Results 11 to 20 of about 9,181,201 (335)
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021 Introduction Analyses of off‐label use of acetylcholinesterase inhibitors (AChEIs) in mild cognitive impairment (MCI) has produced mixed results. Post hoc analyses of observational cohorts, such as the Alzheimer's Disease Neuroimaging Initiative (ADNI ...
Eddie Stage +8 more
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Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders
Molecular Neurodegeneration, 2023 DNA sensing is a pivotal component of the innate immune system that is responsible for detecting mislocalized DNA and triggering downstream inflammatory pathways.
Yige Huang +4 more
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The Importance of Advancing Research on Aging and Driving
Geriatrics, 2021 Between 2009 and 2018, the number of older adults (i [...]
Samantha A. Murphy +2 more
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Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future
Signal Transduction and Targeted Therapy, 2023 Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer’s disease (AD), and its accumulation has been considered as the molecular driver of Alzheimer’s pathogenesis and progression.
Yun Zhang +4 more
semanticscholar +1 more source
Pharmaceutics, 2023 (1) Background: The role of antihypertensives in Alzheimer’s Disease (AD) prevention is controversial. This case-control study aims to assess whether antihypertensive medication has a protective role by studying its association with amyloid and tau ...
Gemma García-Lluch +5 more
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Alzheimer’s Research & Therapy, 2021 Background Comprehensive testing of cognitive functioning is standard practice in studies of Alzheimer disease (AD). Short-form tests like the Montreal Cognitive Assessment (MoCA) use a “sampling” of measures, administering key items in a shortened ...
Jason Hassenstab +7 more
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TDP-43 pathology in anterior temporal pole cortex in aging and Alzheimer’s disease
Acta Neuropathologica Communications, 2018 TDP-43 pathology was investigated in the anterior temporal pole cortex (ATPC) and orbital frontal cortex (OFC), regions often degenerated in frontotemporal lobar degenerations (FTLD), in aging and Alzheimer’s disease (AD).
Sukriti Nag +5 more
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The amyloid hypothesis of Alzheimer's disease at 25 years
EMBO Molecular Medicine, 2016 Despite continuing debate about the amyloid β‐protein (or Aβ hypothesis, new lines of evidence from laboratories and clinics worldwide support the concept that an imbalance between production and clearance of Aβ42 and related Aβ peptides is a very early,
D. Selkoe, J. Hardy
semanticscholar +1 more source
A Novel NIR-FRET Biosensor for Reporting PS/γ-Secretase Activity in Live Cells
Sensors, 2020 Presenilin (PS)/γ-secretase plays a pivotal role in essential cellular events via proteolytic processing of transmembrane proteins that include APP and Notch receptors. However, how PS/γ-secretase activity is spatiotemporally regulated by other molecular
Mei CQ Houser +6 more
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In-Depth Characterization of Endo-Lysosomal Aβ in Intact Neurons
Biosensors, 2022 Amyloid-beta (Aβ) peptides are produced within neurons. Some peptides are released into the brain parenchyma, while others are retained inside the neurons. However, the detection of intracellular Aβ remains a challenge since antibodies against Aβ capture
Alec K. McKendell +5 more
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