Results 21 to 30 of about 317,693 (354)
A Novel NIR-FRET Biosensor for Reporting PS/γ-Secretase Activity in Live Cells
Sensors, 2020 Presenilin (PS)/γ-secretase plays a pivotal role in essential cellular events via proteolytic processing of transmembrane proteins that include APP and Notch receptors. However, how PS/γ-secretase activity is spatiotemporally regulated by other molecular
Mei CQ Houser +6 more
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In-Depth Characterization of Endo-Lysosomal Aβ in Intact Neurons
Biosensors, 2022 Amyloid-beta (Aβ) peptides are produced within neurons. Some peptides are released into the brain parenchyma, while others are retained inside the neurons. However, the detection of intracellular Aβ remains a challenge since antibodies against Aβ capture
Alec K. McKendell +5 more
doaj +1 more source
Optogenetic neuromodulation with gamma oscillation as a new strategy for Alzheimer disease: a narrative review [PDF]
Journal of Yeungnam Medical Science, 2022 The amyloid hypothesis has been considered a major explanation of the pathogenesis of Alzheimer disease. However, failure of phase III clinical trials with anti-amyloid-beta monoclonal antibodies reveals the need for other therapeutic approaches to treat
Haneol Ko, Sang-Pil Yoon
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Biomedicines, 2023 The role of metals in the pathogenesis of Alzheimer’s disease (AD) is still debated. Although previous research has linked changes in essential metal homeostasis and exposure to environmental heavy metals to the pathogenesis of AD, more research is needed to determine the relationship between metals and AD.
Mirjana Babić Leko +5 more
openaire +4 more sources
NETosis in Alzheimer’s Disease [PDF]
Frontiers in Immunology, 2017 Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the progressive deterioration of cognitive functions. Its neuropathological features include amyloid-β (Aβ) accumulation, the formation of neurofibrillary tangles, and the loss of neurons and synapses.
Pietronigro, Enrica Caterina +3 more
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Detection of tau in Gerstmann-Sträussler-Scheinker disease (PRNP F198S) by [18F]Flortaucipir PET
Acta Neuropathologica Communications, 2018 This study aimed to determine the pattern of [18F]flortaucipir uptake in individuals affected by Gerstmann-Sträussler-Scheinker disease (GSS) associated with the PRNP F198S mutation.
Shannon L. Risacher +11 more
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Microbes and Alzheimer’s Disease
Journal of Alzheimer's Disease, 2016 descripción no proporcionada por ...
Judith A. Whittum-Hudson +33 more
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On the reconceptualization of Alzheimer’s disease [PDF]
Bioethics, 2018 AbstractIn the hope of future treatments to prevent or slow down the disease, there is a strong movement towards an ever‐earlier detection of Alzheimer’s disease (AD). In conjunction with scientific developments, this has prompted a reconceptualization of AD, as a slowly progressive pathological process with a long asymptomatic phase. New concepts such
Maartje H. N. Schermer, Edo Richard
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IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2022 There are conventional screening instruments for the detection of cognitive impairment, but they have a reduced ecological validity and the information they present could be biased.
G. Palacios-Navarro +3 more
doaj +1 more source
Human microglial cells synthesize albumin in brain [PDF]
, 2008 Albumin has been implicated in Alzheimer's disease since it can bind to and transport amyloid beta, the causative agent; albumin is also a potent inhibitor of amyloid beta polymerization.
Bonghee Lee +9 more
core +5 more sources