Results 61 to 70 of about 4,806 (212)

Dual Targeting of DNA and EGFR by ZYH005 Induces DNA Damage and Mitotic Catastrophe in Glioblastoma

MedComm, Volume 7, Issue 4, April 2026.
ZYH005 exerts potent anti‐glioblastoma activity through a dual mechanism: intercalation‐mediated DNA damage and targeted inhibition of EGFR, leading to cell cycle arrest and mitotic catastrophe. ABSTRACT Glioblastoma multiforme (GBM) is an aggressive, therapy‐resistant brain tumor with limited treatment options.
Jianzheng Huang, Zijun Zhang, Yang Xiao, Ziming Zhao, Zengwei Luo, Junjun Liu, Suitian Lai, Chao Song, Shouchang Feng, Suojun Zhang, Xingjiang Yu, Qingyi Tong, Yonghui Zhang   +12 more
wiley   +1 more source

The generalist inside the specialist: gut bacterial communities of two insect species feeding on toxic plants are dominated by enterococcus sp. [PDF]

, 2016
Some specialist insects feed on plants rich in secondary compounds, which pose a major selective pressure on both the phytophagous and the gut microbiota. However, microbial communities of toxic plant feeders are still poorly characterized. Here, we show
Baixeras, Joaquín, Latorre, Amparo, Porcar, Manuel, Vilanova, Cristina   +3 more
core   +1 more source

Magyarországon előforduló Amaryllidaceae és Ranunculaceae fajok növénykémiai elemzése: biológiailag aktív alkaloidok izolálása, szerkezetfelderítése és farmakológiai vizsgálata = Phytochemical investigation of Hungarian Amaryllidaceae and Ranunculaceae species: isolation, structure determination and pharmacological investigation of biologically active alkaloids [PDF]

, 2006
A kutatási program keretében az Amaryllidaceae családba tartozó Hymenocallis×festalis, Sprekelia formossissima, Leucojum vernum, Lycoris squamigera, és a Ranunculaceae családba tartozó Consolida orientalis, Aconitum vulparia, A. anthora és A.
Forgó, Péter, Hajdú, Zsuzsanna, Hohmann, Judit, Molnár, József, Rédei, Dóra   +4 more
core  

Up-regulation of p21 and TNF-alpha is mediated lycorine-induced death of HL-60 cells [PDF]

, 2010
Background Leukemia is one of the most life-threatening cancers today, and acute promyelogenous leukemia (APL) is a common type of leukemia. Many natural compounds have already been found to exhibit significant anti-tumor effects. Lycorine, a
Jing Liu, Ji-liang Hu, Bi-Wei Shi, Yang He, Wei-Xin Hu   +4 more
core   +2 more sources

Galanthus woronowii (amaryllidaceae)'nin antioksidan aktivitesi ve toplam fenolik içeriği [PDF]

, 2019
Plants have been used for medicinal purpose since ancient times. Due to the including bioactive secondary metabolites, plants have gained the great interest for drug discovery and development process.
Eminağaoğlu, Özgür, Erenler, Ramazan, Genç, Nusret   +2 more
core  

Alcaloides en la flora de Andalucia. III [PDF]

, 1989
Se han estudiado 79 especies vegetales características de la flora de Andalucía con objeto de determinar la presencia cualitativa y cuantitativa de alcaloides.
Cabezudo, Baltasar, García, Ana I., Nieto-Caldera, Jose Maria, Rico, Rodrigo, Salvo-Tierra, Angel Enrique, Suau, Rafael   +5 more
core   +7 more sources

Edible Seeds in the Fight Against Hypertension: A Review of In Vitro, In Vivo, and Clinical Evidences With a Mechanistic Insight of Bioactive Compounds

Food Frontiers, Volume 7, Issue 1, January 2026.
The presented review provides the potential antihypertensive benefits of traditionally employed edible seeds, presenting new perspectives and avenues for future research. ABSTRACT Hypertension, often referred to as a silent killer, is responsible for 7.5 million deaths, representing approximately 12.8% of all global mortality.
Jinmin Shi, Mohamad Fawzi Mahomoodally, Ahmed Abduljalal Abduljabbar, Ruttun Bushra Umme Zainab, Katharigatta N. Venugopala, Gokhan Zengin, Sakina Yagi, Meng‐Yao Li, Xuebo Hu   +8 more
wiley   +1 more source

Cytotoxic Activity of Amaryllidaceae Plants against Cancer Cells: Biotechnological, In Vitro, and In Silico Approaches

Molecules, 2023
Cancer is a major cause of death and an impediment to increasing life expectancy worldwide. With the aim of finding new molecules for chemotherapeutic treatment of epidemiological relevance, ten alkaloid fractions from Amaryllidaceae species were tested ...
Lina Trujillo, Janeth Bedoya, Natalie Cortés, Edison H. Osorio, Juan-Carlos Gallego, Hawer Leiva, Dagoberto Castro, Edison Osorio   +7 more
doaj   +1 more source

Natural Chiral Scaffolds in Alzheimer′s Disease: Therapeutic Potential, Mechanism, and Clinical Aspects

BioMed Research International, Volume 2026, Issue 1, 2026.
Alzheimer′s disease (AD) is a multifactorial neurodegenerative disorder characterized by progressive cognitive impairment, amyloid‐β deposition, tau pathology, oxidative stress, neuroinflammation, and dysfunction of synapses. Current therapeutic options are largely symptomatic and lack disease‐modifying efficacy.
Aniket Singh, Sanjeev Kumar Sahu, Anil Kumar Sah, Poorani Gurumallesh Prabu   +3 more
wiley   +1 more source

Cytotoxic Agents of the Crinane Series of Amaryllidaceae Alkaloids

Natural Product Communications, 2013
In the alkaloid galanthamine, the plant family Amaryllidaceae has endowed the pharmaceutical community with a potent and selective inhibitor of the enzyme acetylcholinestersae (AChE), of prominence in the chemotherapeutic approach towards motor neuron ...
Jerald J. Nair, Jaume Bastida, Francesc Viladomat, Johannes van Staden   +3 more
doaj   +1 more source