Ambroxol attenuates detrimental effect of LPS-induced glia-mediated neuroinflammation, oxidative stress, and cognitive dysfunction in mice brain [PDF]
Frontiers in ImmunologyNeurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), are multifactorial. Among various factors, lipopolysaccharides (LPSs) from Gram-negative bacteria, such as E.
Safi Ullah +10 more
exaly +4 more sources
Efficacy and safety of inhaled ambroxol hydrochloride solution in patients with lower respiratory tract infectious diseases: a randomized, double-blind, placebo-controlled, multicentre clinical trial [PDF]
BMC Infectious DiseasesBackground Ambroxol is a widely used mucoactive agent, but the efficacy of inhaled ambroxol in patients with lower respiratory tract infectious (LRTI) disease is poorly understood.
Di Wu +8 more
doaj +2 more sources
Safety and Efficacy of Ambroxol Therapy in Polish Patients with Gaucher Disease [PDF]
LifeBackground: Gaucher disease (GD) is a lysosomal storage disorder caused by deficiency of β-glucocerebrosidase, leading to accumulation of glucocerebroside in lysosomes.
Patryk Lipiński +11 more
doaj +2 more sources
Unveiling the antibacterial action of ambroxol against Staphylococcus aureus bacteria: in vitro, in vivo, and in silico investigation [PDF]
BMC MicrobiologyIt is critical to find novel therapeutic approaches owing to the dissemination of multidrug resistance (MDR) in pathogenic bacteria, particularly Staphylococcus aureus. FDA-drug repurposing is an important therapeutic tactic to fight MDR bacteria.
Ahmed A. Abdelaziz +4 more
doaj +2 more sources
Efficacy of Ambroxol Combined with Loquat Syrup on Bacterial Pneumonia in Mice [PDF]
Journal of Inflammation ResearchChenping Li, Zhi Chen, Jiaqi Shi, Xiuyun Zheng Department of Pulmonary and Critical Care Medicine (PCCM), The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People’s Republic of ChinaCorrespondence: Xiuyun Zheng ...
Li C, Chen Z, Shi J, Zheng X
doaj +2 more sources
Ambroxol confers neuroprotection against scopolamine-induced Alzheimer’s-like pathology by modulating oxidative stress, neuroinflammation, and cognitive deficits via Nrf-2/JNK/GSK-3β signaling pathways [PDF]
Frontiers in Aging NeuroscienceAlzheimer’s disease (AD) is the most common and costly chronic progressive neurodegenerative disorder, with the highest impact on public health worldwide.
Waqas Ahmad +6 more
doaj +2 more sources
Efficacy and safety of inhaled ambroxol solution in improving sputum of lower respiratory tract infection in children: a multicenter, randomized, double-blind, placebo-controlled trial [PDF]
BMC Pulmonary MedicineObjective To evaluate the efficacy and safety of inhaled ambroxol solution in improving sputum of lower respiratory tract infections (LRTIs) in children.
Baoping Xu +9 more
doaj +2 more sources
Frontiers in Microbiology, 2022 Ambroxol is a commonly used mucolytic agent principally used to treat respiratory diseases, which may have a role as adjunctive therapy for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, but there is lack of evidence about its ...
Yun Lu +13 more
doaj +1 more source
Pharmaceutical Sciences and Research, 2023 Ambroxol HCl is a mucolytic agent often used to treat respiratory disorders associated with excess mucus secretion. This study aims to determine the beyond-use date (BUD) of ambroxol HCl syrup on the market based on analysis of the decrease in drug ...
Catur Jatmika +2 more
doaj +1 more source
Фармацевтичний журнал, 2020 The determination of the qualitative and quantitative content of the main active substance of a microlitic medicinal product is necessary to confirm its good quality.
І. V. Nigencovska +3 more
doaj +1 more source