to neurodegeneration in ALS and AD. RNA‐seq of patient brains reveals GAP43 downregulation and 4a1 upregulation, identifying cryptic exon 4a1 as a potential ...
Mingming Yang +9 more
wiley +1 more source
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020 Mary Sano, Carolyn W. Zhu
doaj +1 more source
Identifying Families with Likely Genetic Protective Factors against Alzheimer Disease [PDF]
, 1999 Jeremy Silverman +6 more
openalex +1 more source
Revealing Cell‐Free Mitochondrial DNA Breakage Patterns as Novel Biomarkers for Sepsis
Advanced Science, EarlyView.Uncovering distinct plasma cfmtDNA breakage patterns opens new frontiers for early sepsis detection and prognosis. Unique cleavage hotspots in RNR2 and COX2 regions outperform traditional biomarkers, while mechanistic insights suggest bacterial endonuclease involvement.
Haitang Liao +13 more
wiley +1 more source
Network Desynchronization with Sine Waves: from Synchrony to Asynchrony by Periodic Stimulation
Advanced Science, EarlyView.Exogenous alternating current fields are explored and interact with cerebral cortex slow waves in vitro and in silico. Varying frequency and amplitude of sine waves result in distinct network dynamics, from phase‐locking and entrainment to desynchronization. These responses occupy specific regions within the parameter space.
Joana Covelo +4 more
wiley +1 more source
Loss of the Presynaptic Vesicle Protein Synaptophysin in Hippocampus Correlates with Cognitive Decline in Alzheimer Disease [PDF]
, 1997 Chun‐I Sze +5 more
openalex +1 more source
Dynein‐Dependent Endo‐Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology
Advanced Science, EarlyView.This study investigates the impact of Aβ plaques on α‐synuclein (αSyn) pathologies in dementia with Lewy bodies (DLB). Co‐culturing primary neurons with AD mouse brain slices reveals impaired dynein‐dependent organelle trafficking, affecting αSyn degradation. Activating Rab7 restores this process, reducing αSyn inclusions.
Linlin Zhou +14 more
wiley +1 more source
Risk of Developing Alzheimer Disease in Relation to Common Infections. [PDF]
Neurodegener DisCamacho-Soto A +6 more
europepmc +1 more source