Results 21 to 30 of about 5,969 (169)

In vitro and in vivo effects of Ambroxol chaperone therapy in two Italian patients affected by neuronopathic Gaucher disease and epilepsy

Molecular Genetics and Metabolism Reports, 2020
Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by mutations in the acid β-glucosidase encoding gene (GBA1), resulting in the deficient activity of acid β-glucosidase (GCase).
Giovanni Ciana, Andrea Dardis, Eleonora Pavan, Rosalia Maria Da Riol, Jessica Biasizzo, Dania Ferino, Manuela Zanatta, Antonella Boni, Luisa Antonini, Giovanni Crichiutti, Bruno Bembi   +10 more
doaj   +1 more source

An animal study on the effect of topically administered ambroxol for dry eye

Frontiers in Bioscience-Landmark, 2022
Objective: To evaluate the effect of 0.2% ambroxol eye drop on tear secretion and corneal healing on a rabbit dry eye model, and to delineate potential underlying mechanisms.
Zixuan Wang, Li Yu, Shaochong Zhang, Zhenhan Wang, Mingwu Wang   +4 more
doaj   +1 more source

Validasi Metode Analisis Klorfeniramin Maleat Dan Guaifenesin Menggunakan Kromatografi Cair Kinerja Tinggi Serta Aplikasinya Dalam Sediaan Sirup [PDF]

, 2017
The combination of CTM and GG is often used as an active substances to relieve symptoms of cough and cold. The concentration of CTM and GG in syrup are very low, so that it need validated determination method to ensure therapeutic dose. The purposes of
Afifah, I. (Ira), Budiarti, A. (Aqnes)
core   +5 more sources

Flow injection analysis using carbon film resistor electrodes for amperometric determination of ambroxol [PDF]

, 2008
Flow injection analysis (FIA) using a carbon film sensor for amperometric detection was explored for ambroxol analysis in pharmaceutical formulations.
Angnes, Lúcio, Brett, Christopher M. A., Felix, Fabiana S.   +2 more
core   +1 more source

Evaluation of safety and efficacy of inhaled ambroxol in hospitalized adult patients with mucopurulent sputum and expectoration difficulty

Frontiers in Medicine, 2023
BackgroundAmbroxol is a widely used mucoactive drug in sputum clearance of respiratory diseases taken orally and by injection. However, there is a paucity of evidence for inhaled ambroxol in sputum clearance.MethodsThis study performed a multicenter ...
Zeguang Zheng, Kai Yang, Ni Liu, Xiuhua Fu, Huijie He, Hong Chen, Peijun Xu, Jing Wang, Maofeng Liu, Yuling Tang, Fengzi Zhao, Shufeng Xu, Xiaowei Yu, Jichang Han, Bo Yuan, Bin Jia, Guifen Pang, Yantong Shi, Min Kuang, Haiyan Shao, Hao Xiong, Jia He, Yuanyuan Pan, Rongchang Chen   +23 more
doaj   +1 more source

Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells. [PDF]

, 2014
Gaucher disease is caused by mutations in the glucocerebrosidase gene, which encodes the lysosomal hydrolase glucosylceramidase. Patients with Gaucher disease and heterozygous glucocerebrosidase mutation carriers are at increased risk of developing ...
Abramov, AY, Chau, KY, Cooper, JM, Foltynie, T, Gegg, M, Hughes, D, Magalhaes, J, McNeill, A, Mehta, A, Schapira, AH, Shen, C   +10 more
core   +1 more source

Spectrophotometric Determination of Ambroxol by Chromotropic acid disodium salt dihydrate [PDF]

Journal of Bioscience and Applied Research
An easy and prompt spectrophotometric method was proposed for the limitation of the drug Ambroxol substance containing the amine group by the organic reagent (4,5-Dihydroxynaphthalene-2,7-disulfonic acid disodium salt dihydrate).
Riyadh R. Al - Araji, Abd Ali Abd Al-Hussein Shalan Al-Mushhdi   +1 more
doaj   +1 more source

Promising Effect of High Dose Ambroxol Treatment on Neurocognition and Motor Development in a Patient With Neuropathic Gaucher Disease 2

Frontiers in Neurology, 2022
Gaucher Disease (GD) 2 is a rare inherited lysosomal disorder. Early-onset and rapid progression of neurovisceral symptoms lead to fatal outcome in early childhood. Treatment is symptomatic, a curative therapy is currently not available. This prospective
Charlotte Aries, Benjamin Lohmöller, Stephan Tiede, Stephan Tiede, Karolin Täuber, Karolin Täuber, Guido Hartmann, Cornelia Rudolph, Nicole Muschol   +8 more
doaj   +1 more source

Conformationally-Locked C-Glycosides: Tuning Aglycone Interactions for Optimal Cheperone Behaviour in Gaucher Fibroblasts [PDF]

, 2016
A series of conformationally locked C-glycosides based on the 3-aminopyrano[3,2-b]pyrrol-2(1H)-one (APP) scaffold has been synthesized. The key step involved a totally stereocontrolled C-Michael addition of a serine-equivalent C-nucleophile to tri-O ...
Avenoza, A., Busto, J.H., Corzana, F., García Fernández, José Manuel, Higaki, Katsumi, Namba, E., Navo, C.D., Ortiz Mellet, Carmen, Peregrina, J.M., Sánchez Fernández, Elena Matilde   +9 more
core   +1 more source

Biological and antimicrobial properties of the association Ambroxol and a water-soluble viscous liquid as a vehicle for a tricalcium silicate-based sealer

Journal of Materials Science: Materials in Medicine, 2021
This study aimed to investigate the antimicrobial and biological properties of Ambroxol associated with glycerin (GLI), propylene glycol (PG), and polyethylene glycol (PEG) as a possible vehicle for an experimental tricalcium silicate sealer, with the ...
Índia Olinta de Azevedo Queiroz, Thiago Machado, Camila Carneiro Alves, Victor Gustavo Balera Brito, Bruno Carvalho de Vasconcelos, João Eduardo Gomes-Filho, Edilson Ervolino, Sandra Helena Penha de Oliveira, Marco Antonio Hungaro Duarte   +8 more
doaj   +1 more source