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The Use and Potential Benefits of N-Acetylcysteine in Non-Acetaminophen Acute Liver Failure: An Etiology-Based Review. [PDF]
BiomedicinesPopescu M +6 more
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Mushroom Poisoning and Acute Liver Injury: A Case-Based Review. [PDF]
CureusRoy S, Saleem H.
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Analytical methods for amatoxins: A comprehensive review
Journal of Pharmaceutical and Biomedical Analysis, 2023 Amatoxins are toxic bicyclic octapeptides found in certain wild mushroom species, particularly Amanita phalloides. These mushrooms contain predominantly α- and β-amanitin, which can lead to severe health risks for humans and animals if ingested.
Cátia Domingues +2 more
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Scandinavian Journal of Urology and Nephrology, 1990
Ingestion of mushrooms followed after 6-12 hours by gastrointestinal symptoms and after 3-4 days by hepatic symptoms is diagnostic for the life-threatening amatoxin intoxication and should be treated as soon as possible. Four case histories are reported and recommendations for treatment are given.
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Ingestion of mushrooms followed after 6-12 hours by gastrointestinal symptoms and after 3-4 days by hepatic symptoms is diagnostic for the life-threatening amatoxin intoxication and should be treated as soon as possible. Four case histories are reported and recommendations for treatment are given.
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Toxicokinetics of labeled amatoxins in the dog
Archives of Toxicology, 1985Radioactivities were measured in serum, urine, and bile of dogs at different times after intravenous injection of 14C-methyl-gamma-amanitin (14C-A) and 3H-O-methyl-dehydroxymethyl-alpha-amanitin (3H-A). For either substance, the relation between the specific plasma activity C and the time t could be best described with the function C = C1 X e- lambda 1
Faulstich, H., Talas, A., Wellhöner, H.
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Toxicon, 1987
A novel approach for the production of [125I]amatoxin and anti-amanitin is described. The antigen and the starting material for Bolton Hunter iodination is prepared by periodic acid oxidation of the gamma-delta-dihydroxy-isoleucine side chain of alpha-amanitin followed by reductive amination. The antigen seems to be of low apparent toxicity.
Andres, Roger Y., Frei, Werner
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A novel approach for the production of [125I]amatoxin and anti-amanitin is described. The antigen and the starting material for Bolton Hunter iodination is prepared by periodic acid oxidation of the gamma-delta-dihydroxy-isoleucine side chain of alpha-amanitin followed by reductive amination. The antigen seems to be of low apparent toxicity.
Andres, Roger Y., Frei, Werner
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Amatoxine und Knollenbl�tterpilzvergiftung
Naturwissenschaften, 1979Amatoxins are the sole cause of human Amanita poisoning, inhibition of transcription eventually leading to cell necrosis. The toxins are easily excreted into the bile fluid, a fact which postulates the interruption of the enterohepatic circulation. All therapeutic means should be applied in order to decrease the serum concentration of the toxins as ...
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Amatoxins in wood-rottingGalerina marginata
Mycologia, 2004Amatoxins, bicyclic octapeptide derivatives responsible for severe hepatic failure, are present in several Basidiomycota species belonging to four genera, i.e. Amanita, Conocybe, Galerina and Lepiota. DNA studies for G. autumnalis, G. marginata, G. oregonensis, G. unicolor and G.
Enjalbert, Françoise +4 more
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Mushrooms, amatoxins and the liver
Journal of Hepatology, 2005Acute liver failure (ALF) due to mushrooms containing amatoxins is relatively rare. In a survey of ALF in Spain, only 10 out of 267 cases (4%) were caused by amatoxins (pending publication). Amatoxin poisoning is a world wide problem: 50–100 fatal cases are reported yearly in Western Europe, being less common in the United States with fewer than 100 ...
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