Results 51 to 60 of about 1,659 (163)

Chemical evaluation and anticholinesterase activity of Hippeastrum puniceum (Lam.) Kuntz bulbs (Amaryllidaceae)

Brazilian Journal of Pharmaceutical Sciences, 2021
Hippeastrum puniceum is a species that belongs to the Amaryllidaceae family. A particular characteristic of this family is the consistent and very specific presence of isoquinoline alkaloids, which have demonstrated a wide range of biological activities ...
Letícia Carlesso Soprani, Jean P. de Andrade, Vanessa Dias dos Santos, Anderson Alves-Araújo, Jaume Bastida, Cristian A. Gasca Silva, Damaris Silveira, Warley de Souza Borges, Claudia Masrouah Jamal   +8 more
doaj   +1 more source

Escin Attenuates Amyloid Beta 1‐42‐Induced Oxidative Stress, Apoptosis, and Neuroinflammation in Neuron‐Like SH‐SY5Y Cells

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 5, May 2026.
This study demonstrates that Escin pretreatment exerts potent neuroprotection against Aβ1‐42‐induced toxicity in differentiated SH‐SY5Y cells. By suppressing the NF‐κB inflammatory axis, mitigating oxidative stress, and inhibiting the apoptotic cascade, Escin provides a mechanistic basis for its potential as a therapeutic candidate for Alzheimer's ...
Sakine Akar, Ozge Alvur, Gulsah Evyapan, Berna Ozdem, Ilknur Porsuk Doru   +4 more
wiley   +1 more source

Galantamine Quantity and Alkaloid Profile in the Bulbs of Narcissus tazetta and daffodil cultivars (Amaryllidaceae) Grown in Israel

Metabolites, 2021
Alkaloids produced by the bulbs of the Amaryllidaceae are a source of pharmaceutical compounds. The main alkaloid, galantamine, is a reversible acetylcholinesterase inhibitor and allosteric nicotinic receptor modulator, which slows cognitive and ...
Dana Atrahimovich, Raviv Harris, Ron Eitan, Menashe Cohen, Soliman Khatib   +4 more
doaj   +1 more source

AlkaPlorer: A database‐driven explorer for natural alkaloids and derivatives

Journal of Integrative Plant Biology, Volume 68, Issue 5, Page 1384-1398, May 2026.
The alkaloid database AlkaPlorer integrates over 130,000 compounds across 12,250 species. By linking chemical structures with biological and evolutionary data, it reveals how these molecules evolve and function. This platform serves as a vital resource for AI‐driven discovery in plant metabolism and modern drug development. ABSTRACT Alkaloids, renowned
Jiahao Li, Tao Zeng, Hongquan Xu, Xu Kang, Minghui Liang, Ruibo Wu   +5 more
wiley   +1 more source

Flavonoid Oxime Carbamate Derivatives: Reversal of Multidrug Resistance in Cancer Cells

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
A set of 23 new flavonoid oxime carbamates was synthesized and evaluated as multidrug resistance (MDR) reversers in ABCB1‐transfected mouse lymphoma cells. All derivatives strongly inhibited P‐glycoprotein (P‐gp) efflux activity in a transport assay, while most selected compounds behaved as ATPase inhibitors. In drug combination assays, they interacted
Filipa Barbosa, Gabriella Spengler, Noémi Bózsity, Nikoletta Szemerédi, István Zupkó, Maria‐José U. Ferreira   +5 more
wiley   +1 more source

Alternative Approaches and Plant‐Based Remedies for Livestock Health Management Among the Batswana of Southern Africa: A Review

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
ABSTRACT Due to limited access to, and the high cost of conventional veterinary services, Batswana communities often rely on ethnoveterinary practices for livestock health management. This review provides an in‐depth analysis on the ethnoveterinary uses, biological properties and safety assessment of plants utilised in livestock husbandry. A systematic
Tswelelopele G. Mpolokeng, Ndzalama Shikwambana, Mompati V. Chakale, John A. Asong, Lyndy J. McGaw, Stephen O. Amoo, Nqobile A. Masondo, Adeyemi O. Aremu   +7 more
wiley   +1 more source

Cytotoxic Agents of the Crinane Series of Amaryllidaceae Alkaloids

Natural Product Communications, 2013
In the alkaloid galanthamine, the plant family Amaryllidaceae has endowed the pharmaceutical community with a potent and selective inhibitor of the enzyme acetylcholinestersae (AChE), of prominence in the chemotherapeutic approach towards motor neuron ...
Jerald J. Nair, Jaume Bastida, Francesc Viladomat, Johannes van Staden   +3 more
doaj   +1 more source

Dual Targeting of DNA and EGFR by ZYH005 Induces DNA Damage and Mitotic Catastrophe in Glioblastoma

MedComm, Volume 7, Issue 4, April 2026.
ZYH005 exerts potent anti‐glioblastoma activity through a dual mechanism: intercalation‐mediated DNA damage and targeted inhibition of EGFR, leading to cell cycle arrest and mitotic catastrophe. ABSTRACT Glioblastoma multiforme (GBM) is an aggressive, therapy‐resistant brain tumor with limited treatment options.
Jianzheng Huang, Zijun Zhang, Yang Xiao, Ziming Zhao, Zengwei Luo, Junjun Liu, Suitian Lai, Chao Song, Shouchang Feng, Suojun Zhang, Xingjiang Yu, Qingyi Tong, Yonghui Zhang   +12 more
wiley   +1 more source

The Genus Nerine Herb. (Amaryllidaceae): Ethnobotany, Phytochemistry, and Biological Activity

Molecules, 2019
Nerine Herbert, family Amaryllidaceae, is a genus of about 30 species that are native to South Africa, Botswana, Lesotho, Namibia, and Swatini (formerly known as Swaziland). Species of Nerine are autumn-flowering, perennial, bulbous plants, which inhabit
Lucie Cahlíková, Nina Vaněčková, Marcela Šafratová, Kateřina Breiterová, Gerald Blunden, Daniela Hulcová, Lubomír Opletal   +6 more
doaj   +1 more source

Open data phylometabolomics reveals turnover‐dominated chemical divergence and clade‐specific physicochemical regimes across angiosperms

The Plant Journal, Volume 125, Issue 6, March 2026.
Significance Statement Using an open, reproducible phylometabolomics pipeline (LOTUS + standardized taxonomy; ~77 000 occurrences), we show that angiosperm chemodiversity diverges primarily by turnover (replacement), not nested accumulation. Despite this dynamism, major clades occupy distinct physicochemical regimes, revealing conserved constraints ...
Carlos Alexandre Carollo, Amanda Galdi Boaretto, Mariana Calarge Nocetti, Aline Regina Hellmann Carollo, Flávio Macedo Alves   +4 more
wiley   +1 more source